ENSG00000156983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000383829 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 1.4832662 1.416536 4.41605124 1.1299135 1.78466737 1.6335039 0.05907917 0.03960000 0.176600000 0.13700000 2.932326e-01 1.651145e-09 FALSE TRUE
ENST00000433861 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 1.2631192 0.000000 1.93545246 0.0000000 1.93545246 7.6039619 0.04728750 0.00000000 0.078566667 0.07856667 8.231715e-01 1.651145e-09 FALSE TRUE
ENST00000672515 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 1.9763728 2.211435 1.29380941 2.2114346 1.29380941 -0.7687587 0.06623750 0.06283333 0.052500000 -0.01033333 1.000000e+00 1.651145e-09 FALSE TRUE
ENST00000682208 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 2.1390947 4.019190 2.28253194 2.0520515 1.35524914 -0.8135481 0.08163333 0.11763333 0.091300000 -0.02633333 9.792785e-01 1.651145e-09 FALSE TRUE
ENST00000682980 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 2.7531130 4.944215 1.26485764 0.6482636 1.26485764 -1.9583203 0.10037500 0.14380000 0.052433333 -0.09136667 1.431437e-01 1.651145e-09 FALSE TRUE
ENST00000683743 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 5.5620672 10.436361 1.75840022 0.6490035 1.75840022 -2.5624838 0.19056250 0.30093333 0.072900000 -0.22803333 8.807384e-02 1.651145e-09 FALSE TRUE
ENST00000684206 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 0.6227195 0.000000 1.60198216 0.0000000 1.60198216 7.3326920 0.02471667 0.00000000 0.062966667 0.06296667 8.181495e-01 1.651145e-09 FALSE TRUE
ENST00000684333 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 5.6126134 3.651149 6.36425864 2.0051576 1.57419365 0.7999612 0.21263750 0.10253333 0.258700000 0.15616667 6.152024e-01 1.651145e-09 FALSE TRUE
ENST00000684573 ENSG00000156983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF1 protein_coding protein_coding 27.27459 34.66395 24.73108 0.8871051 0.3842677 -0.4869437 1.3326750 5.193704 0.02571461 1.3851048 0.02571461 -7.1868808 0.03989583 0.15213333 0.001033333 -0.15110000 1.651145e-09 1.651145e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156983 E001 0.767592 0.0157192302 3.645011e-01 5.088479e-01 3 9731729 9731734 6 + 0.344 0.184 -1.197
ENSG00000156983 E002 1.586566 0.0085613186 5.538163e-02 1.186449e-01 3 9731735 9731744 10 + 0.582 0.253 -1.834
ENSG00000156983 E003 1.404862 0.0095712643 2.132179e-02 5.426535e-02 3 9731745 9731745 1 + 0.582 0.184 -2.419
ENSG00000156983 E004 2.282137 0.0066694092 6.700809e-02 1.383957e-01 3 9731746 9731747 2 + 0.665 0.365 -1.458
ENSG00000156983 E005 6.529967 0.0025349685 7.366335e-02 1.493904e-01 3 9731748 9731753 6 + 0.993 0.778 -0.824
ENSG00000156983 E006 30.717034 0.0230148228 3.145497e-01 4.572628e-01 3 9731754 9731787 34 + 1.531 1.444 -0.299
ENSG00000156983 E007 82.480257 0.0428498222 1.943411e-01 3.192070e-01 3 9731788 9731847 60 + 1.967 1.858 -0.366
ENSG00000156983 E008 167.823868 0.0203691394 4.507278e-02 1.003278e-01 3 9731848 9732128 281 + 2.287 2.155 -0.441
ENSG00000156983 E009 61.044863 0.0032129583 2.473296e-03 8.683281e-03 3 9732129 9732138 10 + 1.866 1.707 -0.536
ENSG00000156983 E010 1.468462 0.0098925482 1.068553e-01 2.009052e-01 3 9732224 9732479 256 + 0.533 0.253 -1.610
ENSG00000156983 E011 2.463856 0.0062654246 2.043644e-02 5.240845e-02 3 9732480 9732662 183 + 0.734 0.365 -1.750
