ENSG00000156299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286827 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding protein_coding 12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 2.6352824 0.8825089 5.6400865 0.44402830 0.80255036 2.6623345 0.20571250 0.065533333 0.38636667 0.32083333 1.209455e-01 3.950337e-35 FALSE TRUE
ENST00000491927 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding retained_intron 12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 1.1517252 0.9334775 1.2232448 0.09997341 0.21263551 0.3863992 0.09707500 0.072133333 0.08343333 0.01130000 8.474220e-01 3.950337e-35 FALSE FALSE
ENST00000541036 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding protein_coding 12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 3.5345627 3.9845478 3.4393867 0.59575435 0.99195200 -0.2116923 0.30699167 0.307200000 0.23723333 -0.06996667 6.880240e-01 3.950337e-35 FALSE TRUE
ENST00000636887 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding protein_coding 12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 2.5506310 6.3160024 0.0000000 0.44920426 0.00000000 -9.3051503 0.21272500 0.489966667 0.00000000 -0.48996667 3.950337e-35 3.950337e-35 FALSE TRUE
MSTRG.21214.5 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding   12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 0.3319423 0.0000000 0.9515004 0.00000000 0.50840022 6.5872156 0.02454583 0.000000000 0.06436667 0.06436667 1.974250e-01 3.950337e-35 FALSE TRUE
MSTRG.21214.6 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding   12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 0.8957532 0.4832738 1.8452971 0.10030168 0.20788624 1.9111897 0.07172500 0.036933333 0.12683333 0.08990000 1.084120e-04 3.950337e-35 FALSE TRUE
MSTRG.21214.8 ENSG00000156299 HEK293_OSMI2_2hA HEK293_TMG_2hB TIAM1 protein_coding   12.08439 12.97537 14.58793 0.6277158 0.2640524 0.1688763 0.3401291 0.0469553 0.8363645 0.03035460 0.08436535 3.8933773 0.02634583 0.003766667 0.05716667 0.05340000 1.004759e-08 3.950337e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156299 E001 0.2965864 0.1810821452 1.834979e-01   21 31118416 31118417 2 - 0.000 0.240 10.572
ENSG00000156299 E002 14.1911547 0.0870203808 2.784324e-05 1.668507e-04 21 31118418 31118457 40 - 0.693 1.428 2.713
ENSG00000156299 E003 142.2107321 0.0064720688 5.790009e-21 4.159650e-19 21 31118458 31118670 213 - 1.853 2.352 1.671
ENSG00000156299 E004 164.9537800 0.0031783734 1.271522e-29 2.064147e-27 21 31118671 31118821 151 - 1.935 2.409 1.585
ENSG00000156299 E005 712.1414555 0.0023767276 8.673205e-24 8.408969e-22 21 31118822 31120356 1535 - 2.708 2.972 0.878
ENSG00000156299 E006 67.0854836 0.0106346275 7.090903e-02 1.448497e-01 21 31120357 31120379 23 - 1.759 1.901 0.477
ENSG00000156299 E007 59.9819906 0.0031320987 6.083900e-03 1.883172e-02 21 31120380 31120396 17 - 1.698 1.869 0.578
ENSG00000156299 E008 84.9010664 0.0089308919 8.878208e-02 1.732540e-01 21 31120397 31120449 53 - 1.871 1.999 0.432
ENSG00000156299 E009 84.2271476 0.0090880724 1.980262e-02 5.106667e-02 21 31120450 31120513 64 - 1.846 2.013 0.561
ENSG00000156299 E010 50.9892179 0.0128837325 2.864341e-02 6.929571e-02 21 31120514 31120514 1 - 1.618 1.806 0.639
ENSG00000156299 E011 103.9952645 0.0055118808 3.151077e-01 4.578632e-01 21 31120515 31120642 128 - 1.985 2.060 0.253
ENSG00000156299 E012 98.8840354 0.0057378353 6.790195e-01 7.833143e-01 21 31120643 31120837 195 - 1.997 2.005 0.025
ENSG00000156299 E013 19.9315140 0.0010051977 7.311032e-01 8.228445e-01 21 31123939 31124521 583 - 1.297 1.352 0.190
ENSG00000156299 E014 97.5117552 0.0099900295 2.528307e-01 3.892597e-01 21 31124522 31124694 173 - 1.945 2.046 0.336
ENSG00000156299 E015 69.6406803 0.0046589661 8.585214e-02 1.687479e-01 21 31127065 31127152 88 - 1.791 1.912 0.408
