ENSG00000156313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476559 ENSG00000156313 HEK293_OSMI2_2hA HEK293_TMG_2hB RPGR protein_coding retained_intron 4.575551 1.603193 7.853528 0.02188073 0.3305265 2.285257 0.2122045 0.1769131 0.1857603 0.0921004 0.09690559 0.06672068 0.07993333 0.1090000 0.0246000 -0.0844000 0.59011103 0.04900869   FALSE
ENST00000494707 ENSG00000156313 HEK293_OSMI2_2hA HEK293_TMG_2hB RPGR protein_coding protein_coding 4.575551 1.603193 7.853528 0.02188073 0.3305265 2.285257 0.2462928 0.0000000 1.1111802 0.0000000 0.58186096 6.80887432 0.03532083 0.0000000 0.1365667 0.1365667 0.39007940 0.04900869 FALSE TRUE
ENST00000642395 ENSG00000156313 HEK293_OSMI2_2hA HEK293_TMG_2hB RPGR protein_coding protein_coding 4.575551 1.603193 7.853528 0.02188073 0.3305265 2.285257 0.4204725 0.4871756 0.0000000 0.2670485 0.00000000 -5.63568366 0.12630000 0.2997000 0.0000000 -0.2997000 0.04900869 0.04900869 FALSE TRUE
ENST00000644337 ENSG00000156313 HEK293_OSMI2_2hA HEK293_TMG_2hB RPGR protein_coding protein_coding 4.575551 1.603193 7.853528 0.02188073 0.3305265 2.285257 1.4706335 0.2039400 3.5354580 0.2039400 0.44067160 4.05069416 0.28425417 0.1298333 0.4473000 0.3174667 0.14198976 0.04900869 FALSE TRUE
MSTRG.34095.3 ENSG00000156313 HEK293_OSMI2_2hA HEK293_TMG_2hB RPGR protein_coding   4.575551 1.603193 7.853528 0.02188073 0.3305265 2.285257 1.1500741 0.5640831 1.8528713 0.1283905 0.16138362 1.69819645 0.22835000 0.3540333 0.2372000 -0.1168333 0.49775861 0.04900869 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156313 E001 0.0000000       X 38269163 38269170 8 -      
ENSG00000156313 E002 0.2214452 0.0380768349 1.112517e-01   X 38269171 38269342 172 - 0.000 0.218 13.374
ENSG00000156313 E003 0.2214452 0.0380768349 1.112517e-01   X 38269343 38269348 6 - 0.000 0.218 13.389
ENSG00000156313 E004 3.3829320 0.0366055066 2.190963e-04 1.045651e-03 X 38269349 38269401 53 - 0.331 0.948 2.787
ENSG00000156313 E005 4.4189952 0.0062798698 5.593547e-08 5.963313e-07 X 38269402 38269413 12 - 0.331 1.104 3.357
ENSG00000156313 E006 5.6033515 0.0183146982 1.037466e-10 1.825945e-09 X 38269414 38269496 83 - 0.331 1.237 3.831
ENSG00000156313 E007 3.0194335 0.0092383115 8.369846e-08 8.629477e-07 X 38269497 38269519 23 - 0.173 1.004 4.215
ENSG00000156313 E008 2.7572033 0.0054598672 3.690736e-06 2.708918e-05 X 38269520 38269526 7 - 0.218 0.944 3.577
ENSG00000156313 E009 28.0773454 0.0129489003 1.250991e-03 4.813282e-03 X 38269527 38269832 306 - 1.310 1.599 0.995
ENSG00000156313 E010 0.2924217 0.0290785164 1.000000e+00   X 38272311 38272589 279 - 0.123 0.000 -10.677
ENSG00000156313 E011 20.0863266 0.0618084739 7.769908e-01 8.564300e-01 X 38273386 38273429 44 - 1.263 1.254 -0.031
ENSG00000156313 E012 19.9909994 0.0011568235 6.452703e-01 7.574104e-01 X 38273430 38273477 48 - 1.266 1.236 -0.107
ENSG00000156313 E013 3.2641533 0.1781998279 2.931139e-01 4.341507e-01 X 38273478 38273942 465 - 0.495 0.749 1.117
ENSG00000156313 E014 24.5573265 0.0010342858 7.143521e-01 8.105937e-01 X 38275089 38275146 58 - 1.343 1.325 -0.066
ENSG00000156313 E015 45.6234134 0.0010747027 4.299023e-02 9.652472e-02 X 38276587 38276772 186 - 1.561 1.691 0.440
ENSG00000156313 E016 0.2966881 0.0290785164 1.000000e+00   X 38279167 38279205 39 - 0.123 0.000 -10.677
