ENSG00000156515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359426 ENSG00000156515 HEK293_OSMI2_2hA HEK293_TMG_2hB HK1 protein_coding protein_coding 67.00639 108.8513 42.07873 5.497449 0.1769893 -1.370986 63.216842 98.940831 40.67538 6.589221 0.361317 -1.282201 0.9551917 0.90860000 0.9666333 0.05803333 1.696885e-01 4.817001e-09 FALSE  
ENST00000470050 ENSG00000156515 HEK293_OSMI2_2hA HEK293_TMG_2hB HK1 protein_coding processed_transcript 67.00639 108.8513 42.07873 5.497449 0.1769893 -1.370986 2.628196 8.843567 0.00000 3.769476 0.000000 -9.790115 0.0245875 0.08163333 0.0000000 -0.08163333 4.817001e-09 4.817001e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156515 E001 0.0000000       10 69269984 69269999 16 +      
ENSG00000156515 E002 0.0000000       10 69270000 69270004 5 +      
ENSG00000156515 E003 0.0000000       10 69270005 69270026 22 +      
ENSG00000156515 E004 0.0000000       10 69270027 69270108 82 +      
ENSG00000156515 E005 0.0000000       10 69271007 69271096 90 +      
ENSG00000156515 E006 0.0000000       10 69278496 69278523 28 +      
ENSG00000156515 E007 0.0000000       10 69278524 69278527 4 +      
ENSG00000156515 E008 0.0000000       10 69278528 69278584 57 +      
ENSG00000156515 E009 0.0000000       10 69278585 69278785 201 +      
ENSG00000156515 E010 0.0000000       10 69282529 69282554 26 +      
ENSG00000156515 E011 0.0000000       10 69282555 69282650 96 +      
ENSG00000156515 E012 0.0000000       10 69282651 69282704 54 +      
ENSG00000156515 E013 0.0000000       10 69288671 69288770 100 +      
ENSG00000156515 E014 0.0000000       10 69292258 69292350 93 +      
ENSG00000156515 E015 0.0000000       10 69295633 69295680 48 +      
ENSG00000156515 E016 0.0000000       10 69296205 69296326 122 +      
ENSG00000156515 E017 0.0000000       10 69300769 69300861 93 +      
ENSG00000156515 E018 0.1482932 0.0411398917 1.000000e+00   10 69315785 69316014 230 + 0.000 0.080 8.078
ENSG00000156515 E019 2.3530227 0.0063112701 4.744133e-01 6.132423e-01 10 69318809 69318846 38 + 0.558 0.451 -0.516
ENSG00000156515 E020 3.5708799 0.0373898455 1.658311e-01 2.827817e-01 10 69318847 69318852 6 + 0.756 0.538 -0.941
ENSG00000156515 E021 6.1667565 0.0545426067 2.361239e-02 5.901290e-02 10 69318853 69318856 4 + 1.018 0.675 -1.337
ENSG00000156515 E022 265.4044535 0.0066604261 2.940145e-03 1.008803e-02 10 69318857 69319010 154 + 2.439 2.329 -0.369
ENSG00000156515 E023 1.2449377 0.0172682658 9.253168e-01 9.569792e-01 10 69319011 69319177 167 + 0.311 0.304 -0.039
ENSG00000156515 E024 0.2924217 0.0293308716 4.246484e-02   10 69338020 69338308 289 + 0.311 0.000 -12.074
ENSG00000156515 E025 0.0000000       10 69338498 69338676 179 +      
ENSG00000156515 E026 512.4459605 0.0028332420 3.501318e-06 2.582798e-05 10 69343827 69343989 163 + 2.729 2.613 -0.387
ENSG00000156515 E027 596.8198496 0.0028044876 3.450031e-04 1.560012e-03 10 69359897 69360045 149 + 2.770 2.688 -0.272
ENSG00000156515 E028 543.8930796 0.0008104870 4.704933e-07 4.183299e-06 10 69364783 69364902 120 + 2.731 2.648 -0.277
ENSG00000156515 E029 555.0346116 0.0002320632 3.242661e-10 5.247394e-09 10 69368536 69368631 96 + 2.743 2.656 -0.291
ENSG00000156515 E030 583.2421392 0.0001173120 5.583757e-11 1.027914e-09 10 69369237 69369336 100 + 2.763 2.679 -0.281
ENSG00000156515 E031 827.6495683 0.0001273908 3.044716e-12 6.906277e-11 10 69369441 69369624 184 + 2.908 2.833 -0.248
ENSG00000156515 E032 661.2366855 0.0019123143 1.382129e-01 2.455988e-01 10 69376934 69377089 156 + 2.765 2.752 -0.046
ENSG00000156515 E033 762.8250469 0.0019556101 7.010025e-01 8.003453e-01 10 69379862 69380095 234 + 2.806 2.820 0.047
ENSG00000156515 E034 930.2199071 0.0001075209 2.110594e-01 3.397812e-01 10 69382487 69382791 305 + 2.898 2.905 0.023
ENSG00000156515 E035 676.9835061 0.0001173649 8.244245e-01 8.893942e-01 10 69384333 69384481 149 + 2.751 2.771 0.068
ENSG00000156515 E036 5.6024393 0.0028777176 1.336633e-02 3.677279e-02 10 69384482 69384795 314 + 0.971 0.668 -1.194
ENSG00000156515 E037 727.8448275 0.0001321568 3.936546e-01 5.375400e-01 10 69384796 69384915 120 + 2.768 2.805 0.124
ENSG00000156515 E038 773.3872932 0.0006848766 8.707214e-01 9.209015e-01 10 69386323 69386418 96 + 2.807 2.827 0.066
ENSG00000156515 E039 2.2810140 0.0066443359 3.268557e-01 4.702947e-01 10 69386419 69386791 373 + 0.311 0.509 1.095
ENSG00000156515 E040 753.4113293 0.0002055071 1.604176e-01 2.756915e-01 10 69389197 69389296 100 + 2.809 2.811 0.005
ENSG00000156515 E041 908.6232035 0.0002356052 5.725720e-01 6.986658e-01 10 69392125 69392278 154 + 2.881 2.896 0.050
ENSG00000156515 E042 492.8404056 0.0014880295 1.514906e-02 4.082483e-02 10 69392279 69392308 30 + 2.560 2.648 0.290
ENSG00000156515 E043 842.4064956 0.0014508147 3.057881e-03 1.043626e-02 10 69394950 69395105 156 + 2.790 2.880 0.302
ENSG00000156515 E044 973.8624885 0.0013605950 1.898648e-08 2.223347e-07 10 69398595 69398828 234 + 2.808 2.955 0.487
ENSG00000156515 E045 2079.4232586 0.0033771192 1.127576e-11 2.328238e-10 10 69400991 69401884 894 + 3.087 3.294 0.689