ENSG00000157077

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287727 ENSG00000157077 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE9 protein_coding protein_coding 6.605004 2.881119 9.554395 0.2621724 0.147351 1.726046 4.5105789 1.8110668 7.8920077 0.28802195 0.09084560 2.1174354 0.6510333 0.62130000 0.82643333 0.20513333 0.001324669 0.001324669 FALSE TRUE
ENST00000357206 ENSG00000157077 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE9 protein_coding protein_coding 6.605004 2.881119 9.554395 0.2621724 0.147351 1.726046 1.4094207 0.7309958 1.2618914 0.10756013 0.21453433 0.7794382 0.2157250 0.25526667 0.13153333 -0.12373333 0.075995572 0.001324669 FALSE TRUE
ENST00000371591 ENSG00000157077 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE9 protein_coding protein_coding 6.605004 2.881119 9.554395 0.2621724 0.147351 1.726046 0.3512254 0.2196592 0.3492579 0.03385094 0.02426237 0.6455252 0.0667875 0.07946667 0.03663333 -0.04283333 0.136703459 0.001324669 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157077 E001 7.7019271 0.0190689893 3.044090e-02 7.282773e-02 1 52142089 52142211 123 + 0.997 0.667 -1.293
ENSG00000157077 E002 19.5613973 0.0030188656 1.424887e-04 7.143362e-04 1 52142212 52142373 162 + 1.376 0.994 -1.360
ENSG00000157077 E003 14.6264315 0.0011907040 3.110401e-03 1.059153e-02 1 52142374 52142403 30 + 1.242 0.919 -1.172
ENSG00000157077 E004 0.5891098 0.0183539646 2.318334e-01 3.646338e-01 1 52199251 52199431 181 + 0.258 0.000 -10.628
ENSG00000157077 E005 26.0991228 0.0010164248 2.740426e-05 1.645384e-04 1 52216369 52216474 106 + 1.489 1.131 -1.254
ENSG00000157077 E006 29.1830110 0.0006699694 1.094001e-04 5.652839e-04 1 52233171 52233276 106 + 1.528 1.221 -1.064
ENSG00000157077 E007 310.1386947 0.0030161224 1.335754e-09 1.933781e-08 1 52237488 52239595 2108 + 2.516 2.324 -0.641
ENSG00000157077 E008 35.9397979 0.0029707734 5.446406e-01 6.750841e-01 1 52263773 52263872 100 + 1.553 1.502 -0.174
ENSG00000157077 E009 0.0000000       1 52263873 52264047 175 +      
ENSG00000157077 E010 49.0708880 0.0004384122 1.537553e-01 2.667712e-01 1 52266655 52266831 177 + 1.697 1.609 -0.299
ENSG00000157077 E011 41.6519571 0.0006108941 6.823153e-01 7.857764e-01 1 52268463 52268570 108 + 1.600 1.614 0.049
ENSG00000157077 E012 33.1673632 0.0005967464 8.166225e-01 8.839775e-01 1 52268571 52268632 62 + 1.503 1.509 0.019
ENSG00000157077 E013 41.7091373 0.0005603419 6.496497e-01 7.608585e-01 1 52274464 52274584 121 + 1.598 1.614 0.057
ENSG00000157077 E014 44.2671989 0.0005389010 7.971130e-01 8.705290e-01 1 52278492 52278614 123 + 1.626 1.631 0.017
ENSG00000157077 E015 60.7693905 0.0004269950 5.728511e-01 6.988982e-01 1 52281661 52281816 156 + 1.756 1.774 0.059
ENSG00000157077 E016 86.1202424 0.0027752063 5.388393e-01 6.702157e-01 1 52293453 52293677 225 + 1.904 1.922 0.059
ENSG00000157077 E017 49.9378827 0.0004597993 1.626383e-01 2.785911e-01 1 52295895 52295977 83 + 1.658 1.721 0.215
ENSG00000157077 E018 52.8350268 0.0004380006 6.423860e-01 7.551758e-01 1 52303821 52303925 105 + 1.714 1.681 -0.114
ENSG00000157077 E019 66.8976601 0.0003799780 1.987494e-02 5.122438e-02 1 52332768 52332918 151 + 1.771 1.866 0.319
ENSG00000157077 E020 55.4330555 0.0004654594 3.295140e-02 7.770834e-02 1 52334688 52334768 81 + 1.690 1.785 0.323
ENSG00000157077 E021 0.2924217 0.0273893669 6.277524e-01   1 52334769 52335207 439 + 0.148 0.000 -9.606
ENSG00000157077 E022 75.9184015 0.0003977548 2.454028e-02 6.093321e-02 1 52337772 52337934 163 + 1.825 1.910 0.288
ENSG00000157077 E023 58.6697162 0.0010343541 7.697341e-05 4.137316e-04 1 52340126 52340231 106 + 1.679 1.860 0.613
ENSG00000157077 E024 79.4386067 0.0065516431 5.592440e-03 1.753423e-02 1 52344768 52344944 177 + 1.828 1.968 0.472
ENSG00000157077 E025 101.4676874 0.0048063154 2.450976e-05 1.489957e-04 1 52346060 52346634 575 + 1.914 2.102 0.629
ENSG00000157077 E026 3.1512725 0.0175037452 1.170735e-01 2.157700e-01 1 52346635 52346848 214 + 0.510 0.754 1.065
ENSG00000157077 E027 16.8126841 0.0012823772 7.214078e-04 2.975324e-03 1 52346849 52348671 1823 + 1.113 1.389 0.970
ENSG00000157077 E028 1.3242316 0.0108260031 6.053821e-03 1.875179e-02 1 52349938 52349962 25 + 0.148 0.616 2.944