ENSG00000156313 E017 4.4425104 0.0316162307 7.125192e-02 1.454137e-01 X 38284408 38287093 2686 - 0.577 0.877 1.234
ENSG00000156313 E018 29.5411690 0.0246945791 6.412284e-01 7.543065e-01 X 38287094 38287245 152 - 1.420 1.379 -0.141
ENSG00000156313 E019 1.8414370 0.0075422453 7.098548e-01 8.071246e-01 X 38287246 38287860 615 - 0.392 0.469 0.406
ENSG00000156313 E020 9.5638438 0.0018456211 1.390032e-03 5.273920e-03 X 38287861 38287864 4 - 1.033 0.556 -1.915
ENSG00000156313 E021 30.7647334 0.0059007538 1.452514e-02 3.942207e-02 X 38287865 38288041 177 - 1.473 1.268 -0.712
ENSG00000156313 E022 28.0123249 0.0007500175 2.977809e-01 4.391367e-01 X 38290959 38291024 66 - 1.409 1.338 -0.247
ENSG00000156313 E023 27.6199218 0.0008797153 4.609308e-01 6.009149e-01 X 38291393 38291484 92 - 1.398 1.351 -0.164
ENSG00000156313 E024 0.0000000       X 38295985 38296144 160 -      
ENSG00000156313 E025 17.8588127 0.0011259850 2.377520e-01 3.715460e-01 X 38297284 38297307 24 - 1.230 1.125 -0.375
ENSG00000156313 E026 28.3184486 0.0007363540 4.852432e-01 6.231511e-01 X 38297308 38297452 145 - 1.406 1.363 -0.150
ENSG00000156313 E027 0.1515154 0.0427259206 1.000000e+00   X 38298331 38298447 117 - 0.066 0.000 -9.678
ENSG00000156313 E028 14.8496087 0.0013037966 5.287214e-01 6.616159e-01 X 38298956 38298969 14 - 1.111 1.184 0.262
ENSG00000156313 E029 27.4934960 0.0007067421 6.337316e-01 7.483501e-01 X 38298970 38299141 172 - 1.389 1.363 -0.091
ENSG00000156313 E030 25.6339899 0.0008288160 3.004875e-01 4.421781e-01 X 38301247 38301371 125 - 1.371 1.297 -0.259
ENSG00000156313 E031 0.0000000       X 38302613 38302672 60 -      
ENSG00000156313 E032 0.0000000       X 38303601 38303814 214 -      
ENSG00000156313 E033 19.8078586 0.0009519319 2.971544e-01 4.384620e-01 X 38304635 38304699 65 - 1.270 1.184 -0.304
ENSG00000156313 E034 23.4639538 0.0008135247 1.865043e-01 3.093550e-01 X 38304700 38304790 91 - 1.340 1.236 -0.364
ENSG00000156313 E035 0.0000000       X 38304791 38304831 41 -      
ENSG00000156313 E036 31.9982958 0.0034183533 3.141775e-01 4.568656e-01 X 38310615 38310773 159 - 1.464 1.398 -0.227
ENSG00000156313 E037 0.2998086 0.0297372708 3.253841e-01   X 38317246 38317315 70 - 0.066 0.217 1.989
ENSG00000156313 E038 33.3180988 0.0006489892 3.382980e-01 4.821590e-01 X 38317316 38317465 150 - 1.478 1.420 -0.199
ENSG00000156313 E039 0.0000000       X 38317811 38317893 83 -      
ENSG00000156313 E040 38.1463779 0.0005939748 5.756308e-01 7.011878e-01 X 38318829 38318987 159 - 1.525 1.498 -0.090
ENSG00000156313 E041 0.0000000       X 38318988 38318990 3 -      
ENSG00000156313 E042 29.0196987 0.0006676807 3.763011e-01 5.206310e-01 X 38321027 38321089 63 - 1.420 1.363 -0.197
ENSG00000156313 E043 30.2784819 0.0096514610 6.901566e-02 1.417416e-01 X 38322853 38322945 93 - 1.456 1.298 -0.546
ENSG00000156313 E044 27.3908121 0.0008682437 6.074491e-02 1.278788e-01 X 38323399 38323524 126 - 1.412 1.268 -0.501
ENSG00000156313 E045 0.1451727 0.0423789505 1.000000e+00   X 38325773 38325935 163 - 0.066 0.000 -9.677
ENSG00000156313 E046 0.0000000       X 38326678 38326952 275 -      
ENSG00000156313 E047 17.0066614 0.0011174900 5.369845e-01 6.686479e-01 X 38327340 38327586 247 - 1.168 1.236 0.243