ENSG00000156650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287239 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 1.5914834 0.5547903 2.64281458 0.13968439 0.29709797 2.2317367 0.29446667 0.1592000 0.42650000 0.26730000 0.0042039381 0.0001498271 FALSE TRUE
ENST00000372714 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 0.1604541 0.0000000 0.31776284 0.00000000 0.16121101 5.0345804 0.02442917 0.0000000 0.05103333 0.05103333 0.2775343069 0.0001498271 FALSE TRUE
ENST00000372724 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 0.1697766 0.0000000 0.41769771 0.00000000 0.32107520 5.4185196 0.02742083 0.0000000 0.06733333 0.06733333 0.3596009439 0.0001498271 FALSE TRUE
ENST00000648370 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 0.8805091 0.6512516 0.37825157 0.34564864 0.37825157 -0.7682075 0.16886667 0.1793333 0.06250000 -0.11683333 0.5073094255 0.0001498271 FALSE TRUE
ENST00000649006 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 1.0237920 1.8492052 1.04121533 0.09420779 0.20078636 -0.8226278 0.24454583 0.5491333 0.16693333 -0.38220000 0.0001498271 0.0001498271 FALSE TRUE
ENST00000649463 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 0.2299996 0.0000000 0.51266127 0.00000000 0.26791250 5.7078044 0.03292500 0.0000000 0.08116667 0.08116667 0.2694412504 0.0001498271 FALSE TRUE
ENST00000650232 ENSG00000156650 HEK293_OSMI2_2hA HEK293_TMG_2hB KAT6B protein_coding protein_coding 5.006066 3.426433 6.219674 0.2753136 0.09349457 0.8582448 0.2120066 0.0000000 0.05694889 0.00000000 0.05694889 2.7430601 0.05840833 0.0000000 0.00940000 0.00940000 0.8929452914 0.0001498271 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156650 E001 0.0000000       10 74824927 74824935 9 +      
ENSG00000156650 E002 0.1482932 0.0416766396 2.573043e-01   10 74824936 74825254 319 + 0.000 0.184 16.831
ENSG00000156650 E003 0.1482932 0.0416766396 2.573043e-01   10 74825255 74825356 102 + 0.000 0.184 19.025
ENSG00000156650 E004 0.0000000       10 74825357 74825360 4 +      
ENSG00000156650 E005 0.1472490 0.0427924863 9.930931e-01   10 74825484 74825491 8 + 0.079 0.000 -17.942
ENSG00000156650 E006 0.1472490 0.0427924863 9.930931e-01   10 74825492 74825498 7 + 0.079 0.000 -17.942
ENSG00000156650 E007 0.2987644 0.0290785164 4.452729e-01   10 74825499 74825526 28 + 0.146 0.000 -18.972
ENSG00000156650 E008 0.4460135 0.0288970716 2.424123e-01 3.770010e-01 10 74825527 74825534 8 + 0.204 0.000 -19.513
ENSG00000156650 E009 0.4460135 0.0288970716 2.424123e-01 3.770010e-01 10 74825535 74825535 1 + 0.204 0.000 -19.513
ENSG00000156650 E010 1.0673886 0.0595269198 2.562168e-01 3.931917e-01 10 74825536 74825557 22 + 0.342 0.185 -1.179
ENSG00000156650 E011 1.2490930 0.1124516947 6.042861e-01 7.248793e-01 10 74825558 74825567 10 + 0.342 0.314 -0.176
ENSG00000156650 E012 1.1018439 0.0317539900 7.463909e-01 8.341816e-01 10 74825568 74825584 17 + 0.301 0.314 0.084
ENSG00000156650 E013 1.7619408 0.1089831058 9.851084e-01 9.947102e-01 10 74825585 74825613 29 + 0.380 0.495 0.604
ENSG00000156650 E014 2.2800741 0.0096262515 9.183703e-01 9.524311e-01 10 74825614 74825674 61 + 0.447 0.562 0.558
