ENSG00000156256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399973 ENSG00000156256 HEK293_OSMI2_2hA HEK293_TMG_2hB USP16 protein_coding protein_coding 19.11088 4.444683 35.74847 0.2998952 0.2583606 3.00489 1.2399189 0.0945232 3.134857 0.05114733 0.8723718 4.911099 0.05229167 0.02010000 0.08753333 0.06743333 0.065063537 0.003932936 FALSE FALSE
ENST00000399975 ENSG00000156256 HEK293_OSMI2_2hA HEK293_TMG_2hB USP16 protein_coding protein_coding 19.11088 4.444683 35.74847 0.2998952 0.2583606 3.00489 5.8206945 1.9793004 9.710013 0.28255754 0.7133839 2.288697 0.31467500 0.44100000 0.27150000 -0.16950000 0.007426892 0.003932936 FALSE TRUE
ENST00000399976 ENSG00000156256 HEK293_OSMI2_2hA HEK293_TMG_2hB USP16 protein_coding protein_coding 19.11088 4.444683 35.74847 0.2998952 0.2583606 3.00489 9.7657628 1.6546754 19.257574 0.03338829 0.6004259 3.532862 0.48291250 0.37466667 0.53896667 0.16430000 0.003932936 0.003932936 FALSE TRUE
MSTRG.21206.1 ENSG00000156256 HEK293_OSMI2_2hA HEK293_TMG_2hB USP16 protein_coding   19.11088 4.444683 35.74847 0.2998952 0.2583606 3.00489 0.6730715 0.4133545 1.574723 0.07576946 0.1049521 1.904292 0.03637917 0.09556667 0.04406667 -0.05150000 0.048516629 0.003932936 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156256 E001 0.4545463 0.6269597487 1.000000e+00 1.000000e+00 21 29024252 29024293 42 + 0.135 0.000 -9.017
ENSG00000156256 E002 0.0000000       21 29024619 29024628 10 +      
ENSG00000156256 E003 0.3666179 0.0286069538 1.654940e-01 2.823441e-01 21 29024629 29024648 20 + 0.049 0.274 2.869
ENSG00000156256 E004 0.9694574 0.0415345989 2.028539e-01 3.298000e-01 21 29024649 29024650 2 + 0.171 0.441 1.866
ENSG00000156256 E005 1.4197372 0.0878310306 4.505979e-01 5.916812e-01 21 29024651 29024655 5 + 0.266 0.441 1.057
ENSG00000156256 E006 3.3835329 0.0163903514 9.032503e-01 9.424310e-01 21 29024656 29024667 12 + 0.517 0.561 0.203
ENSG00000156256 E007 132.2143346 0.0047583995 2.035953e-06 1.581342e-05 21 29024668 29024777 110 + 1.998 1.732 -0.896
ENSG00000156256 E008 1.6072813 0.3200346925 3.013954e-01 4.431940e-01 21 29025709 29025771 63 + 0.365 0.000 -10.716
ENSG00000156256 E009 8.4615409 0.0597740520 7.609722e-01 8.449302e-01 21 29026567 29026661 95 + 0.839 0.803 -0.144
ENSG00000156256 E010 186.0579760 0.0013544253 1.118599e-09 1.643645e-08 21 29027873 29027974 102 + 2.144 1.890 -0.855
ENSG00000156256 E011 216.5727341 0.0021757535 2.314138e-07 2.191923e-06 21 29030595 29030773 179 + 2.204 2.003 -0.674
ENSG00000156256 E012 154.0017666 0.0002560161 1.377459e-06 1.109929e-05 21 29034837 29034940 104 + 2.057 1.864 -0.649
ENSG00000156256 E013 153.6361068 0.0002252089 7.247674e-10 1.103827e-08 21 29036271 29036374 104 + 2.063 1.796 -0.898
ENSG00000156256 E014 48.8372550 0.0008300048 6.640734e-07 5.730468e-06 21 29037276 29037278 3 + 1.587 1.152 -1.512
ENSG00000156256 E015 210.1540843 0.0002086472 1.427220e-09 2.055672e-08 21 29037279 29037463 185 + 2.193 1.982 -0.709
ENSG00000156256 E016 163.6117553 0.0002517095 6.647788e-05 3.630765e-04 21 29038335 29038430 96 + 2.080 1.936 -0.484
ENSG00000156256 E017 185.0330494 0.0005213679 2.011232e-02 5.172431e-02 21 29039026 29039156 131 + 2.123 2.058 -0.215
ENSG00000156256 E018 141.7330298 0.0174778808 6.293797e-01 7.447430e-01 21 29039481 29039568 88 + 1.999 1.997 -0.006
ENSG00000156256 E019 105.9316548 0.0056634906 4.475529e-01 5.889292e-01 21 29040609 29040687 79 + 1.862 1.934 0.241
ENSG00000156256 E020 138.4503398 0.0045315913 9.895234e-01 9.974738e-01 21 29042013 29042104 92 + 1.985 2.010 0.086
ENSG00000156256 E021 143.5128177 0.0004067088 5.381768e-01 6.696297e-01 21 29042472 29042528 57 + 2.003 2.005 0.006
ENSG00000156256 E022 11.8107310 0.0015931277 9.572387e-01 9.772061e-01 21 29042529 29043422 894 + 0.958 0.991 0.122
ENSG00000156256 E023 110.0205588 0.0003219550 2.915418e-01 4.324107e-01 21 29043423 29043431 9 + 1.893 1.869 -0.080
ENSG00000156256 E024 243.1714718 0.0001807264 8.883469e-01 9.326181e-01 21 29043432 29043599 168 + 2.227 2.260 0.110
ENSG00000156256 E025 290.8802162 0.0001458964 7.798009e-02 1.562298e-01 21 29046667 29046974 308 + 2.313 2.289 -0.081
ENSG00000156256 E026 261.3392854 0.0003657621 5.429307e-01 6.736258e-01 21 29046975 29047227 253 + 2.255 2.302 0.158
ENSG00000156256 E027 195.4351829 0.0002349078 3.499085e-03 1.172242e-02 21 29047228 29047321 94 + 2.117 2.245 0.427
ENSG00000156256 E028 186.4343392 0.0002106384 4.176229e-06 3.023210e-05 21 29048761 29048855 95 + 2.084 2.269 0.617
ENSG00000156256 E029 180.3691147 0.0002073326 6.975286e-10 1.066113e-08 21 29050092 29050178 87 + 2.059 2.295 0.788
ENSG00000156256 E030 24.7708557 0.0008017988 1.610943e-03 5.995957e-03 21 29052123 29053801 1679 + 1.206 1.502 1.030
ENSG00000156256 E031 237.3351085 0.0034946443 3.831198e-10 6.131696e-09 21 29053802 29053958 157 + 2.170 2.445 0.918
ENSG00000156256 E032 265.5293977 0.0138992860 2.387685e-08 2.741453e-07 21 29054066 29055694 1629 + 2.195 2.565 1.233