ENSG00000156500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414371 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding protein_coding 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.2674870 0.37318262 0.50704218 0.062835294 0.07733809 0.43224985 0.13347083 0.19013333 0.22296667 0.032833333 0.797933440 2.8147e-05 FALSE FALSE
ENST00000475361 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding protein_coding 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.2666352 0.43391741 0.21855176 0.216962479 0.21855176 -0.95777034 0.16603750 0.25186667 0.10083333 -0.151033333 0.578928921 2.8147e-05   FALSE
ENST00000482240 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding protein_coding 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.2645736 0.33368876 0.27154227 0.333688764 0.27154227 -0.28775116 0.13541250 0.13363333 0.13160000 -0.002033333 0.972455474 2.8147e-05   FALSE
ENST00000642481 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding nonsense_mediated_decay 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.1581368 0.18365194 0.06581253 0.103206431 0.06581253 -1.35295784 0.07607083 0.08366667 0.02603333 -0.057633333 0.558183254 2.8147e-05 FALSE TRUE
ENST00000644752 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding nonsense_mediated_decay 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.1552860 0.24114973 0.09047986 0.021588734 0.09047986 -1.32164134 0.08460417 0.12596667 0.04383333 -0.082133333 0.282625332 2.8147e-05 FALSE FALSE
ENST00000645176 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding nonsense_mediated_decay 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.1034766 0.07074763 0.07234456 0.006788658 0.07234456 0.02825341 0.06080833 0.03720000 0.03336667 -0.003833333 0.732864405 2.8147e-05 FALSE FALSE
ENST00000647516 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding protein_coding 1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.2066360 0.00000000 0.72020039 0.000000000 0.28177158 6.19022054 0.09836250 0.00000000 0.30703333 0.307033333 0.000028147 2.8147e-05 FALSE TRUE
MSTRG.34923.4 ENSG00000156500 HEK293_OSMI2_2hA HEK293_TMG_2hB PABIR3 protein_coding   1.888787 1.982852 2.253125 0.2600853 0.1410552 0.1834816 0.1085855 0.17946066 0.11580100 0.139985825 0.06272502 -0.59075489 0.06312083 0.10270000 0.05510000 -0.047600000 0.969718935 2.8147e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156500 E001 0.5911862 0.018278675 0.0283434660 0.068691995 X 134796395 134796408 14 + 0.381 0.000 -12.304
ENSG00000156500 E002 1.0330470 0.012169455 0.0023130181 0.008191467 X 134796409 134796447 39 + 0.539 0.000 -15.437
ENSG00000156500 E003 0.7490443 0.108143573 0.0190972673 0.049551552 X 134796448 134796460 13 + 0.441 0.000 -14.968
ENSG00000156500 E004 0.8889184 0.013696863 0.0662731281 0.137176816 X 134796461 134796788 328 + 0.440 0.114 -2.545
ENSG00000156500 E005 4.7963280 0.024339851 0.4348535551 0.577116867 X 134796789 134796864 76 + 0.821 0.693 -0.516
ENSG00000156500 E006 4.1997321 0.004045682 0.2720734410 0.410908155 X 134804101 134804115 15 + 0.797 0.635 -0.669
ENSG00000156500 E007 9.1725556 0.038568717 0.1300002074 0.234172436 X 134804116 134804246 131 + 1.112 0.887 -0.831
ENSG00000156500 E008 0.6579068 0.406357782 0.9572731721 0.977214966 X 134807169 134807190 22 + 0.231 0.206 -0.209
ENSG00000156500 E009 0.6579068 0.406357782 0.9572731721 0.977214966 X 134807191 134807192 2 + 0.231 0.206 -0.209
ENSG00000156500 E010 0.6579068 0.406357782 0.9572731721 0.977214966 X 134807193 134807193 1 + 0.231 0.206 -0.209
ENSG00000156500 E011 0.9544932 0.021102380 0.5114489480 0.646479906 X 134807194 134807216 23 + 0.231 0.343 0.776
