ENSG00000156535

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287097 ENSG00000156535 HEK293_OSMI2_2hA HEK293_TMG_2hB CD109 protein_coding protein_coding 0.9413737 0.2934788 1.787331 0.04271288 0.1852866 2.566189 0.47835299 0.26123912 0.9180524 0.01111838 0.05414114 1.774641 0.61240000 0.9148 0.51990000 -0.394900000 0.015357154 0.001773294 FALSE TRUE
ENST00000422508 ENSG00000156535 HEK293_OSMI2_2hA HEK293_TMG_2hB CD109 protein_coding protein_coding 0.9413737 0.2934788 1.787331 0.04271288 0.1852866 2.566189 0.05606313 0.00000000 0.0641510 0.00000000 0.06415100 2.890466 0.10500417 0.0000 0.03593333 0.035933333 1.000000000 0.001773294 FALSE TRUE
ENST00000437994 ENSG00000156535 HEK293_OSMI2_2hA HEK293_TMG_2hB CD109 protein_coding protein_coding 0.9413737 0.2934788 1.787331 0.04271288 0.1852866 2.566189 0.05452611 0.03223964 0.1389522 0.03223964 0.07563483 1.818181 0.06464167 0.0852 0.08386667 -0.001333333 0.984889793 0.001773294 FALSE TRUE
ENST00000649530 ENSG00000156535 HEK293_OSMI2_2hA HEK293_TMG_2hB CD109 protein_coding processed_transcript 0.9413737 0.2934788 1.787331 0.04271288 0.1852866 2.566189 0.35243144 0.00000000 0.6661752 0.00000000 0.17894149 6.079325 0.21795833 0.0000 0.36033333 0.360333333 0.001773294 0.001773294 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156535 E001 2.6560324 0.0257761582 8.536995e-01 9.094738e-01 6 73695785 73696202 418 + 0.518 0.486 -0.153
ENSG00000156535 E002 3.7902554 0.0089689058 4.676734e-01 6.071691e-01 6 73696203 73696289 87 + 0.592 0.711 0.511
ENSG00000156535 E003 8.0332849 0.0034447879 5.739518e-01 6.998580e-01 6 73697400 73697572 173 + 0.897 0.815 -0.317
ENSG00000156535 E004 0.0000000       6 73722941 73723159 219 +      
ENSG00000156535 E005 5.2561914 0.0141959808 7.974807e-01 8.707800e-01 6 73723251 73723279 29 + 0.723 0.765 0.169
ENSG00000156535 E006 11.1430219 0.0029008892 8.680949e-02 1.702939e-01 6 73730344 73730574 231 + 1.046 0.815 -0.869
ENSG00000156535 E007 7.0892872 0.0024261383 6.389730e-02 1.331890e-01 6 73736383 73736508 126 + 0.880 0.576 -1.251
ENSG00000156535 E008 3.7019804 0.0042285924 3.336472e-02 7.851106e-02 6 73756643 73756682 40 + 0.670 0.228 -2.410
ENSG00000156535 E009 4.6581000 0.0566831730 1.031836e-01 1.953240e-01 6 73758944 73759028 85 + 0.737 0.377 -1.691
ENSG00000156535 E010 4.5839012 0.0613519048 5.950205e-01 7.171750e-01 6 73762384 73762480 97 + 0.699 0.575 -0.533
ENSG00000156535 E011 5.8797431 0.0029162333 9.476006e-01 9.710349e-01 6 73762741 73762882 142 + 0.759 0.767 0.028
ENSG00000156535 E012 6.7196599 0.0180766791 2.732796e-01 4.122861e-01 6 73763576 73763685 110 + 0.843 0.650 -0.785
ENSG00000156535 E013 10.7442615 0.0256636190 5.373080e-01 6.689105e-01 6 73765930 73766154 225 + 1.008 0.900 -0.404
ENSG00000156535 E014 6.5473196 0.0025843117 9.380936e-02 1.810762e-01 6 73766759 73766860 102 + 0.853 0.576 -1.148
