ENSG00000156531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332070 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 5.8283573 0.2993020 8.122530 0.2993020 0.2111292 4.716616 0.20910417 0.04636667 0.21070000 0.16433333 0.10833950 0.002245479 FALSE TRUE
ENST00000370803 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 10.6769726 2.6109800 17.387434 1.1516830 1.1519634 2.730696 0.43169583 0.36603333 0.44976667 0.08373333 0.82184581 0.002245479 FALSE TRUE
ENST00000625464 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 5.2069059 1.4991909 9.586504 0.4076230 2.1718018 2.668734 0.18128750 0.19923333 0.24613333 0.04690000 0.80812602 0.002245479 FALSE TRUE
ENST00000687496 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 1.9978850 0.3595752 2.627713 0.3595752 0.1592026 2.835348 0.06977083 0.03933333 0.06793333 0.02860000 0.34763045 0.002245479 FALSE TRUE
ENST00000688598 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 0.2901521 1.4762542 0.000000 0.7408988 0.0000000 -7.215537 0.03535000 0.17880000 0.00000000 -0.17880000 0.04619241 0.002245479 FALSE TRUE
ENST00000691812 ENSG00000156531 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF6 protein_coding protein_coding 24.9549 7.729615 38.70926 0.7775985 1.358763 2.322718 0.2339315 1.0965439 0.000000 1.0965439 0.0000000 -6.789917 0.02677917 0.11996667 0.00000000 -0.11996667 0.55964503 0.002245479 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156531 E001 0.6277178 0.0303162156 6.100666e-01 7.294393e-01 X 134373288 134373289 2 + 0.123 0.294 1.563
ENSG00000156531 E002 1.0695787 0.0115911757 9.902516e-01 9.980211e-01 X 134373290 134373299 10 + 0.219 0.294 0.563
ENSG00000156531 E003 3.5869966 0.0043279540 2.930185e-01 4.340530e-01 X 134373300 134373311 12 + 0.532 0.468 -0.312
ENSG00000156531 E004 5.0380582 0.0032476835 1.606540e-02 4.288129e-02 X 134373312 134373319 8 + 0.663 0.294 -1.897
ENSG00000156531 E005 9.5553230 0.0021323553 1.482073e-01 2.592416e-01 X 134373320 134373326 7 + 0.866 0.833 -0.125
ENSG00000156531 E006 18.0305454 0.0040703653 2.306623e-02 5.788902e-02 X 134373327 134373333 7 + 1.115 1.029 -0.311
ENSG00000156531 E007 24.6233303 0.0037284183 2.258020e-03 8.024294e-03 X 134373334 134373340 7 + 1.246 1.101 -0.514
ENSG00000156531 E008 81.7913815 0.0084172689 5.390764e-08 5.769528e-07 X 134373341 134373372 32 + 1.757 1.519 -0.810
ENSG00000156531 E009 145.0814210 0.0233903019 3.804891e-05 2.204898e-04 X 134373373 134373467 95 + 1.996 1.829 -0.559
ENSG00000156531 E010 197.4299876 0.0164911701 1.782912e-06 1.401990e-05 X 134377572 134377755 184 + 2.127 1.972 -0.522
ENSG00000156531 E011 108.9832804 0.0002537624 2.250677e-12 5.213793e-11 X 134378005 134378106 102 + 1.874 1.703 -0.581
ENSG00000156531 E012 0.0000000       X 134381515 134381589 75 +      
ENSG00000156531 E013 0.2965864 0.0920842197 1.382905e-02   X 134382857 134383060 204 + 0.000 0.465 16.928
ENSG00000156531 E014 0.4428904 0.4607429934 3.469836e-02 8.107008e-02 X 134385183 134390310 5128 + 0.000 0.483 17.019
ENSG00000156531 E015 158.9735602 0.0002263433 8.053435e-15 2.686563e-13 X 134393501 134393634 134 + 2.032 1.900 -0.443
ENSG00000156531 E016 117.7972910 0.0003262726 1.631767e-10 2.777228e-09 X 134393909 134393952 44 + 1.901 1.786 -0.390
ENSG00000156531 E017 1.1198269 0.0667280909 1.072937e-01 2.015376e-01 X 134393953 134394160 208 + 0.158 0.591 2.727
ENSG00000156531 E018 1.0393871 0.0263126740 5.387573e-02 1.160342e-01 X 134394161 134394228 68 + 0.123 0.593 3.151
ENSG00000156531 E019 21.1036238 0.0009064583 1.730317e-20 1.171563e-18 X 134394229 134397098 2870 + 0.897 1.813 3.215
ENSG00000156531 E020 20.2835049 0.0014317781 1.622527e-04 8.016451e-04 X 134413488 134413490 3 + 1.179 0.891 -1.056
ENSG00000156531 E021 196.3923347 0.0002160840 7.366439e-14 2.133868e-12 X 134413491 134413657 167 + 2.117 2.040 -0.259
ENSG00000156531 E022 189.9550103 0.0095176049 1.216552e-03 4.696227e-03 X 134413823 134413966 144 + 2.092 2.105 0.044
ENSG00000156531 E023 166.3510911 0.0002260999 6.682929e-08 7.023137e-07 X 134415016 134415120 105 + 2.038 2.032 -0.020
ENSG00000156531 E024 0.9317929 0.0744168563 3.042053e-01 4.462176e-01 X 134415121 134415292 172 + 0.158 0.467 2.141
ENSG00000156531 E025 189.8679010 0.0132700518 1.347136e-03 5.133479e-03 X 134417169 134417302 134 + 2.095 2.085 -0.033
ENSG00000156531 E026 1.3263991 0.0682845434 7.240618e-01 8.177032e-01 X 134417303 134420323 3021 + 0.273 0.293 0.143
ENSG00000156531 E027 183.6776749 0.0002562456 2.382417e-09 3.295428e-08 X 134425201 134425330 130 + 2.082 2.062 -0.067
ENSG00000156531 E028 61.6035015 0.0025430873 2.587891e-01 3.961123e-01 X 134425331 134425660 330 + 1.569 1.849 0.951
ENSG00000156531 E029 376.1504326 0.0037920430 3.921040e-03 1.292079e-02 X 134425661 134426161 501 + 2.376 2.477 0.336
ENSG00000156531 E030 1378.7382154 0.0238119609 4.187081e-09 5.528120e-08 X 134426162 134428791 2630 + 2.862 3.331 1.561