ENSG00000157193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306052 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding protein_coding 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 1.6427862 0.9925976 2.3742309 0.05071304 0.12008313 1.2497812 0.19937917 0.14346667 0.25190000 0.108433333 3.867761e-03 1.51166e-10 FALSE TRUE
ENST00000354412 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding protein_coding 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.3971445 0.1678337 0.9026868 0.08491520 0.05684492 2.3595908 0.04531250 0.02363333 0.09573333 0.072100000 7.868833e-02 1.51166e-10 FALSE TRUE
ENST00000481431 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding nonsense_mediated_decay 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.5651945 0.3305730 1.0282088 0.33057301 0.30028600 1.6080606 0.06187500 0.04406667 0.10836667 0.064300000 2.611688e-01 1.51166e-10 FALSE FALSE
ENST00000653217 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding protein_coding 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.9608704 1.3493015 1.0605706 0.13843963 0.08592468 -0.3444856 0.13040417 0.19556667 0.11286667 -0.082700000 5.936356e-02 1.51166e-10 FALSE TRUE
ENST00000653810 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding nonsense_mediated_decay 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.7323947 0.8843174 1.2633909 0.16763941 0.15520150 0.5098166 0.09317500 0.12766667 0.13390000 0.006233333 9.491724e-01 1.51166e-10 TRUE TRUE
ENST00000658404 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding processed_transcript 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.4225255 0.1185837 0.7593403 0.11858369 0.22642750 2.5809143 0.05073333 0.01580000 0.08106667 0.065266667 1.555143e-01 1.51166e-10 FALSE TRUE
ENST00000668071 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding protein_coding 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.7455749 0.9056170 0.0000000 0.18125295 0.00000000 -6.5166724 0.09757917 0.13313333 0.00000000 -0.133133333 1.511660e-10 1.51166e-10 FALSE TRUE
ENST00000668991 ENSG00000157193 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP8 protein_coding processed_transcript 8.071339 6.932482 9.420862 0.2853355 0.1272113 0.4419382 0.7687343 0.1322058 0.4375103 0.13220581 0.22139759 1.6539404 0.08784167 0.01763333 0.04603333 0.028400000 6.576824e-01 1.51166e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157193 E001 165.2691388 0.0002955411 2.194882e-15 7.932349e-14 1 53242364 53245541 3178 - 2.319 2.100 -0.730
ENSG00000157193 E002 4.0875352 0.0240866769 8.210198e-02 1.628415e-01 1 53245542 53245544 3 - 0.822 0.544 -1.174
ENSG00000157193 E003 4.2358284 0.0246009059 1.347230e-01 2.407090e-01 1 53245545 53245545 1 - 0.822 0.586 -0.983
ENSG00000157193 E004 4.2358284 0.0246009059 1.347230e-01 2.407090e-01 1 53245546 53245546 1 - 0.822 0.586 -0.983
ENSG00000157193 E005 7.8281290 0.0545255932 5.142425e-01 6.489805e-01 1 53245547 53245551 5 - 0.997 0.874 -0.460
ENSG00000157193 E006 10.4474343 0.0212346211 8.129141e-01 8.813784e-01 1 53245552 53245579 28 - 1.045 1.069 0.085
ENSG00000157193 E007 9.9070610 0.0020158266 1.390157e-01 2.467360e-01 1 53245580 53245590 11 - 0.955 1.107 0.558
ENSG00000157193 E008 14.4383179 0.0095985664 7.463843e-01 8.341809e-01 1 53245591 53245623 33 - 1.175 1.204 0.103
