ENSG00000156675

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287263 ENSG00000156675 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP1 protein_coding protein_coding 11.78419 11.60555 15.48987 0.7929308 0.2226987 0.4161989 7.392275 9.084443 8.422165 0.5654582 0.5154135 -0.1090821 0.63879583 0.7844333 0.5436000 -0.24083333 1.483365e-04 3.823892e-15 FALSE TRUE
ENST00000330843 ENSG00000156675 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP1 protein_coding protein_coding 11.78419 11.60555 15.48987 0.7929308 0.2226987 0.4161989 3.225633 2.514761 4.373054 0.4338950 0.1970303 0.7957895 0.27473750 0.2150333 0.2827667 0.06773333 3.317319e-01 3.823892e-15 FALSE TRUE
ENST00000522727 ENSG00000156675 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP1 protein_coding protein_coding 11.78419 11.60555 15.48987 0.7929308 0.2226987 0.4161989 1.089702 0.000000 2.636222 0.0000000 0.4721721 8.0477904 0.07948333 0.0000000 0.1699000 0.16990000 3.823892e-15 3.823892e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156675 E001 1518.7147334 0.0076573549 3.168548e-13 8.386029e-12 8 37858618 37862758 4141 - 3.042 3.302 0.866
ENSG00000156675 E002 125.6910518 0.0066557371 3.357499e-01 4.795519e-01 8 37862759 37862894 136 - 2.067 2.135 0.227
ENSG00000156675 E003 143.9345744 0.0008441348 1.592420e-01 2.741019e-01 8 37862895 37863113 219 - 2.123 2.199 0.251
ENSG00000156675 E004 0.2998086 0.0291926540 9.604340e-01   8 37870387 37870419 33 - 0.104 0.143 0.515
ENSG00000156675 E005 85.8767102 0.0008325005 2.620220e-02 6.435962e-02 8 37870420 37870528 109 - 1.927 1.960 0.112
ENSG00000156675 E006 0.8773789 0.3748648049 6.844928e-02 1.408038e-01 8 37870529 37871277 749 - 0.419 0.000 -13.058
ENSG00000156675 E007 187.8413202 0.0061452100 5.252548e-04 2.254014e-03 8 37871278 37873179 1902 - 2.290 2.257 -0.109
ENSG00000156675 E008 0.2924217 0.0274548268 2.260256e-01   8 37873180 37873278 99 - 0.189 0.000 -11.483
ENSG00000156675 E009 310.0746300 0.0034859459 1.969703e-15 7.160898e-14 8 37874515 37875322 808 - 2.550 2.413 -0.459
ENSG00000156675 E010 180.0071149 0.0078217912 4.996523e-10 7.820360e-09 8 37877109 37877551 443 - 2.331 2.148 -0.614
ENSG00000156675 E011 0.1482932 0.0413285918 4.508109e-01   8 37877552 37878117 566 - 0.000 0.143 11.241
ENSG00000156675 E012 56.5556510 0.0233282378 3.957035e-05 2.283147e-04 8 37899071 37899303 233 - 1.854 1.603 -0.852
ENSG00000156675 E013 37.4424319 0.0238602277 1.925249e-05 1.198793e-04 8 37899304 37899497 194 - 1.691 1.403 -0.987