ENSG00000156304

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286835 ENSG00000156304 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF4 protein_coding protein_coding 37.06181 39.91675 37.61163 2.543285 0.2929947 -0.08579324 17.2904156 23.736976 13.097547 2.4119068 0.5673213 -0.8573461 0.45949167 0.59220000 0.34816667 -0.24403333 7.440246e-07 6.504806e-22 FALSE TRUE
ENST00000399804 ENSG00000156304 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF4 protein_coding protein_coding 37.06181 39.91675 37.61163 2.543285 0.2929947 -0.08579324 10.7450507 10.633868 11.767858 0.7821451 0.5692704 0.1460547 0.29029167 0.26653333 0.31270000 0.04616667 2.571752e-01 6.504806e-22 FALSE TRUE
ENST00000434667 ENSG00000156304 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF4 protein_coding protein_coding 37.06181 39.91675 37.61163 2.543285 0.2929947 -0.08579324 3.7627610 2.902458 5.524199 1.4568043 1.4455782 0.9261372 0.10495000 0.07563333 0.14726667 0.07163333 7.137570e-01 6.504806e-22 FALSE TRUE
MSTRG.21223.6 ENSG00000156304 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF4 protein_coding   37.06181 39.91675 37.61163 2.543285 0.2929947 -0.08579324 0.6538395 0.000000 2.435937 0.0000000 0.3263122 7.9342432 0.01749167 0.00000000 0.06466667 0.06466667 6.504806e-22 6.504806e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156304 E001 7.547875 0.0957496619 8.631292e-02 1.695024e-01 21 31671000 31671032 33 - 1.092 0.769 -1.223
ENSG00000156304 E002 144.228767 0.0002667110 3.303165e-30 5.657999e-28 21 31671033 31671227 195 - 1.871 2.266 1.323
ENSG00000156304 E003 122.760559 0.0016843358 8.957914e-13 2.217496e-11 21 31671228 31671241 14 - 1.880 2.177 0.996
ENSG00000156304 E004 609.858464 0.0021714117 2.962145e-22 2.428254e-20 21 31671242 31671497 256 - 2.589 2.863 0.914
ENSG00000156304 E005 272.262134 0.0044963951 1.621277e-10 2.760864e-09 21 31671498 31671505 8 - 2.242 2.513 0.902
ENSG00000156304 E006 422.634825 0.0044942034 3.352763e-10 5.409393e-09 21 31671506 31671576 71 - 2.450 2.698 0.827
ENSG00000156304 E007 594.303343 0.0048990149 1.259626e-09 1.831408e-08 21 31671577 31671721 145 - 2.605 2.842 0.791
ENSG00000156304 E008 987.539318 0.0040079015 9.310227e-06 6.232049e-05 21 31671722 31672354 633 - 2.885 3.038 0.508
ENSG00000156304 E009 25.165828 0.0007728679 2.526842e-04 1.186523e-03 21 31683995 31685048 1054 - 1.534 1.294 -0.829
ENSG00000156304 E010 321.548714 0.0004516765 1.269022e-01 2.298332e-01 21 31685049 31685174 126 - 2.468 2.514 0.153
ENSG00000156304 E011 197.198845 0.0002153479 1.518016e-01 2.641143e-01 21 31685175 31685240 66 - 2.252 2.301 0.165
ENSG00000156304 E012 311.931886 0.0002297102 6.973587e-01 7.974919e-01 21 31685398 31685484 87 - 2.469 2.489 0.067
ENSG00000156304 E013 408.732349 0.0002291129 3.420990e-01 4.860953e-01 21 31685568 31685733 166 - 2.581 2.611 0.099
ENSG00000156304 E014 400.982360 0.0001487408 1.391347e-02 3.802954e-02 21 31688307 31688464 158 - 2.554 2.612 0.192
ENSG00000156304 E015 227.866249 0.0002116016 4.506612e-01 5.917377e-01 21 31690797 31690820 24 - 2.327 2.357 0.101
ENSG00000156304 E016 386.560617 0.0001578606 3.455685e-02 8.081935e-02 21 31690821 31690953 133 - 2.592 2.565 -0.092
ENSG00000156304 E017 341.639218 0.0001797282 3.834290e-05 2.220101e-04 21 31691817 31691930 114 - 2.563 2.493 -0.233
ENSG00000156304 E018 12.899385 0.0152321222 3.494452e-08 3.883483e-07 21 31691931 31692348 418 - 1.398 0.790 -2.214
ENSG00000156304 E019 314.521639 0.0015376136 8.284165e-06 5.608241e-05 21 31692349 31692442 94 - 2.548 2.440 -0.358
ENSG00000156304 E020 190.850902 0.0027839713 5.342824e-05 2.988961e-04 21 31692443 31692449 7 - 2.344 2.213 -0.438
ENSG00000156304 E021 421.419407 0.0062530979 5.557746e-03 1.743960e-02 21 31693294 31693484 191 - 2.669 2.574 -0.316
ENSG00000156304 E022 137.265322 0.0029340529 1.158895e-01 2.140769e-01 21 31694204 31694215 12 - 2.154 2.105 -0.163
ENSG00000156304 E023 270.653130 0.0032720313 6.209309e-02 1.301587e-01 21 31694216 31694289 74 - 2.449 2.400 -0.165
ENSG00000156304 E024 359.281810 0.0010646498 1.385292e-05 8.905909e-05 21 31694813 31694980 168 - 2.596 2.505 -0.304
ENSG00000156304 E025 249.222046 0.0004138961 1.144528e-04 5.882938e-04 21 31696113 31696221 109 - 2.433 2.352 -0.271
ENSG00000156304 E026 255.003962 0.0010821651 8.678220e-06 5.847844e-05 21 31696569 31696736 168 - 2.457 2.349 -0.359
ENSG00000156304 E027 114.522293 0.0003070113 5.505171e-04 2.348743e-03 21 31696737 31696747 11 - 2.109 2.004 -0.351
ENSG00000156304 E028 98.560678 0.0020099456 8.683173e-03 2.549329e-02 21 31696748 31696750 3 - 2.042 1.945 -0.324
ENSG00000156304 E029 1.190803 0.0156163735 7.221939e-02 1.470318e-01 21 31700759 31700994 236 - 0.507 0.197 -1.948
ENSG00000156304 E030 319.242161 0.0025353735 2.686415e-06 2.032725e-05 21 31700995 31701171 177 - 2.569 2.437 -0.438
ENSG00000156304 E031 293.431600 0.0054181148 6.347104e-05 3.484525e-04 21 31701776 31701918 143 - 2.540 2.394 -0.488
ENSG00000156304 E032 241.818503 0.0105417692 8.515495e-04 3.443258e-03 21 31702244 31702379 136 - 2.465 2.302 -0.545
ENSG00000156304 E033 231.897544 0.0077131502 1.143960e-06 9.381403e-06 21 31703765 31703926 162 - 2.474 2.257 -0.724
ENSG00000156304 E034 107.135811 0.0119364249 6.159391e-07 5.353144e-06 21 31705423 31705467 45 - 2.176 1.879 -0.998
ENSG00000156304 E035 119.554414 0.0022822687 7.789291e-21 5.520605e-19 21 31706274 31706357 84 - 2.249 1.889 -1.204
ENSG00000156304 E036 194.604486 0.0085500427 5.459442e-15 1.867934e-13 21 31731663 31732118 456 - 2.472 2.085 -1.293