ENSG00000157036

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287675 ENSG00000157036 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOG protein_coding protein_coding 13.66013 10.11712 17.95324 1.758257 0.5344981 0.8268242 7.180686 6.5554716 8.028979 1.471561 0.4339356 0.2921136 0.54574167 0.63770000 0.4466000 -0.19110000 0.022372422 0.002098352 FALSE TRUE
ENST00000483749 ENSG00000157036 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOG protein_coding retained_intron 13.66013 10.11712 17.95324 1.758257 0.5344981 0.8268242 1.772835 0.4463990 3.101242 0.162151 0.4934654 2.7691229 0.11656250 0.04243333 0.1746000 0.13216667 0.002098352 0.002098352 FALSE TRUE
ENST00000489813 ENSG00000157036 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOG protein_coding retained_intron 13.66013 10.11712 17.95324 1.758257 0.5344981 0.8268242 1.080246 0.2944434 2.183354 0.147232 0.2086490 2.8488924 0.07072083 0.02956667 0.1216333 0.09206667 0.126792335 0.002098352 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157036 E001 0.0000000       3 38495974 38496126 153 +      
ENSG00000157036 E002 0.0000000       3 38496127 38496271 145 +      
ENSG00000157036 E003 0.1817044 0.0441546029 3.802614e-01   3 38496272 38496339 68 + 0.000 0.138 10.181
ENSG00000157036 E004 0.1817044 0.0441546029 3.802614e-01   3 38496340 38496341 2 + 0.000 0.138 12.322
ENSG00000157036 E005 0.1817044 0.0441546029 3.802614e-01   3 38496342 38496342 1 + 0.000 0.138 12.322
ENSG00000157036 E006 0.3289534 0.0274700790 8.631332e-01   3 38496343 38496344 2 + 0.108 0.138 0.409
ENSG00000157036 E007 14.6711412 0.0333724631 8.926073e-01 9.353902e-01 3 38496345 38496364 20 + 1.203 1.192 -0.038
ENSG00000157036 E008 39.3741728 0.0008788452 7.036833e-01 8.023586e-01 3 38496365 38496480 116 + 1.617 1.617 0.002
ENSG00000157036 E009 30.1813438 0.0007008226 4.371349e-01 5.791511e-01 3 38496481 38496484 4 + 1.517 1.491 -0.091
ENSG00000157036 E010 31.4108704 0.0009288455 2.975080e-01 4.388573e-01 3 38496485 38496491 7 + 1.543 1.501 -0.143
ENSG00000157036 E011 49.1936948 0.0004950526 3.397485e-01 4.836768e-01 3 38496492 38496530 39 + 1.724 1.699 -0.083
ENSG00000157036 E012 3.8835815 0.0070963911 1.345378e-02 3.697311e-02 3 38496738 38496842 105 + 0.823 0.459 -1.591
ENSG00000157036 E013 5.8065886 0.0030075151 3.409485e-02 7.994316e-02 3 38496843 38496929 87 + 0.936 0.677 -1.024
ENSG00000157036 E014 11.8123174 0.0043043490 5.185430e-11 9.608413e-10 3 38496930 38497628 699 + 1.323 0.559 -2.933
ENSG00000157036 E015 61.0886408 0.0020463060 1.129389e-01 2.098299e-01 3 38497629 38497684 56 + 1.828 1.772 -0.189
ENSG00000157036 E016 34.7129320 0.0116209844 2.216765e-02 5.602298e-02 3 38497685 38497689 5 + 1.631 1.465 -0.567
ENSG00000157036 E017 61.9617200 0.0005052335 2.798358e-03 9.669864e-03 3 38497690 38497778 89 + 1.855 1.743 -0.378
ENSG00000157036 E018 8.3958884 0.0020473889 1.433689e-05 9.185255e-05 3 38497779 38498022 244 + 1.146 0.641 -1.945
ENSG00000157036 E019 5.8106300 0.0303054631 4.057675e-03 1.330347e-02 3 38498767 38498836 70 + 0.990 0.559 -1.742
ENSG00000157036 E020 10.3554106 0.0483346000 5.806415e-02 1.233165e-01 3 38498926 38498989 64 + 1.170 0.888 -1.037
ENSG00000157036 E021 12.2776651 0.0014524657 4.984625e-03 1.588752e-02 3 38499681 38499747 67 + 1.233 0.983 -0.901
ENSG00000157036 E022 18.1252555 0.0010563529 6.946877e-05 3.774637e-04 3 38500090 38500164 75 + 1.408 1.101 -1.081
ENSG00000157036 E023 10.0355146 0.0523565638 7.843662e-04 3.203739e-03 3 38501162 38501354 193 + 1.220 0.706 -1.933
ENSG00000157036 E024 71.0578100 0.0004348055 3.804954e-02 8.744416e-02 3 38501355 38501415 61 + 1.891 1.826 -0.220
ENSG00000157036 E025 77.4391043 0.0069592346 7.548185e-01 8.403447e-01 3 38501416 38501494 79 + 1.885 1.908 0.077
ENSG00000157036 E026 0.2924217 0.0290785164 2.886302e-01   3 38501495 38501502 8 + 0.194 0.000 -13.873
ENSG00000157036 E027 70.9959193 0.0029535354 5.426908e-01 6.733987e-01 3 38503615 38503691 77 + 1.839 1.885 0.154
ENSG00000157036 E028 54.2971503 0.0008282385 7.401024e-01 8.296045e-01 3 38506854 38506886 33 + 1.744 1.749 0.015
ENSG00000157036 E029 84.0444211 0.0032507389 9.530286e-02 1.833335e-01 3 38506887 38506968 82 + 1.888 1.982 0.314
ENSG00000157036 E030 0.0000000       3 38513750 38513772 23 +      
ENSG00000157036 E031 0.1515154 0.0446469522 6.365815e-01   3 38513773 38513868 96 + 0.108 0.000 -12.723
ENSG00000157036 E032 2.5369952 0.0067528710 3.006895e-01 4.424242e-01 3 38519262 38519377 116 + 0.613 0.459 -0.728
ENSG00000157036 E033 2.0293693 0.0071647469 8.951670e-01 9.369949e-01 3 38523173 38523216 44 + 0.474 0.512 0.185
ENSG00000157036 E034 67.6807724 0.0004218579 2.673703e-01 4.056842e-01 3 38523901 38523945 45 + 1.812 1.880 0.231
ENSG00000157036 E035 225.4987862 0.0002007284 6.869303e-02 1.411999e-01 3 38523946 38524403 458 + 2.334 2.396 0.207
ENSG00000157036 E036 112.6438193 0.0041569224 4.832570e-02 1.062034e-01 3 38524404 38524598 195 + 2.012 2.112 0.333
ENSG00000157036 E037 396.0179260 0.0047629465 5.602868e-03 1.756053e-02 3 38524599 38526303 1705 + 2.551 2.654 0.343
ENSG00000157036 E038 2.8721725 0.1688935672 5.084117e-02 1.106724e-01 3 38541767 38542161 395 + 0.328 0.749 2.030