ENSG00000156671

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000542569 ENSG00000156671 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD8 protein_coding protein_coding 4.222365 1.393152 6.027289 0.1138238 0.05799685 2.105229 0.89633949 0.2523981 0.000000 0.25239813 0.0000000 -4.713686 0.31041250 0.21340000 0.0000000 -0.21340000 0.62331441 0.04923332 FALSE  
ENST00000649316 ENSG00000156671 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD8 protein_coding nonsense_mediated_decay 4.222365 1.393152 6.027289 0.1138238 0.05799685 2.105229 0.03169071 0.1112173 0.000000 0.08433874 0.0000000 -3.599524 0.01699583 0.07193333 0.0000000 -0.07193333 0.04923332 0.04923332 TRUE  
ENST00000671800 ENSG00000156671 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD8 protein_coding protein_coding 4.222365 1.393152 6.027289 0.1138238 0.05799685 2.105229 1.74338913 0.7979146 3.941882 0.40505898 0.3242618 2.290265 0.36319583 0.53656667 0.6531000 0.11653333 0.97341715 0.04923332 FALSE  
MSTRG.4221.2 ENSG00000156671 HEK293_OSMI2_2hA HEK293_TMG_2hB SAMD8 protein_coding   4.222365 1.393152 6.027289 0.1138238 0.05799685 2.105229 1.08819479 0.2316223 1.572769 0.10907970 0.1668185 2.711625 0.23015000 0.17810000 0.2614333 0.08333333 0.59388837 0.04923332 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156671 E001 0.0000000       10 75099586 75099728 143 +      
ENSG00000156671 E002 0.9286724 0.0153259883 0.8158180516 0.883434284 10 75111416 75111475 60 + 0.262 0.214 -0.378
ENSG00000156671 E003 1.5176685 0.0422247519 0.3881397173 0.532253641 10 75111476 75111510 35 + 0.397 0.215 -1.225
ENSG00000156671 E004 3.0008790 0.1182505157 0.9002995692 0.940382487 10 75111511 75111634 124 + 0.543 0.554 0.050
ENSG00000156671 E005 4.7554318 0.0040649606 0.2378522067 0.371653514 10 75111635 75111655 21 + 0.652 0.829 0.723
ENSG00000156671 E006 8.6296534 0.0020065899 0.5894291654 0.712496851 10 75111656 75111691 36 + 0.936 0.868 -0.257
ENSG00000156671 E007 9.0725463 0.0018489355 0.2832523711 0.423340470 10 75111692 75111708 17 + 0.968 0.829 -0.529
ENSG00000156671 E008 9.1423769 0.0021048699 0.2569312577 0.393956132 10 75111709 75111722 14 + 0.976 0.829 -0.558
ENSG00000156671 E009 6.4068497 0.0033287511 0.2864186530 0.426802330 10 75111723 75111778 56 + 0.843 0.684 -0.640
ENSG00000156671 E010 6.4937314 0.0025032370 0.5071517271 0.642750691 10 75150514 75150517 4 + 0.833 0.738 -0.377
ENSG00000156671 E011 64.2983695 0.0009019118 0.0045660185 0.014726477 10 75150518 75151106 589 + 1.780 1.628 -0.513
ENSG00000156671 E012 27.7477201 0.0007027728 0.0571907339 0.121789224 10 75164645 75164740 96 + 1.427 1.276 -0.525
ENSG00000156671 E013 30.3618300 0.0043028172 0.5300220995 0.662729339 10 75168541 75168658 118 + 1.445 1.401 -0.152
ENSG00000156671 E014 0.4031496 0.0264107823 0.0218565375 0.055382271 10 75173732 75173763 32 + 0.000 0.358 12.409
ENSG00000156671 E015 40.0100692 0.0005995906 0.8247868304 0.889617974 10 75176066 75176216 151 + 1.552 1.542 -0.036
ENSG00000156671 E016 0.3030308 0.3959614817 1.0000000000   10 75176217 75176387 171 + 0.125 0.000 -9.990
ENSG00000156671 E017 522.0059235 0.0003612716 0.0002577339 0.001207481 10 75176388 75182123 5736 + 2.639 2.679 0.134