ENSG00000156599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287169 ENSG00000156599 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC5 protein_coding protein_coding 38.99226 39.78574 38.4502 2.081011 0.5477312 -0.04924753 22.205541 22.436444 21.2505582 1.5044896 0.9846408 -0.078307404 0.57130000 0.5637333 0.553566667 -0.010166667 0.95952229 7.969191e-08 FALSE TRUE
MSTRG.5521.13 ENSG00000156599 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC5 protein_coding   38.99226 39.78574 38.4502 2.081011 0.5477312 -0.04924753 3.685932 10.600498 0.1978677 2.7778827 0.1978677 -5.673682985 0.09257917 0.2690667 0.005266667 -0.263800000 0.00231194 7.969191e-08 FALSE TRUE
MSTRG.5521.3 ENSG00000156599 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC5 protein_coding   38.99226 39.78574 38.4502 2.081011 0.5477312 -0.04924753 2.730468 2.868049 2.8631710 0.5909668 0.3678456 -0.002447172 0.06907500 0.0723000 0.074266667 0.001966667 0.96074078 7.969191e-08 FALSE TRUE
MSTRG.5521.5 ENSG00000156599 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC5 protein_coding   38.99226 39.78574 38.4502 2.081011 0.5477312 -0.04924753 6.431192 1.174831 8.5512186 1.1748311 1.3136965 2.853134694 0.16687917 0.0273000 0.221533333 0.194233333 0.05328991 7.969191e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156599 E001 0.1472490 0.0433248931 4.468124e-01   11 57667597 57667746 150 + 0.125 0.000 -8.902
ENSG00000156599 E002 9.7580763 0.0603431061 4.768239e-03 1.528423e-02 11 57667747 57667909 163 + 1.214 0.803 -1.520
ENSG00000156599 E003 13.5202139 0.0030148011 2.936644e-04 1.354017e-03 11 57667910 57667936 27 + 1.309 0.995 -1.122
ENSG00000156599 E004 29.3886303 0.0183800352 1.603239e-08 1.902347e-07 11 57667937 57668047 111 + 1.691 1.185 -1.748
ENSG00000156599 E005 37.4499285 0.0296381499 1.950179e-05 1.213153e-04 11 57668048 57668104 57 + 1.761 1.352 -1.399
ENSG00000156599 E006 25.4150742 0.0568730904 7.037804e-03 2.132310e-02 11 57668105 57668113 9 + 1.569 1.242 -1.130
ENSG00000156599 E007 106.5706532 0.0080954316 1.717593e-05 1.081363e-04 11 57668114 57668187 74 + 2.134 1.921 -0.713
ENSG00000156599 E008 1.9489281 0.0095529186 4.673874e-01 6.068884e-01 11 57668292 57668407 116 + 0.368 0.509 0.739
ENSG00000156599 E009 2.0252006 0.0724894453 2.108205e-01 3.395270e-01 11 57668450 57668596 147 + 0.301 0.554 1.368
ENSG00000156599 E010 371.0843257 0.0067289816 7.825303e-06 5.327297e-05 11 57672021 57672418 398 + 2.652 2.487 -0.550
ENSG00000156599 E011 714.8541087 0.0030772707 1.600930e-03 5.964198e-03 11 57672419 57673143 725 + 2.886 2.822 -0.212
ENSG00000156599 E012 198.1975815 0.0002994764 3.143637e-02 7.475883e-02 11 57673144 57673194 51 + 2.313 2.282 -0.102
ENSG00000156599 E013 0.4449813 0.0214820821 5.068497e-01 6.424882e-01 11 57681479 57681698 220 + 0.222 0.120 -1.073
ENSG00000156599 E014 253.6221251 0.0003374209 1.870320e-05 1.167969e-04 11 57682422 57682539 118 + 2.444 2.370 -0.247
ENSG00000156599 E015 106.8833696 0.0015119441 3.026765e-04 1.390426e-03 11 57682540 57682543 4 + 2.091 1.979 -0.378
ENSG00000156599 E016 0.1451727 0.0432831794 4.469714e-01   11 57687836 57687913 78 + 0.125 0.000 -10.798
ENSG00000156599 E017 271.3442655 0.0015716513 5.319861e-03 1.680336e-02 11 57688508 57688665 158 + 2.462 2.408 -0.180
ENSG00000156599 E018 315.1760150 0.0001716641 1.360014e-02 3.730660e-02 11 57690031 57690203 173 + 2.511 2.487 -0.082
ENSG00000156599 E019 5.0542162 0.0033493991 6.653580e-01 7.730478e-01 11 57690204 57690334 131 + 0.727 0.806 0.317
ENSG00000156599 E020 272.4744130 0.0015627723 2.265187e-01 3.582507e-01 11 57690335 57690437 103 + 2.439 2.430 -0.032
ENSG00000156599 E021 316.4616972 0.0017492615 3.078907e-01 4.501213e-01 11 57692611 57692702 92 + 2.501 2.498 -0.010
ENSG00000156599 E022 370.1343629 0.0001428327 2.253098e-01 3.567845e-01 11 57693783 57693915 133 + 2.540 2.588 0.160
ENSG00000156599 E023 312.7131081 0.0005315908 3.518201e-01 4.960242e-01 11 57695920 57696043 124 + 2.469 2.514 0.152
ENSG00000156599 E024 247.4593125 0.0008503287 7.390992e-01 8.288059e-01 11 57696761 57696873 113 + 2.385 2.401 0.054
ENSG00000156599 E025 1247.2849614 0.0009852214 7.141489e-04 2.949367e-03 11 57698559 57699418 860 + 3.049 3.127 0.257
ENSG00000156599 E026 719.7225514 0.0033399236 1.984977e-04 9.574253e-04 11 57699866 57700397 532 + 2.777 2.909 0.439
ENSG00000156599 E027 701.9894722 0.0111270986 1.360214e-06 1.097668e-05 11 57700398 57701344 947 + 2.678 2.942 0.879
ENSG00000156599 E028 1.7295607 0.0079786706 6.338645e-01 7.484697e-01 11 57704706 57704816 111 + 0.477 0.413 -0.335