ENSG00000156508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000488500 ENSG00000156508 HEK293_OSMI2_2hA HEK293_TMG_2hB EEF1A1 protein_coding retained_intron 5207.306 3453.027 7520.88 749.27 266.8424 1.123038 734.2597 533.06156 1277.9243 93.565408 84.91614 1.2614126 0.1402292 0.1571 0.16996667 0.01286667 7.329610e-01 1.741728e-18 FALSE TRUE
ENST00000676710 ENSG00000156508 HEK293_OSMI2_2hA HEK293_TMG_2hB EEF1A1 protein_coding protein_coding 5207.306 3453.027 7520.88 749.27 266.8424 1.123038 3741.9076 2736.70359 5096.3669 622.566806 176.95641 0.8970275 0.7301708 0.7895 0.67766667 -0.11183333 1.026947e-09 1.741728e-18 FALSE TRUE
ENST00000678515 ENSG00000156508 HEK293_OSMI2_2hA HEK293_TMG_2hB EEF1A1 protein_coding protein_coding 5207.306 3453.027 7520.88 749.27 266.8424 1.123038 365.2491 60.71738 632.6658 5.878767 92.37046 3.3810472 0.0571750 0.0191 0.08403333 0.06493333 9.796398e-06 1.741728e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156508 E001 0.000000e+00       6 73489308 73492024 2717 -      
ENSG00000156508 E002 2.998086e-01 2.776470e-02 6.328522e-01   6 73492025 73492339 315 - 0.090 0.163 0.980
ENSG00000156508 E003 2.987644e-01 2.767608e-02 4.757888e-01   6 73492340 73492687 348 - 0.165 0.000 -8.936
ENSG00000156508 E004 1.047821e+00 2.372095e-01 7.843972e-01 8.616902e-01 6 73492688 73492804 117 - 0.335 0.277 -0.380
ENSG00000156508 E005 3.762138e+00 4.575500e-03 1.895663e-01 3.132136e-01 6 73515750 73515764 15 - 0.577 0.781 0.858
ENSG00000156508 E006 4.319942e+02 2.136971e-04 5.029152e-06 3.577992e-05 6 73515765 73517514 1750 - 2.657 2.583 -0.247
ENSG00000156508 E007 5.292035e+02 6.029070e-03 1.475062e-12 3.515931e-11 6 73517515 73517518 4 - 2.576 2.876 0.997
ENSG00000156508 E008 5.614203e+02 5.786098e-03 4.265771e-14 1.278699e-12 6 73517519 73517520 2 - 2.594 2.907 1.043
ENSG00000156508 E009 6.021981e+02 6.210001e-03 2.234038e-14 6.978265e-13 6 73517521 73517521 1 - 2.616 2.943 1.089
ENSG00000156508 E010 5.340032e+03 1.795190e-03 8.038796e-19 4.492407e-17 6 73517522 73517770 249 - 3.635 3.822 0.619
ENSG00000156508 E011 2.008641e+04 5.407518e-04 2.396711e-15 8.627205e-14 6 73517771 73517934 164 - 4.254 4.345 0.301
ENSG00000156508 E012 6.282752e+01 1.998332e-03 3.113579e-01 4.538069e-01 6 73517935 73518029 95 - 1.812 1.773 -0.131
ENSG00000156508 E013 4.695242e+04 9.160114e-04 7.145671e-10 1.090395e-08 6 73518030 73518249 220 - 4.626 4.708 0.273
ENSG00000156508 E014 2.525586e+04 1.457296e-03 1.005094e-05 6.675270e-05 6 73518250 73518264 15 - 4.358 4.437 0.262
ENSG00000156508 E015 9.143733e+01 3.928388e-03 2.676014e-01 4.059242e-01 6 73518265 73518353 89 - 1.974 1.935 -0.133
ENSG00000156508 E016 5.200430e+04 2.019794e-04 7.283896e-22 5.709194e-20 6 73518354 73518610 257 - 4.681 4.740 0.196
ENSG00000156508 E017 4.120763e+04 3.427937e-05 1.241449e-13 3.480668e-12 6 73518698 73518848 151 - 4.595 4.623 0.092
ENSG00000156508 E018 4.339796e+01 1.528159e-02 5.840690e-01 7.080702e-01 6 73518849 73518931 83 - 1.654 1.604 -0.169
ENSG00000156508 E019 4.458755e+04 9.701284e-05 2.493322e-03 8.744352e-03 6 73518932 73519228 297 - 4.644 4.628 -0.053
ENSG00000156508 E020 6.102322e+01 1.341415e-02 3.696523e-01 5.140498e-01 6 73519229 73519336 108 - 1.809 1.733 -0.259
ENSG00000156508 E021 3.170406e+04 3.643375e-04 4.506335e-11 8.426388e-10 6 73519337 73519409 73 - 4.513 4.447 -0.218
ENSG00000156508 E022 3.586290e+04 4.630525e-04 3.652941e-15 1.281791e-13 6 73519410 73519507 98 - 4.573 4.487 -0.287
ENSG00000156508 E023 2.701308e+04 3.197205e-04 5.022280e-27 6.490150e-25 6 73519508 73519516 9 - 4.455 4.355 -0.331
ENSG00000156508 E024 5.210275e+01 3.763047e-02 7.084341e-01 8.060801e-01 6 73519517 73519882 366 - 1.736 1.669 -0.227
ENSG00000156508 E025 2.687996e+04 3.700987e-04 1.622221e-24 1.695118e-22 6 73519883 73519891 9 - 4.453 4.352 -0.338
ENSG00000156508 E026 2.845956e+04 5.717852e-04 1.757283e-15 6.434324e-14 6 73519892 73520056 165 - 4.477 4.378 -0.330
ENSG00000156508 E027 4.461384e+01 6.095398e-04 6.761844e-01 7.812282e-01 6 73520057 73520150 94 - 1.637 1.674 0.124
ENSG00000156508 E028 3.682645e+01 2.911215e-02 2.265903e-01 3.583359e-01 6 73520151 73520361 211 - 1.522 1.626 0.356
ENSG00000156508 E029 4.269443e+01 3.436912e-02 4.714907e-01 6.105977e-01 6 73520362 73520909 548 - 1.663 1.561 -0.348
ENSG00000156508 E030 1.377998e+01 3.115118e-02 1.160569e-01 2.143240e-01 6 73520910 73520999 90 - 1.224 1.008 -0.779
ENSG00000156508 E031 8.784328e+03 2.438787e-03 8.319189e-06 5.629940e-05 6 73521000 73521506 507 - 3.974 3.851 -0.409
ENSG00000156508 E032 1.587244e+01 2.343794e-02 2.562420e-01 3.932148e-01 6 73521507 73521731 225 - 1.166 1.294 0.451
ENSG00000156508 E033 3.976237e+00 1.711557e-02 5.607185e-01 6.886819e-01 6 73521732 73521900 169 - 0.651 0.746 0.397
ENSG00000156508 E034 1.560506e+01 1.359855e-02 4.331802e-01 5.756147e-01 6 73523447 73523724 278 - 1.179 1.263 0.296
ENSG00000156508 E035 1.140136e+01 1.503629e-03 1.611688e-01 2.766241e-01 6 73523725 73523837 113 - 1.030 1.181 0.543
ENSG00000156508 E036 1.211529e+00 1.025712e-02 5.717670e-01 6.980027e-01 6 73525477 73525587 111 - 0.378 0.282 -0.603