ENSG00000156860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287468 ENSG00000156860 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRS protein_coding protein_coding 62.01653 89.12099 44.99592 6.421407 0.5018239 -0.9858125 24.597269 47.317759 11.896576 4.0241362 0.8535993 -1.9909280 0.36299167 0.5313000 0.26476667 -0.26653333 7.085744e-08 1.946539e-10 FALSE TRUE
ENST00000356166 ENSG00000156860 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRS protein_coding protein_coding 62.01653 89.12099 44.99592 6.421407 0.5018239 -0.9858125 13.713491 12.585275 14.452199 2.5692310 0.7406487 0.1994042 0.23942917 0.1387333 0.32126667 0.18253333 2.247796e-04 1.946539e-10 FALSE TRUE
ENST00000468966 ENSG00000156860 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRS protein_coding retained_intron 62.01653 89.12099 44.99592 6.421407 0.5018239 -0.9858125 2.905849 1.722541 2.762011 0.2037591 0.1597402 0.6780436 0.05474167 0.0192000 0.06146667 0.04226667 1.946539e-10 1.946539e-10   FALSE
ENST00000498588 ENSG00000156860 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRS protein_coding retained_intron 62.01653 89.12099 44.99592 6.421407 0.5018239 -0.9858125 3.695346 2.063759 3.687145 0.5828475 0.5065393 0.8341633 0.07153333 0.0233000 0.08173333 0.05843333 1.921483e-03 1.946539e-10   FALSE
MSTRG.12479.4 ENSG00000156860 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRS protein_coding   62.01653 89.12099 44.99592 6.421407 0.5018239 -0.9858125 7.829893 12.804925 4.863415 0.8399563 0.6407995 -1.3948199 0.11731667 0.1450333 0.10843333 -0.03660000 3.960493e-01 1.946539e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156860 E001 6.171841 0.0282221827 6.849653e-02 1.408862e-01 16 30658388 30658430 43 + 0.961 0.738 -0.867
ENSG00000156860 E002 582.762792 0.0076565143 5.824446e-10 9.025223e-09 16 30658431 30659706 1276 + 2.867 2.656 -0.700
ENSG00000156860 E003 36.976960 0.0183043282 1.614860e-11 3.249048e-10 16 30659707 30659714 8 + 1.831 1.292 -1.845
ENSG00000156860 E004 203.590828 0.0063175525 3.470607e-15 1.223058e-13 16 30659715 30659917 203 + 2.462 2.154 -1.029
ENSG00000156860 E005 116.287110 0.0002848597 3.624799e-16 1.449973e-14 16 30659918 30659921 4 + 2.178 1.948 -0.770
ENSG00000156860 E006 121.812323 0.0003013524 3.555739e-18 1.829009e-16 16 30659922 30659925 4 + 2.204 1.963 -0.810
ENSG00000156860 E007 200.740818 0.0025302446 1.664378e-09 2.367025e-08 16 30659926 30659977 52 + 2.375 2.213 -0.542
ENSG00000156860 E008 411.047899 0.0048425330 3.004710e-05 1.787793e-04 16 30660263 30660442 180 + 2.652 2.548 -0.347
ENSG00000156860 E009 11.939862 0.0048204753 2.087847e-07 1.994435e-06 16 30660443 30660581 139 + 1.343 0.871 -1.710
ENSG00000156860 E010 215.719709 0.0010753494 3.855821e-04 1.719004e-03 16 30661180 30661215 36 + 2.341 2.283 -0.194
ENSG00000156860 E011 175.957235 0.0002373201 1.762384e-05 1.106583e-04 16 30661304 30661321 18 + 2.263 2.186 -0.258
ENSG00000156860 E012 169.549847 0.0002376098 2.620162e-05 1.580935e-04 16 30661322 30661333 12 + 2.247 2.171 -0.257
ENSG00000156860 E013 33.870691 0.0007663847 2.443433e-11 4.779567e-10 16 30661978 30662419 442 + 1.720 1.362 -1.226
ENSG00000156860 E014 254.170523 0.0001955559 3.245897e-05 1.914761e-04 16 30662420 30662468 49 + 2.408 2.353 -0.181
ENSG00000156860 E015 2.220636 0.0098085055 7.942827e-01 8.685696e-01 16 30662469 30662558 90 + 0.434 0.508 0.375
ENSG00000156860 E016 377.080918 0.0001640045 1.253819e-03 4.822794e-03 16 30662559 30662859 301 + 2.555 2.536 -0.064
ENSG00000156860 E017 1.797429 0.4594458324 4.238049e-01 5.668397e-01 16 30663042 30663102 61 + 0.600 0.336 -1.355
ENSG00000156860 E018 79.547779 0.0004630340 3.957604e-01 5.395464e-01 16 30664215 30664456 242 + 1.818 1.898 0.271
ENSG00000156860 E019 42.071238 0.0006731055 6.915107e-02 1.419673e-01 16 30664457 30664516 60 + 1.491 1.644 0.520
ENSG00000156860 E020 278.804240 0.0008412710 4.509022e-01 5.919263e-01 16 30664715 30664920 206 + 2.364 2.431 0.223
ENSG00000156860 E021 250.292220 0.0045733201 4.971035e-01 6.336529e-01 16 30665035 30665079 45 + 2.311 2.391 0.267
ENSG00000156860 E022 356.454722 0.0041726068 5.999549e-01 7.212777e-01 16 30665306 30665401 96 + 2.469 2.543 0.245
ENSG00000156860 E023 373.754249 0.0024490312 6.458888e-01 7.579486e-01 16 30665638 30665706 69 + 2.494 2.560 0.221
ENSG00000156860 E024 24.261413 0.0024499141 1.104123e-04 5.698912e-04 16 30665975 30666511 537 + 1.515 1.275 -0.833
ENSG00000156860 E025 269.140645 0.0007285109 8.321949e-01 8.948318e-01 16 30666512 30666541 30 + 2.367 2.408 0.136
ENSG00000156860 E026 363.468747 0.0001642715 2.576730e-01 3.948346e-01 16 30666919 30666990 72 + 2.479 2.546 0.226
ENSG00000156860 E027 414.834652 0.0001456832 9.792893e-03 2.825388e-02 16 30667320 30667437 118 + 2.517 2.611 0.315
ENSG00000156860 E028 413.321848 0.0002285502 3.571866e-04 1.608002e-03 16 30667542 30667622 81 + 2.500 2.616 0.388
ENSG00000156860 E029 20.499270 0.0024302346 8.661836e-08 8.899874e-07 16 30667939 30668559 621 + 1.515 1.142 -1.303
ENSG00000156860 E030 421.280832 0.0048149346 1.321350e-01 2.370734e-01 16 30668560 30668643 84 + 2.518 2.627 0.363
ENSG00000156860 E031 21.074605 0.0048829263 5.350052e-06 3.782332e-05 16 30668644 30668771 128 + 1.498 1.173 -1.132
ENSG00000156860 E032 687.271699 0.0016355339 1.980725e-02 5.107493e-02 16 30668772 30668979 208 + 2.729 2.837 0.357
ENSG00000156860 E033 280.580184 0.0017761794 1.287709e-01 2.324465e-01 16 30669069 30669093 25 + 2.347 2.443 0.320
ENSG00000156860 E034 3263.324600 0.0089625716 4.952234e-06 3.527280e-05 16 30669094 30670810 1717 + 3.334 3.541 0.688