ENSG00000156535 E015 5.1046640 0.0032510636 6.011051e-01 7.222520e-01 6 73766948 73767010 63 + 0.736 0.649 -0.362
ENSG00000156535 E016 7.5992904 0.0026126395 9.914562e-01 9.987314e-01 6 73768055 73768231 177 + 0.862 0.859 -0.013
ENSG00000156535 E017 7.5319766 0.0022676685 4.410739e-01 5.827147e-01 6 73771429 73771581 153 + 0.880 0.766 -0.444
ENSG00000156535 E018 6.8543894 0.0024022102 7.170445e-02 1.461876e-01 6 73780424 73780498 75 + 0.871 0.576 -1.218
ENSG00000156535 E019 6.7008994 0.0024200696 5.870946e-03 1.827317e-02 6 73781259 73781319 61 + 0.880 0.377 -2.251
ENSG00000156535 E020 9.3453777 0.0019041277 2.444811e-02 6.074656e-02 6 73782614 73782755 142 + 0.988 0.649 -1.336
ENSG00000156535 E021 8.4608514 0.0021245290 1.287743e-01 2.324505e-01 6 73783707 73783824 118 + 0.937 0.712 -0.884
ENSG00000156535 E022 7.0109357 0.0032605036 3.642673e-01 5.086335e-01 6 73785364 73785477 114 + 0.853 0.712 -0.562
ENSG00000156535 E023 10.4173337 0.0020994371 8.788344e-01 9.261642e-01 6 73787234 73787452 219 + 0.988 0.968 -0.074
ENSG00000156535 E024 7.9137351 0.0349569710 6.567591e-01 7.662479e-01 6 73788468 73788612 145 + 0.889 0.813 -0.294
ENSG00000156535 E025 4.6712208 0.0270873549 7.738224e-01 8.540986e-01 6 73792626 73792654 29 + 0.670 0.712 0.176
ENSG00000156535 E026 8.2268825 0.0042834857 5.301378e-01 6.627973e-01 6 73792655 73792802 148 + 0.906 0.815 -0.349
ENSG00000156535 E027 7.5857147 0.1481410872 1.947986e-01 3.197506e-01 6 73803220 73803301 82 + 0.907 0.637 -1.083
ENSG00000156535 E028 0.1482932 0.0411597534 8.816095e-02   6 73803966 73804076 111 + 0.000 0.228 11.567
ENSG00000156535 E029 13.8563544 0.0013528811 2.547066e-02 6.284795e-02 6 73806844 73807072 229 + 1.137 0.859 -1.030
ENSG00000156535 E030 11.7231966 0.0238965491 6.792202e-01 7.834885e-01 6 73808083 73808248 166 + 1.040 0.968 -0.266
ENSG00000156535 E031 11.4977961 0.0050972662 6.116701e-01 7.307524e-01 6 73809984 73810174 191 + 1.033 0.968 -0.241
ENSG00000156535 E032 8.0149717 0.0486617922 6.818466e-01 7.854468e-01 6 73810992 73811096 105 + 0.870 0.931 0.232
ENSG00000156535 E033 6.7356883 0.0171268549 6.942235e-01 7.951017e-01 6 73811097 73811147 51 + 0.803 0.858 0.216
ENSG00000156535 E034 6.2948596 0.0511625938 7.875751e-01 8.639275e-01 6 73812205 73812270 66 + 0.781 0.815 0.133
ENSG00000156535 E035 10.4610875 0.0017439613 8.143577e-01 8.823680e-01 6 73814981 73815123 143 + 0.974 1.000 0.094
ENSG00000156535 E036 14.0477774 0.0013170431 1.392079e-01 2.469767e-01 6 73818388 73818535 148 + 1.063 1.210 0.526
ENSG00000156535 E037 8.6320438 0.0026783194 5.539283e-02 1.186626e-01 6 73820461 73820563 103 + 0.853 1.081 0.852
ENSG00000156535 E038 72.5303415 0.0004802687 1.685229e-12 3.978338e-11 6 73823458 73828316 4859 + 1.707 1.990 0.955