ENSG00000156650 E015 0.1482932 0.0416766396 2.573043e-01   10 74825675 74825766 92 + 0.000 0.184 19.025
ENSG00000156650 E016 0.0000000       10 74826413 74826418 6 +      
ENSG00000156650 E017 0.7363694 0.0204334509 1.015345e-01 1.928111e-01 10 74826419 74826448 30 + 0.079 0.414 2.992
ENSG00000156650 E018 0.9578146 0.0401420147 4.173185e-02 9.424551e-02 10 74826449 74826469 21 + 0.079 0.496 3.414
ENSG00000156650 E019 1.4038281 0.0351802837 3.793888e-01 5.236498e-01 10 74826470 74826551 82 + 0.255 0.496 1.412
ENSG00000156650 E020 0.8189741 0.0220691337 4.926022e-01 6.297457e-01 10 74826552 74826561 10 + 0.255 0.185 -0.594
ENSG00000156650 E021 0.4460135 0.0288970716 2.424123e-01 3.770010e-01 10 74826562 74826579 18 + 0.204 0.000 -19.513
ENSG00000156650 E022 0.9545949 0.0137978691 9.563990e-01 9.766962e-01 10 74826580 74826595 16 + 0.255 0.314 0.405
ENSG00000156650 E023 0.9482522 0.0670689295 9.503923e-01 9.729537e-01 10 74826596 74826599 4 + 0.255 0.314 0.408
ENSG00000156650 E024 0.9482522 0.0670689295 9.503923e-01 9.729537e-01 10 74826600 74826602 3 + 0.255 0.314 0.408
ENSG00000156650 E025 3.1420259 0.0054111938 1.631966e-01 2.793252e-01 10 74826603 74826627 25 + 0.623 0.494 -0.595
ENSG00000156650 E026 2.8475278 0.0357323520 3.030251e-01 4.449411e-01 10 74826628 74826634 7 + 0.580 0.495 -0.398
ENSG00000156650 E027 7.8618590 0.0036695776 2.299637e-02 5.774071e-02 10 74826635 74826785 151 + 0.964 0.799 -0.631
ENSG00000156650 E028 0.0000000       10 74826881 74826943 63 +      
ENSG00000156650 E029 0.0000000       10 74827058 74827114 57 +      
ENSG00000156650 E030 0.0000000       10 74827137 74827270 134 +      
ENSG00000156650 E031 9.7732127 0.0019137718 3.815249e-02 8.764192e-02 10 74838683 74838752 70 + 1.033 0.925 -0.403
ENSG00000156650 E032 0.1515154 0.0425554942 9.928453e-01   10 74838753 74838783 31 + 0.079 0.000 -17.944
ENSG00000156650 E033 7.7127611 0.0022115002 2.724645e-02 6.648976e-02 10 74842600 74842619 20 + 0.954 0.799 -0.595
ENSG00000156650 E034 30.5441541 0.0021915553 4.423934e-07 3.955173e-06 10 74842620 74842863 244 + 1.529 1.291 -0.824
ENSG00000156650 E035 13.4088498 0.0086142338 4.786658e-04 2.078285e-03 10 74842864 74842882 19 + 1.193 0.925 -0.977
ENSG00000156650 E036 68.3993500 0.0004246942 8.673212e-09 1.081494e-07 10 74842883 74843478 596 + 1.844 1.715 -0.436
ENSG00000156650 E037 1.4371390 0.0093006607 1.997323e-01 3.259006e-01 10 74843479 74847290 3812 + 0.255 0.562 1.725
ENSG00000156650 E038 0.0000000       10 74907165 74907546 382 +      
ENSG00000156650 E039 0.0000000       10 74908488 74908597 110 +      
ENSG00000156650 E040 22.7845699 0.0569551517 2.015857e-01 3.281588e-01 10 74959970 74960078 109 + 1.354 1.327 -0.093
ENSG00000156650 E041 0.2214452 0.0408371870 2.553997e-01   10 74960079 74962584 2506 + 0.000 0.185 19.036
ENSG00000156650 E042 24.2465513 0.0739913867 1.004782e-01 1.911845e-01 10 74969660 74969775 116 + 1.390 1.321 -0.239
ENSG00000156650 E043 0.1451727 0.0427825729 9.929090e-01   10 74969776 74970019 244 + 0.079 0.000 -17.942