ENSG00000157193 E009 97.3602293 0.0027818047 3.067412e-03 1.046539e-02 1 53245624 53245981 358 - 1.927 2.054 0.423
ENSG00000157193 E010 110.9159455 0.0003470559 3.681340e-07 3.344292e-06 1 53245982 53246551 570 - 1.957 2.125 0.565
ENSG00000157193 E011 3.9009015 0.0041371385 1.441567e-03 5.445023e-03 1 53246552 53246552 1 - 0.395 0.871 2.116
ENSG00000157193 E012 9.8062779 0.0017110782 1.216745e-06 9.922460e-06 1 53246553 53246557 5 - 0.686 1.223 2.027
ENSG00000157193 E013 10.0643565 0.0018941029 2.949316e-06 2.210202e-05 1 53246558 53246567 10 - 0.712 1.223 1.921
ENSG00000157193 E014 9.1860367 0.0021137873 1.054207e-05 6.971879e-05 1 53246568 53246578 11 - 0.686 1.184 1.890
ENSG00000157193 E015 10.2307369 0.0238608963 2.439683e-03 8.580857e-03 1 53246579 53246594 16 - 0.822 1.195 1.379
ENSG00000157193 E016 28.1040024 0.0007783713 2.232984e-01 3.543280e-01 1 53246595 53246709 115 - 1.418 1.497 0.269
ENSG00000157193 E017 57.6221881 0.0073625290 7.452947e-01 8.333806e-01 1 53246710 53246917 208 - 1.757 1.772 0.052
ENSG00000157193 E018 28.4337525 0.0111918277 5.667249e-01 6.936307e-01 1 53246918 53246923 6 - 1.443 1.484 0.140
ENSG00000157193 E019 31.5934680 0.0184815854 3.765045e-01 5.208222e-01 1 53246924 53246955 32 - 1.475 1.544 0.239
ENSG00000157193 E020 37.6766788 0.0160288552 4.136420e-01 5.570912e-01 1 53246956 53247017 62 - 1.553 1.612 0.200
ENSG00000157193 E021 36.4140681 0.0007308571 2.924098e-01 4.333852e-01 1 53247018 53247056 39 - 1.538 1.598 0.204
ENSG00000157193 E022 2.5766223 0.1132402755 3.770522e-01 5.213819e-01 1 53248463 53248591 129 - 0.629 0.448 -0.852
ENSG00000157193 E023 19.7553952 0.0009518320 9.723192e-01 9.867257e-01 1 53249380 53249440 61 - 1.313 1.315 0.006
ENSG00000157193 E024 17.0918953 0.0010537047 5.020941e-01 6.381894e-01 1 53249441 53249495 55 - 1.287 1.232 -0.194
ENSG00000157193 E025 16.3899838 0.0011776885 1.628490e-01 2.788548e-01 1 53249496 53249556 61 - 1.301 1.184 -0.410
ENSG00000157193 E026 45.7585002 0.0031070863 3.987370e-01 5.424781e-01 1 53250690 53250764 75 - 1.696 1.648 -0.161
ENSG00000157193 E027 45.0083583 0.0007552868 1.415682e-02 3.858164e-02 1 53250765 53250862 98 - 1.723 1.593 -0.441
ENSG00000157193 E028 13.9290633 0.0129936340 2.310825e-10 3.826404e-09 1 53251676 53252537 862 - 0.686 1.411 2.683
ENSG00000157193 E029 0.1482932 0.0414387407 4.091677e-01   1 53254911 53254957 47 - 0.000 0.132 9.243
ENSG00000157193 E030 24.6232895 0.0008588518 7.970432e-01 8.704977e-01 1 53255117 53255124 8 - 1.398 1.415 0.058
ENSG00000157193 E031 48.8198305 0.0069254800 2.694882e-01 4.079990e-01 1 53255125 53255185 61 - 1.663 1.735 0.243
ENSG00000157193 E032 0.7406253 0.0155001723 2.827261e-02 6.854834e-02 1 53255186 53257239 2054 - 0.395 0.000 -11.642
ENSG00000157193 E033 75.0457351 0.0003947070 1.055715e-02 3.010719e-02 1 53257240 53257464 225 - 1.827 1.929 0.344
ENSG00000157193 E034 1.9823408 0.0103916140 7.485079e-01 8.357373e-01 1 53258009 53258074 66 - 0.444 0.498 0.270
ENSG00000157193 E035 76.3785711 0.0003523815 5.254683e-02 1.136955e-01 1 53258319 53258465 147 - 1.849 1.925 0.256
ENSG00000157193 E036 33.8653114 0.0049234369 3.230273e-01 4.663710e-01 1 53258466 53258471 6 - 1.511 1.577 0.225
ENSG00000157193 E037 78.0642981 0.0016928794 4.530064e-01 5.938070e-01 1 53260464 53260605 142 - 1.884 1.916 0.105