ENSG00000156500 E012 1.5059359 0.009817677 0.1295009263 0.233461247 X 134807217 134807222 6 + 0.231 0.493 1.585
ENSG00000156500 E013 2.0176379 0.015498639 0.0312302808 0.074348311 X 134807223 134807236 14 + 0.231 0.603 2.098
ENSG00000156500 E014 1.9874489 0.007702206 0.1234202542 0.224828176 X 134807237 134807238 2 + 0.313 0.569 1.362
ENSG00000156500 E015 2.5839456 0.006025898 0.4591028568 0.599335808 X 134807239 134807252 14 + 0.493 0.603 0.514
ENSG00000156500 E016 3.6826665 0.004557949 0.3230680641 0.466403575 X 134807253 134807258 6 + 0.581 0.718 0.586
ENSG00000156500 E017 3.6492553 0.004469034 0.3244093986 0.467762561 X 134807259 134807260 2 + 0.581 0.717 0.585
ENSG00000156500 E018 4.2425298 0.003885646 0.3948424721 0.538672806 X 134807261 134807280 20 + 0.655 0.765 0.455
ENSG00000156500 E019 5.7110167 0.003563199 0.4211534305 0.564279292 X 134807281 134807341 61 + 0.772 0.865 0.362
ENSG00000156500 E020 7.3026123 0.108533710 0.3317011334 0.475342360 X 134807342 134807539 198 + 0.820 0.966 0.556
ENSG00000156500 E021 20.0752994 0.001055777 0.3589999657 0.503337501 X 134807540 134807708 169 + 1.364 1.287 -0.269
ENSG00000156500 E022 0.5503986 0.022001725 0.6371365393 0.751083382 X 134808105 134808180 76 + 0.131 0.205 0.781
ENSG00000156500 E023 51.9827429 0.001649378 0.0003541157 0.001596111 X 134809187 134811183 1997 + 1.813 1.649 -0.553
ENSG00000156500 E024 6.7824682 0.002638793 0.2570666323 0.394106289 X 134814771 134814849 79 + 0.821 0.946 0.477
ENSG00000156500 E025 21.2277547 0.005059488 0.6168090188 0.734769628 X 134821327 134822990 1664 + 1.337 1.365 0.096
ENSG00000156500 E026 3.6010068 0.009238116 0.0675255197 0.139238173 X 134829226 134829282 57 + 0.493 0.764 1.190
ENSG00000156500 E027 0.3268771 0.028918704 0.9330973803   X 134831636 134831668 33 + 0.131 0.114 -0.221
ENSG00000156500 E028 2.6465016 0.030152955 0.4782050545 0.616645768 X 134832945 134833128 184 + 0.493 0.603 0.514
ENSG00000156500 E029 0.2214452 0.050363763 0.5336628391   X 134834074 134834226 153 + 0.000 0.115 12.033
ENSG00000156500 E030 0.7393776 0.339480923 0.8918385160 0.934922077 X 134835095 134835674 580 + 0.231 0.271 0.300
ENSG00000156500 E031 0.1482932 0.041159753 0.5390714433   X 134835675 134835796 122 + 0.000 0.114 12.039
ENSG00000156500 E032 5.7181870 0.003260997 0.0108902285 0.030904478 X 134838727 134839172 446 + 0.619 0.946 1.306
ENSG00000156500 E033 4.5390885 0.004928959 0.0709006271 0.144835626 X 134839173 134839477 305 + 0.581 0.828 1.025
ENSG00000156500 E034 1.8371535 0.135758703 0.3137963628 0.456426912 X 134839478 134839561 84 + 0.312 0.501 1.041
ENSG00000156500 E035 1.2888312 0.190197284 0.3497662340 0.493961120 X 134839562 134839603 42 + 0.231 0.406 1.138
ENSG00000156500 E036 2.1129269 0.044506284 0.1143834559 0.211938017 X 134844110 134844193 84 + 0.313 0.600 1.500
ENSG00000156500 E037 0.7362571 0.019481276 0.5562535399 0.684930457 X 134845205 134845248 44 + 0.313 0.204 -0.810
ENSG00000156500 E038 0.8073328 0.015556714 0.5609063157 0.688817761 X 134845347 134845401 55 + 0.313 0.205 -0.806
ENSG00000156500 E039 0.6664265 0.018040781 0.8999086805 0.940145097 X 134847383 134847475 93 + 0.231 0.205 -0.221
ENSG00000156500 E040 0.4438354 0.038024528 0.6545117264 0.764667549 X 134847883 134847885 3 + 0.131 0.204 0.772
ENSG00000156500 E041 0.4438354 0.038024528 0.6545117264 0.764667549 X 134847886 134847971 86 + 0.131 0.204 0.772
ENSG00000156500 E042 0.1482932 0.041159753 0.5390714433   X 134849167 134849228 62 + 0.000 0.114 12.039
ENSG00000156500 E043 1.1102619 0.012480003 0.8397412468 0.899896439 X 134852800 134852896 97 + 0.313 0.343 0.191
ENSG00000156500 E044 2.9277484 0.043563160 0.5739633362 0.699867617 X 134854091 134854835 745 + 0.539 0.633 0.419