ENSG00000156650 E044 21.6241327 0.0008894671 3.310375e-02 7.801614e-02 10 74970020 74970101 82 + 1.334 1.302 -0.112
ENSG00000156650 E045 0.0000000       10 74970102 74970750 649 +      
ENSG00000156650 E046 26.0374017 0.0009248731 9.463783e-03 2.744646e-02 10 74972507 74972639 133 + 1.418 1.366 -0.181
ENSG00000156650 E047 18.7020831 0.0025241619 5.110154e-02 1.111338e-01 10 74975399 74975454 56 + 1.274 1.241 -0.117
ENSG00000156650 E048 34.4690601 0.0007289872 4.129812e-03 1.350562e-02 10 74975455 74975781 327 + 1.531 1.487 -0.154
ENSG00000156650 E049 17.7629960 0.0010122702 2.778315e-04 1.289394e-03 10 74975782 74975945 164 + 1.297 1.102 -0.691
ENSG00000156650 E050 27.5413659 0.0007980777 3.778387e-10 6.050753e-09 10 74975946 74976330 385 + 1.511 1.153 -1.247
ENSG00000156650 E051 0.5858876 0.0202388241 6.969758e-01 7.972176e-01 10 74976331 74976520 190 + 0.204 0.184 -0.182
ENSG00000156650 E052 1.4079822 0.0104374496 9.505823e-01 9.730512e-01 10 74976521 74977315 795 + 0.342 0.413 0.404
ENSG00000156650 E053 23.6378984 0.0008279162 2.188630e-02 5.543915e-02 10 74977316 74977437 122 + 1.373 1.335 -0.130
ENSG00000156650 E054 21.2711516 0.0010105799 1.282263e-01 2.316776e-01 10 74979224 74979339 116 + 1.310 1.325 0.053
ENSG00000156650 E055 23.9295024 0.0069934907 4.918174e-02 1.077011e-01 10 74981787 74981928 142 + 1.376 1.346 -0.107
ENSG00000156650 E056 0.6674587 0.0253924769 7.006898e-01 8.001035e-01 10 74981929 74985079 3151 + 0.204 0.185 -0.178
ENSG00000156650 E057 31.0554991 0.0007993445 3.842022e-04 1.713619e-03 10 74985080 74985241 162 + 1.508 1.404 -0.358
ENSG00000156650 E058 0.4502799 0.0265853882 2.420874e-01 3.766619e-01 10 74985329 74989018 3690 + 0.204 0.000 -19.527
ENSG00000156650 E059 25.0086570 0.0008211880 6.789073e-03 2.067452e-02 10 74989019 74989112 94 + 1.401 1.336 -0.229
ENSG00000156650 E060 0.0000000       10 74989113 74989957 845 +      
ENSG00000156650 E061 0.1515154 0.0425554942 9.928453e-01   10 75017475 75019502 2028 + 0.079 0.000 -17.944
ENSG00000156650 E062 0.1515154 0.0425554942 9.928453e-01   10 75019503 75019637 135 + 0.079 0.000 -17.944
ENSG00000156650 E063 0.1817044 0.0385001237 2.571362e-01   10 75019638 75020581 944 + 0.000 0.185 19.049
ENSG00000156650 E064 42.3204035 0.0006044826 1.001154e-01 1.906523e-01 10 75020582 75020813 232 + 1.591 1.637 0.157
ENSG00000156650 E065 37.8024287 0.0006226087 9.877083e-01 9.963970e-01 10 75021126 75021285 160 + 1.511 1.648 0.468
ENSG00000156650 E066 0.1451727 0.0427825729 9.929090e-01   10 75021286 75021880 595 + 0.079 0.000 -17.942
ENSG00000156650 E067 59.2607141 0.0016745102 1.600421e-01 2.751607e-01 10 75021881 75022231 351 + 1.726 1.795 0.235
ENSG00000156650 E068 0.4438354 0.1188148912 2.911640e-01 4.319950e-01 10 75022232 75024232 2001 + 0.079 0.311 2.386
ENSG00000156650 E069 72.7975123 0.0004444806 3.189302e-03 1.082395e-02 10 75024958 75025249 292 + 1.833 1.844 0.039
ENSG00000156650 E070 1.6221673 0.0091739054 7.733848e-01 8.537798e-01 10 75025250 75026164 915 + 0.380 0.413 0.183
ENSG00000156650 E071 589.8774982 0.0113385331 3.576063e-12 8.011470e-11 10 75028489 75032624 4136 + 2.600 2.943 1.143