ENSG00000156345

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325303 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding protein_coding 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 1.6347502 3.0469448 0.9464483 0.08049857 0.20798043 -1.67633157 0.20600417 0.28510000 0.1904000 -0.09470000 0.251638614 0.002827629 FALSE  
ENST00000375871 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding protein_coding 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 1.2704568 2.0302327 1.0354725 0.33743873 0.18396738 -0.96457857 0.16186250 0.19036667 0.2042667 0.01390000 0.921045565 0.002827629 FALSE  
ENST00000375883 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding protein_coding 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 2.1008986 2.9534848 0.7629355 0.19299478 0.29337175 -1.93887475 0.25259167 0.27763333 0.1575667 -0.12006667 0.434201387 0.002827629 FALSE  
ENST00000459720 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding retained_intron 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 1.4080922 0.9190485 0.8747762 0.05609776 0.03898202 -0.07044127 0.19638750 0.08643333 0.1757333 0.08930000 0.002827629 0.002827629 TRUE  
ENST00000486228 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding retained_intron 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 0.2869469 0.1494925 0.6324124 0.09471374 0.46410096 2.01001155 0.03970417 0.01353333 0.1185667 0.10503333 0.611044803 0.002827629 TRUE  
ENST00000603475 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding retained_intron 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 0.5279405 0.3086015 0.3720898 0.04221695 0.02690958 0.26215884 0.07022917 0.02866667 0.0745000 0.04583333 0.008594437 0.002827629 FALSE  
ENST00000605159 ENSG00000156345 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK20 protein_coding protein_coding 7.811664 10.6947 4.995454 0.3839946 0.341066 -1.096672 0.4222211 0.9449069 0.2100477 0.42314141 0.21004771 -2.11754369 0.05136250 0.08653333 0.0487000 -0.03783333 0.416501588 0.002827629 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156345 E001 2.295879 0.0113042051 3.257999e-01 4.692387e-01 9 87966441 87966445 5 - 0.598 0.434 -0.785
ENSG00000156345 E002 2.592465 0.0379170956 5.529962e-01 6.822181e-01 9 87966446 87966449 4 - 0.598 0.496 -0.471
ENSG00000156345 E003 14.078229 0.0015605175 9.487416e-01 9.718783e-01 9 87966450 87966610 161 - 1.125 1.122 -0.009
ENSG00000156345 E004 83.579640 0.0188026841 8.767340e-02 1.715960e-01 9 87966611 87966881 271 - 1.772 1.906 0.450
ENSG00000156345 E005 146.632554 0.0004005155 1.633135e-05 1.033513e-04 9 87966882 87967226 345 - 2.003 2.148 0.486
ENSG00000156345 E006 167.273294 0.0003350940 1.743685e-01 2.938617e-01 9 87967227 87967631 405 - 2.137 2.180 0.145
ENSG00000156345 E007 43.329807 0.0007825933 2.794485e-01 4.192026e-01 9 87967632 87967659 28 - 1.544 1.612 0.232
ENSG00000156345 E008 20.591053 0.0010213500 1.217368e-07 1.216707e-06 9 87967660 87969193 1534 - 1.526 1.129 -1.384
ENSG00000156345 E009 68.893893 0.0042751933 2.098767e-01 3.384047e-01 9 87969194 87969349 156 - 1.734 1.807 0.246
ENSG00000156345 E010 18.928670 0.0039127094 2.827775e-02 6.855641e-02 9 87969350 87969795 446 - 1.365 1.182 -0.641
ENSG00000156345 E011 48.961986 0.0004911659 1.508654e-01 2.628501e-01 9 87969796 87969919 124 - 1.579 1.664 0.287
ENSG00000156345 E012 27.960050 0.0008144187 1.257036e-06 1.022155e-05 9 87969920 87970439 520 - 1.617 1.304 -1.080
ENSG00000156345 E013 10.344545 0.0019542490 2.006541e-05 1.244164e-04 9 87970440 87970567 128 - 1.273 0.846 -1.561
ENSG00000156345 E014 24.216450 0.0007790071 1.269971e-01 2.299612e-01 9 87970568 87970630 63 - 1.425 1.317 -0.375
ENSG00000156345 E015 15.974502 0.0194289555 2.932499e-03 1.006491e-02 9 87970631 87970775 145 - 1.383 1.071 -1.104
ENSG00000156345 E016 30.486607 0.0009584265 1.493008e-01 2.607164e-01 9 87970776 87970786 11 - 1.513 1.421 -0.316
ENSG00000156345 E017 64.994188 0.0004544477 2.739595e-01 4.130616e-01 9 87970787 87970897 111 - 1.797 1.750 -0.158
ENSG00000156345 E018 3.943843 0.0445294118 1.560244e-02 4.185134e-02 9 87970898 87971036 139 - 0.898 0.500 -1.675
ENSG00000156345 E019 3.547023 0.0151345194 2.119404e-03 7.594523e-03 9 87971037 87971146 110 - 0.898 0.435 -2.004
ENSG00000156345 E020 84.946535 0.0003251645 7.253950e-01 8.186723e-01 9 87971147 87971335 189 - 1.886 1.876 -0.034
ENSG00000156345 E021 73.768426 0.0004212325 1.128426e-02 3.184047e-02 9 87973922 87974035 114 - 1.726 1.848 0.409
ENSG00000156345 E022 2.204741 0.0068452733 5.729995e-01 6.990158e-01 9 87974036 87974074 39 - 0.394 0.498 0.538
ENSG00000156345 E023 1.391055 0.1090063551 4.183885e-01 5.616590e-01 9 87974075 87974371 297 - 0.472 0.314 -0.894
ENSG00000156345 E024 76.601052 0.0003375683 6.751867e-01 7.805253e-01 9 87974372 87974753 382 - 1.845 1.831 -0.047