ENSG00000156469

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287025 ENSG00000156469 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF3 protein_coding protein_coding 22.86766 12.54468 31.37324 1.13828 0.7539262 1.32177 18.378129 9.9147027 26.3216261 1.0869742 1.42418129 1.407701 0.79178333 0.7874 0.83776667 0.05036667 4.851158e-01 3.703855e-05 FALSE  
ENST00000522822 ENSG00000156469 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF3 protein_coding protein_coding 22.86766 12.54468 31.37324 1.13828 0.7539262 1.32177 1.786805 0.4065453 2.4878653 0.1554275 0.56510173 2.584150 0.08549167 0.0307 0.08006667 0.04936667 1.703665e-01 3.703855e-05 FALSE  
MSTRG.31857.3 ENSG00000156469 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF3 protein_coding   22.86766 12.54468 31.37324 1.13828 0.7539262 1.32177 1.078223 1.2606726 0.5525483 0.3310726 0.09500965 -1.175543 0.05419583 0.0996 0.01763333 -0.08196667 3.703855e-05 3.703855e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156469 E001 0.0000000       8 96239398 96239401 4 -      
ENSG00000156469 E002 0.0000000       8 96239402 96239416 15 -      
ENSG00000156469 E003 0.8449086 0.0144396274 0.0325781022 0.076960206 8 96239417 96239423 7 - 0.089 0.455 3.018
ENSG00000156469 E004 0.8449086 0.0144396274 0.0325781022 0.076960206 8 96239424 96239428 5 - 0.089 0.455 3.018
ENSG00000156469 E005 15.8737752 0.0098557042 0.3213036984 0.464537395 8 96239429 96239495 67 - 1.181 1.270 0.315
ENSG00000156469 E006 150.9622340 0.0002279869 0.0055181620 0.017334338 8 96239496 96239685 190 - 2.140 2.218 0.260
ENSG00000156469 E007 1.2200474 0.0138868702 0.5835210338 0.707621797 8 96239794 96239855 62 - 0.282 0.379 0.610
ENSG00000156469 E008 187.5142837 0.0002986400 0.0040690567 0.013335477 8 96243919 96244080 162 - 2.236 2.308 0.243
ENSG00000156469 E009 131.2863167 0.0002579452 0.0054778028 0.017229268 8 96245860 96245931 72 - 2.075 2.159 0.282
ENSG00000156469 E010 150.6622308 0.0011331245 0.6292091103 0.744629492 8 96246307 96246454 148 - 2.164 2.177 0.046
ENSG00000156469 E011 189.8315481 0.0002524658 0.5911952215 0.713993052 8 96250906 96251095 190 - 2.265 2.277 0.041
ENSG00000156469 E012 174.2786122 0.0002547164 0.8555447432 0.910676516 8 96256962 96257114 153 - 2.234 2.227 -0.022
ENSG00000156469 E013 9.3275555 0.0268366709 0.0068569276 0.020853456 8 96257115 96257275 161 - 1.110 0.714 -1.509
ENSG00000156469 E014 148.3604041 0.0002232136 0.0039990487 0.013139682 8 96258357 96258487 131 - 2.191 2.104 -0.292
ENSG00000156469 E015 87.2837349 0.0003833351 0.2072637760 0.335230091 8 96258488 96258525 38 - 1.950 1.900 -0.170
ENSG00000156469 E016 151.9684837 0.0017613616 0.0062926772 0.019381057 8 96258526 96258700 175 - 2.203 2.105 -0.328
ENSG00000156469 E017 10.8223974 0.0016277401 0.0003314488 0.001506595 8 96260137 96260247 111 - 1.174 0.751 -1.587
ENSG00000156469 E018 72.1235402 0.0004260657 0.0226863602 0.057105350 8 96261501 96261610 110 - 1.883 1.781 -0.344