ENSG00000157212

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397192 ENSG00000157212 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXIP1 protein_coding protein_coding 13.03785 9.391622 14.55661 0.3515067 0.2068771 0.6316834 9.6202012 8.57894316 10.0338403 0.28484487 0.7724570 0.2257585 0.75148750 0.913766667 0.68830000 -0.22546667 1.195671e-05 1.195671e-05 FALSE TRUE
ENST00000457196 ENSG00000157212 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXIP1 protein_coding nonsense_mediated_decay 13.03785 9.391622 14.55661 0.3515067 0.2068771 0.6316834 0.8316647 0.41772495 1.2941438 0.04242850 0.1321034 1.6083477 0.06247500 0.044266667 0.08910000 0.04483333 4.124128e-02 1.195671e-05 FALSE TRUE
MSTRG.30964.6 ENSG00000157212 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXIP1 protein_coding   13.03785 9.391622 14.55661 0.3515067 0.2068771 0.6316834 0.9189305 0.00000000 0.8102649 0.00000000 0.8102649 6.3580180 0.06040417 0.000000000 0.05723333 0.05723333 9.090295e-01 1.195671e-05 FALSE TRUE
MSTRG.30964.7 ENSG00000157212 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXIP1 protein_coding   13.03785 9.391622 14.55661 0.3515067 0.2068771 0.6316834 0.5857810 0.04138066 1.3044876 0.04138066 0.4597900 4.6771314 0.04361250 0.004666667 0.08896667 0.08430000 7.261731e-03 1.195671e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157212 E001 0.9942340 0.0135649608 2.776510e-01 4.172528e-01 7 154943687 154943688 2 - 0.199 0.390 1.317
ENSG00000157212 E002 0.9942340 0.0135649608 2.776510e-01 4.172528e-01 7 154943689 154943689 1 - 0.199 0.390 1.317
ENSG00000157212 E003 1.1425272 0.0142481314 1.547792e-01 2.681205e-01 7 154943690 154943690 1 - 0.199 0.449 1.638
ENSG00000157212 E004 18.2708069 0.0203103120 1.657047e-06 1.311673e-05 7 154943691 154943783 93 - 0.962 1.479 1.838
ENSG00000157212 E005 49.8424551 0.0085585023 3.684902e-08 4.075983e-07 7 154943784 154943836 53 - 1.491 1.862 1.260
ENSG00000157212 E006 64.6358479 0.0004871204 2.885387e-18 1.499253e-16 7 154943837 154943889 53 - 1.587 1.978 1.323
ENSG00000157212 E007 158.9886379 0.0002768912 8.617124e-20 5.338418e-18 7 154943890 154944162 273 - 2.062 2.317 0.853
ENSG00000157212 E008 52.7726655 0.0074465720 1.121916e-03 4.376839e-03 7 154944163 154944164 2 - 1.615 1.816 0.680
ENSG00000157212 E009 2.6302196 0.0067417576 5.888270e-01 7.119931e-01 7 154946363 154946364 2 - 0.593 0.503 -0.418
ENSG00000157212 E010 106.9942783 0.0045312199 1.896435e-03 6.903404e-03 7 154946365 154946425 61 - 1.957 2.096 0.467
ENSG00000157212 E011 126.0374330 0.0014913162 6.137506e-04 2.583677e-03 7 154946512 154946587 76 - 2.041 2.160 0.396
ENSG00000157212 E012 171.6659040 0.0025045115 1.555019e-03 5.813851e-03 7 154946679 154946813 135 - 2.182 2.290 0.360
ENSG00000157212 E013 3.6038348 0.0160767415 1.992101e-04 9.604456e-04 7 154947832 154947902 71 - 0.870 0.237 -3.144
ENSG00000157212 E014 145.2211530 0.0002683224 2.117200e-01 3.405169e-01 7 154947903 154948003 101 - 2.149 2.182 0.111
ENSG00000157212 E015 172.5228983 0.0002464334 1.144840e-01 2.120911e-01 7 154954255 154954423 169 - 2.219 2.258 0.130
ENSG00000157212 E016 127.1512473 0.0002524890 9.817356e-01 9.926335e-01 7 154955529 154955631 103 - 2.110 2.106 -0.013