ENSG00000156299 E016 82.6078857 0.0003255547 3.569973e-02 8.300245e-02 21 31130213 31130315 103 - 1.866 1.977 0.372
ENSG00000156299 E017 56.4012878 0.0014864827 1.419354e-01 2.506805e-01 21 31130890 31130948 59 - 1.705 1.806 0.341
ENSG00000156299 E018 87.4449317 0.0019974164 1.670526e-01 2.843682e-01 21 31135933 31136041 109 - 1.959 1.927 -0.107
ENSG00000156299 E019 104.0625540 0.0002771728 2.012479e-03 7.264688e-03 21 31141118 31141236 119 - 2.056 1.977 -0.264
ENSG00000156299 E020 121.8383805 0.0011858031 2.263247e-02 5.698808e-02 21 31141325 31141504 180 - 2.112 2.060 -0.174
ENSG00000156299 E021 87.0125039 0.0074085560 4.815703e-01 6.197861e-01 21 31146895 31147003 109 - 1.948 1.935 -0.043
ENSG00000156299 E022 81.7223212 0.0034615386 2.237767e-01 3.549264e-01 21 31152636 31152761 126 - 1.931 1.902 -0.098
ENSG00000156299 E023 54.5655119 0.0004572687 2.168991e-01 3.466561e-01 21 31153066 31153134 69 - 1.757 1.727 -0.101
ENSG00000156299 E024 86.9116582 0.0010792606 1.105724e-04 5.705154e-04 21 31154247 31154424 178 - 2.002 1.874 -0.430
ENSG00000156299 E025 32.6733701 0.0006391112 1.726545e-04 8.466347e-04 21 31154425 31154426 2 - 1.612 1.406 -0.704
ENSG00000156299 E026 0.0000000       21 31160445 31160909 465 -      
ENSG00000156299 E027 62.1639205 0.0020457298 3.294824e-03 1.113500e-02 21 31164962 31165065 104 - 1.853 1.736 -0.393
ENSG00000156299 E028 83.4043765 0.0009045323 4.803547e-02 1.056968e-01 21 31182421 31182645 225 - 1.951 1.900 -0.171
ENSG00000156299 E029 65.1494521 0.0003765546 3.216201e-04 1.467308e-03 21 31187001 31187087 87 - 1.878 1.748 -0.437
ENSG00000156299 E030 73.1052721 0.0005434129 1.156417e-06 9.474534e-06 21 31195224 31195305 82 - 1.948 1.771 -0.596
ENSG00000156299 E031 73.1358449 0.0088241979 3.821339e-04 1.705598e-03 21 31202908 31203012 105 - 1.951 1.763 -0.633
ENSG00000156299 E032 84.2065419 0.0057360537 1.659263e-04 8.175992e-04 21 31210045 31210215 171 - 2.004 1.832 -0.575
ENSG00000156299 E033 0.2965864 0.1810821452 1.834979e-01   21 31212631 31213397 767 - 0.000 0.240 12.918
ENSG00000156299 E034 55.2054648 0.0063691007 1.076841e-01 2.021185e-01 21 31213398 31213472 75 - 1.778 1.708 -0.239
ENSG00000156299 E035 78.5679974 0.0003699110 3.124698e-03 1.063232e-02 21 31217553 31217699 147 - 1.939 1.850 -0.302
ENSG00000156299 E036 84.9162477 0.0003602245 1.963832e-05 1.220771e-04 21 31223406 31223591 186 - 1.994 1.856 -0.461
ENSG00000156299 E037 101.1290686 0.0002813692 9.632030e-10 1.432644e-08 21 31225726 31225950 225 - 2.090 1.900 -0.638
ENSG00000156299 E038 79.2958892 0.0024935324 1.497202e-07 1.470021e-06 21 31245488 31245660 173 - 1.995 1.777 -0.733
ENSG00000156299 E039 132.7733778 0.0062998735 7.073863e-09 8.968227e-08 21 31251742 31252189 448 - 2.230 1.967 -0.879
ENSG00000156299 E040 238.6383579 0.0074443495 1.101070e-10 1.929107e-09 21 31266010 31266983 974 - 2.488 2.214 -0.912
ENSG00000156299 E041 15.7063616 0.0011157121 6.711198e-04 2.792849e-03 21 31268411 31268695 285 - 1.333 1.063 -0.959
ENSG00000156299 E042 52.4123724 0.0082212186 2.119104e-05 1.306361e-04 21 31276732 31276908 177 - 1.830 1.575 -0.862
ENSG00000156299 E043 56.0466048 0.0200281737 9.985071e-06 6.637469e-05 21 31339243 31339422 180 - 1.885 1.544 -1.156
ENSG00000156299 E044 0.8407440 0.0171867404 8.485354e-01 9.059643e-01 21 31344138 31344261 124 - 0.265 0.244 -0.159
ENSG00000156299 E045 3.3517306 0.0045046280 3.656512e-02 8.464883e-02 21 31461224 31461319 96 - 0.762 0.460 -1.343
ENSG00000156299 E046 15.0672607 0.0900317289 1.248959e-01 2.269807e-01 21 31463916 31463982 67 - 1.290 1.076 -0.763
ENSG00000156299 E047 24.0862575 0.0484894407 7.186291e-05 3.892717e-04 21 31463983 31464035 53 - 1.570 1.075 -1.731
ENSG00000156299 E048 25.4774983 0.0009884342 3.388860e-19 1.974199e-17 21 31558927 31559159 233 - 1.629 0.931 -2.464
ENSG00000156299 E049 0.2924217 0.0271055214 2.715007e-01   21 31559919 31559977 59 - 0.194 0.000 -14.308