ENSG00000156869

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287474 ENSG00000156869 HEK293_OSMI2_2hA HEK293_TMG_2hB FRRS1 protein_coding protein_coding 2.586991 0.7339717 3.207397 0.2536364 0.1268929 2.112574 1.3152045 0.0000000 1.6939013 0.0000000 0.11819195 7.4126980 0.3198292 0 0.5278667 0.5278667 2.750892e-12 1.728323e-15 FALSE TRUE
ENST00000492943 ENSG00000156869 HEK293_OSMI2_2hA HEK293_TMG_2hB FRRS1 protein_coding processed_transcript 2.586991 0.7339717 3.207397 0.2536364 0.1268929 2.112574 0.1323068 0.0000000 0.3962134 0.0000000 0.13861739 5.3441659 0.0493875 0 0.1218667 0.1218667 2.479683e-02 1.728323e-15   FALSE
ENST00000646001 ENSG00000156869 HEK293_OSMI2_2hA HEK293_TMG_2hB FRRS1 protein_coding protein_coding 2.586991 0.7339717 3.207397 0.2536364 0.1268929 2.112574 1.1394797 0.7339717 1.1172823 0.2536364 0.03919081 0.5995292 0.6307833 1 0.3502667 -0.6497333 1.728323e-15 1.728323e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156869 E001 96.1878723 0.0005841327 6.026283e-47 3.119293e-44 1 99703970 99708702 4733 - 1.773 2.232 1.539
ENSG00000156869 E002 32.5763197 0.0007002737 7.216175e-01 8.159176e-01 1 99708703 99709120 418 - 1.506 1.490 -0.058
ENSG00000156869 E003 14.5610654 0.0174416400 6.700505e-01 7.766326e-01 1 99709198 99709259 62 - 1.180 1.131 -0.175
ENSG00000156869 E004 10.2605157 0.0018498758 6.761775e-01 7.812282e-01 1 99710806 99710824 19 - 1.037 0.996 -0.151
ENSG00000156869 E005 9.1772100 0.0018705599 1.503246e-01 2.621151e-01 1 99710825 99710833 9 - 1.029 0.863 -0.624
ENSG00000156869 E006 15.2563126 0.0012510403 1.606637e-01 2.759872e-01 1 99710834 99710918 85 - 1.224 1.098 -0.450
ENSG00000156869 E007 10.0284482 0.0018352840 5.262277e-01 6.594755e-01 1 99710919 99710949 31 - 1.037 0.973 -0.238
ENSG00000156869 E008 0.8815316 0.0140848078 1.103555e-01 2.060658e-01 1 99711355 99711532 178 - 0.345 0.000 -11.207
ENSG00000156869 E009 11.9526168 0.0015037566 2.043550e-01 3.316069e-01 1 99712105 99712163 59 - 1.124 0.996 -0.467
ENSG00000156869 E010 17.3361758 0.0012031437 7.172384e-02 1.462193e-01 1 99712418 99712515 98 - 1.287 1.133 -0.548
ENSG00000156869 E011 17.3940290 0.0112144823 3.487107e-02 8.140351e-02 1 99715586 99715672 87 - 1.301 1.094 -0.734
ENSG00000156869 E012 15.4254598 0.0011653423 1.268040e-01 2.297014e-01 1 99717410 99717525 116 - 1.234 1.098 -0.487
ENSG00000156869 E013 14.7008560 0.0012663204 1.426653e-01 2.516512e-01 1 99719534 99719647 114 - 1.213 1.079 -0.480
ENSG00000156869 E014 11.8679027 0.0014969446 2.622033e-03 9.133531e-03 1 99728493 99728640 148 - 1.168 0.830 -1.252
ENSG00000156869 E015 9.7579138 0.0017941114 8.511926e-02 1.676013e-01 1 99729650 99729748 99 - 1.061 0.863 -0.739
ENSG00000156869 E016 20.2076277 0.0010077887 3.462681e-03 1.161875e-02 1 99738086 99738268 183 - 1.366 1.116 -0.882
ENSG00000156869 E017 19.5030550 0.0010143876 2.114246e-02 5.390018e-02 1 99740793 99740940 148 - 1.342 1.149 -0.681
ENSG00000156869 E018 14.5770756 0.0033332308 1.150391e-01 2.128955e-01 1 99742179 99742273 95 - 1.213 1.060 -0.551
ENSG00000156869 E019 16.5051337 0.0016785397 7.653745e-04 3.133802e-03 1 99747294 99747430 137 - 1.301 0.972 -1.179
ENSG00000156869 E020 0.0000000       1 99747595 99748572 978 -      
ENSG00000156869 E021 19.9451438 0.0012081686 9.339007e-04 3.732824e-03 1 99748573 99748768 196 - 1.370 1.079 -1.026
ENSG00000156869 E022 10.2673901 0.0024800918 9.476681e-03 2.748008e-02 1 99748897 99749001 105 - 1.104 0.795 -1.160
ENSG00000156869 E023 0.1451727 0.0493781491 1.000000e+00   1 99765297 99765793 497 - 0.080 0.000 -8.640
ENSG00000156869 E024 3.9900325 0.0042521825 1.321742e-01 2.371324e-01 1 99766607 99766635 29 - 0.736 0.491 -1.082