ENSG00000157212 E017 106.4404770 0.0012685764 3.524769e-01 4.967285e-01 7 154957224 154957294 71 - 2.052 2.014 -0.127
ENSG00000157212 E018 73.7308415 0.0003408838 7.074142e-01 8.053403e-01 7 154959890 154959933 44 - 1.884 1.865 -0.063
ENSG00000157212 E019 112.7180532 0.0009072355 9.996643e-01 1.000000e+00 7 154960893 154961048 156 - 2.061 2.058 -0.010
ENSG00000157212 E020 55.6179995 0.0066585240 5.475271e-01 6.775757e-01 7 154961049 154961077 29 - 1.739 1.774 0.118
ENSG00000157212 E021 72.0721339 0.0049037971 7.160453e-01 8.118094e-01 7 154961527 154961648 122 - 1.879 1.859 -0.065
ENSG00000157212 E022 99.3080391 0.0003616605 4.482975e-02 9.988899e-02 7 154962321 154962458 138 - 2.039 1.965 -0.250
ENSG00000157212 E023 0.1515154 0.0430889997 6.043286e-01   7 154962459 154962695 237 - 0.111 0.000 -8.006
ENSG00000157212 E024 82.3972031 0.0003296649 5.001891e-02 1.092087e-01 7 154963671 154963766 96 - 1.959 1.880 -0.267
ENSG00000157212 E025 5.0670231 0.0091562769 2.148940e-02 5.462367e-02 7 154963767 154965710 1944 - 0.919 0.591 -1.328
ENSG00000157212 E026 2.1433220 0.0068753207 2.311342e-01 3.638271e-01 7 154967320 154967815 496 - 0.593 0.390 -1.005
ENSG00000157212 E027 70.4977683 0.0004174013 1.315451e-01 2.362903e-01 7 154967816 154967910 95 - 1.889 1.822 -0.224
ENSG00000157212 E028 103.7465985 0.0002746519 4.380337e-01 5.799081e-01 7 154968403 154968832 430 - 2.009 2.033 0.078
ENSG00000157212 E029 61.6010335 0.0004175959 6.759104e-01 7.810259e-01 7 154968833 154968982 150 - 1.790 1.805 0.052
ENSG00000157212 E030 46.9431952 0.0005067817 9.590154e-01 9.783134e-01 7 154968983 154969048 66 - 1.686 1.680 -0.020
ENSG00000157212 E031 72.2337472 0.0003994454 6.380242e-01 7.517696e-01 7 154969049 154969126 78 - 1.877 1.854 -0.077
ENSG00000157212 E032 0.3332198 0.0295607415 8.676760e-01   7 154974154 154974623 470 - 0.111 0.135 0.318
ENSG00000157212 E033 178.9438864 0.0013339308 4.645285e-06 3.331196e-05 7 154975696 154976122 427 - 2.320 2.174 -0.488
ENSG00000157212 E034 132.2395761 0.0027543285 9.568515e-08 9.750559e-07 7 154976123 154976331 209 - 2.215 1.999 -0.724
ENSG00000157212 E035 98.3313254 0.0040811128 1.577014e-06 1.254295e-05 7 154983219 154983332 114 - 2.094 1.864 -0.774
ENSG00000157212 E036 0.6664265 0.0165357392 8.212237e-01 8.872982e-01 7 154983333 154983744 412 - 0.199 0.237 0.318
ENSG00000157212 E037 9.0444588 0.0018334463 1.062527e-05 7.018324e-05 7 154986017 154986179 163 - 1.184 0.666 -1.975
ENSG00000157212 E038 65.6412143 0.0067997455 3.966811e-06 2.888276e-05 7 154991006 154991069 64 - 1.938 1.658 -0.947
ENSG00000157212 E039 55.3659103 0.0195983739 1.170730e-02 3.283560e-02 7 154993726 154993769 44 - 1.843 1.633 -0.709
ENSG00000157212 E040 81.6714013 0.0038256347 3.728497e-05 2.165068e-04 7 154998650 154998784 135 - 2.007 1.800 -0.695
ENSG00000157212 E041 21.6957543 0.0008460277 1.564230e-08 1.859321e-07 7 155000080 155002100 2021 - 1.523 1.075 -1.570
ENSG00000157212 E042 39.8001848 0.0036849476 3.431975e-03 1.152919e-02 7 155002849 155003124 276 - 1.691 1.504 -0.638
ENSG00000157212 E043 2.1507855 0.0066656518 2.168123e-03 7.744488e-03 7 155003587 155003845 259 - 0.680 0.135 -3.382