ENSG00000157193 E038 1.7241735 0.0777789589 1.181726e-01 2.173158e-01 1 53261213 53261787 575 - 0.276 0.581 1.661
ENSG00000157193 E039 64.4165216 0.0020422825 9.353993e-01 9.633363e-01 1 53262068 53262207 140 - 1.821 1.816 -0.016
ENSG00000157193 E040 44.4543654 0.0004778755 3.346369e-01 4.783842e-01 1 53262446 53262564 119 - 1.683 1.631 -0.174
ENSG00000157193 E041 30.4836647 0.0041571001 1.826227e-01 3.044883e-01 1 53264169 53264215 47 - 1.541 1.449 -0.316
ENSG00000157193 E042 66.1637585 0.0036277889 3.377374e-01 4.816369e-01 1 53264216 53264396 181 - 1.849 1.799 -0.169
ENSG00000157193 E043 61.8840100 0.0253068727 2.235576e-01 3.546382e-01 1 53266473 53266647 175 - 1.847 1.742 -0.355
ENSG00000157193 E044 2.0109208 0.1228662912 8.816780e-01 9.281834e-01 1 53266648 53266699 52 - 0.489 0.448 -0.206
ENSG00000157193 E045 1.2649996 0.0109474455 6.592706e-01 7.681232e-01 1 53266700 53268598 1899 - 0.395 0.316 -0.469
ENSG00000157193 E046 37.4616567 0.0212022778 1.381677e-02 3.781147e-02 1 53271028 53271153 126 - 1.682 1.457 -0.767
ENSG00000157193 E047 39.4573447 0.0018960697 7.034409e-02 1.439284e-01 1 53271227 53271346 120 - 1.655 1.548 -0.364
ENSG00000157193 E048 1.6919979 0.0079906413 2.243967e-01 3.556884e-01 1 53271347 53271415 69 - 0.528 0.316 -1.147
ENSG00000157193 E049 9.4108917 0.0018271418 5.550096e-01 6.839093e-01 1 53271416 53272603 1188 - 1.045 0.981 -0.234
ENSG00000157193 E050 10.4502033 0.0037688105 9.910753e-01 9.985387e-01 1 53272604 53272642 39 - 1.056 1.056 -0.002
ENSG00000157193 E051 11.0410147 0.0202431870 1.739548e-01 2.933236e-01 1 53272643 53275630 2988 - 1.156 0.996 -0.581
ENSG00000157193 E052 18.3113742 0.0044960709 7.063183e-01 8.044712e-01 1 53275631 53275654 24 - 1.301 1.268 -0.115
ENSG00000157193 E053 27.6760715 0.0008822335 2.654311e-01 4.034914e-01 1 53275655 53275753 99 - 1.495 1.421 -0.254
ENSG00000157193 E054 10.5764609 0.0606580034 8.112780e-01 8.802443e-01 1 53276692 53277078 387 - 1.090 1.030 -0.218
ENSG00000157193 E055 30.5776480 0.0016271912 1.795207e-01 3.005396e-01 1 53280587 53280715 129 - 1.538 1.450 -0.303
ENSG00000157193 E056 0.3729606 0.0304077554 8.877118e-01 9.322251e-01 1 53289332 53289566 235 - 0.113 0.133 0.271
ENSG00000157193 E057 33.4573423 0.0006526912 5.922254e-02 1.253061e-01 1 53289567 53289689 123 - 1.591 1.476 -0.392
ENSG00000157193 E058 0.0000000       1 53291789 53291790 2 -      
ENSG00000157193 E059 0.5149111 0.0204542460 4.632844e-01 6.030947e-01 1 53291791 53291917 127 - 0.113 0.234 1.269
ENSG00000157193 E060 0.6966155 0.0172671820 2.329001e-01 3.658684e-01 1 53291918 53292028 111 - 0.113 0.316 1.854
ENSG00000157193 E061 1.7587160 0.0088947106 2.612188e-02 6.418978e-02 1 53292029 53292292 264 - 0.202 0.587 2.270
ENSG00000157193 E062 0.0000000       1 53295799 53296104 306 -      
ENSG00000157193 E063 0.0000000       1 53312969 53313143 175 -      
ENSG00000157193 E064 0.2934659 0.0295580135 8.938366e-01   1 53313573 53313743 171 - 0.113 0.132 0.266
ENSG00000157193 E065 24.9423888 0.0010599101 9.081222e-02 1.764150e-01 1 53326873 53326992 120 - 1.469 1.351 -0.409
ENSG00000157193 E066 0.6558305 0.0931979316 8.629753e-01 9.156411e-01 1 53327258 53327463 206 - 0.202 0.235 0.273
ENSG00000157193 E067 14.0858878 0.0013065997 1.598072e-02 4.268714e-02 1 53327789 53328469 681 - 1.274 1.055 -0.780