ENSG00000156983 E012 1.508215 0.0129941938 7.740065e-01 8.542670e-01 3 9732663 9732687 25 + 0.416 0.365 -0.289
ENSG00000156983 E013 4.623521 0.0165934667 5.615062e-02 1.199694e-01 3 9732688 9733172 485 + 0.894 0.619 -1.113
ENSG00000156983 E014 3.444374 0.1184564878 8.559805e-02 1.683585e-01 3 9733173 9733370 198 + 0.821 0.491 -1.422
ENSG00000156983 E015 425.534374 0.0038726364 8.644975e-09 1.078186e-07 3 9734131 9734739 609 + 2.722 2.534 -0.625
ENSG00000156983 E016 792.008454 0.0003247713 8.791218e-19 4.894123e-17 3 9738999 9739958 960 + 2.953 2.829 -0.413
ENSG00000156983 E017 260.299338 0.0003676662 3.255185e-01 4.689477e-01 3 9740779 9740941 163 + 2.408 2.384 -0.080
ENSG00000156983 E018 231.435498 0.0001975317 7.716671e-01 8.526096e-01 3 9741308 9741439 132 + 2.338 2.344 0.021
ENSG00000156983 E019 1.109319 0.0113666067 1.266873e-02 3.513063e-02 3 9742008 9742024 17 + 0.533 0.102 -3.195
ENSG00000156983 E020 230.245993 0.0003031417 6.560701e-01 7.658025e-01 3 9742025 9742153 129 + 2.334 2.344 0.035
ENSG00000156983 E021 46.819105 0.0108203359 5.526399e-01 6.819074e-01 3 9742154 9742171 18 + 1.678 1.638 -0.136
ENSG00000156983 E022 8.170205 0.0026030969 2.201371e-02 5.570603e-02 3 9742172 9742320 149 + 1.089 0.832 -0.959
ENSG00000156983 E023 3.034416 0.0050878882 1.249423e-02 3.472007e-02 3 9742321 9742351 31 + 0.794 0.412 -1.727
ENSG00000156983 E024 14.923201 0.0011978081 5.040898e-03 1.604205e-02 3 9742352 9742541 190 + 1.325 1.081 -0.863
ENSG00000156983 E025 12.308374 0.0464785225 1.064487e-02 3.031902e-02 3 9742542 9742943 402 + 1.290 0.943 -1.254
ENSG00000156983 E026 254.064010 0.0002005582 2.060882e-01 3.337933e-01 3 9742944 9743077 134 + 2.403 2.373 -0.100
ENSG00000156983 E027 302.817042 0.0001593242 8.884317e-01 9.326709e-01 3 9743078 9743253 176 + 2.458 2.461 0.008
ENSG00000156983 E028 6.224013 0.0032098449 8.078958e-01 8.779368e-01 3 9743254 9743471 218 + 0.847 0.815 -0.124
ENSG00000156983 E029 52.898306 0.0032096565 2.373174e-01 3.710657e-01 3 9743578 9743580 3 + 1.663 1.731 0.230
ENSG00000156983 E030 387.272979 0.0002246908 2.526256e-02 6.241170e-02 3 9743581 9743901 321 + 2.539 2.582 0.142
ENSG00000156983 E031 279.590827 0.0018324289 1.859082e-01 3.086392e-01 3 9744224 9744508 285 + 2.398 2.439 0.136
ENSG00000156983 E032 3.161413 0.0050692786 8.081249e-01 8.780804e-01 3 9744509 9744541 33 + 0.582 0.619 0.166
ENSG00000156983 E033 261.555985 0.0001686039 2.180563e-01 3.480769e-01 3 9745008 9745155 148 + 2.377 2.405 0.092
ENSG00000156983 E034 5.687220 0.0030459178 2.285577e-01 3.607034e-01 3 9745200 9745572 373 + 0.894 0.739 -0.611
ENSG00000156983 E035 276.604882 0.0002917951 2.487470e-05 1.509622e-04 3 9745573 9745709 137 + 2.355 2.453 0.325
ENSG00000156983 E036 47.198392 0.0050142733 8.449514e-03 2.490951e-02 3 9745710 9745811 102 + 1.546 1.715 0.573
ENSG00000156983 E037 301.514816 0.0004077091 6.241183e-07 5.417022e-06 3 9745812 9745930 119 + 2.381 2.496 0.381
ENSG00000156983 E038 6.005403 0.0095991823 3.502350e-01 4.944311e-01 3 9745931 9746299 369 + 0.916 0.796 -0.465
ENSG00000156983 E039 353.225031 0.0015790675 2.901784e-04 1.339966e-03 3 9746300 9746454 155 + 2.463 2.561 0.328
ENSG00000156983 E040 144.897375 0.0002624013 2.714416e-03 9.416381e-03 3 9747166 9747169 4 + 2.081 2.174 0.311
ENSG00000156983 E041 792.806114 0.0032713296 1.649152e-08 1.952912e-07 3 9747170 9748019 850 + 2.769 2.930 0.534