ENSG00000156239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303775 ENSG00000156239 HEK293_OSMI2_2hA HEK293_TMG_2hB N6AMT1 protein_coding protein_coding 8.124279 5.729156 9.948446 1.144172 0.4786685 0.7950819 2.7931691 0.8703312 3.1541877 0.8703312 0.2657089 1.845717 0.3138875 0.10870000 0.317033333 0.2083333 1.680001e-01 2.205663e-06 FALSE TRUE
ENST00000351429 ENSG00000156239 HEK293_OSMI2_2hA HEK293_TMG_2hB N6AMT1 protein_coding protein_coding 8.124279 5.729156 9.948446 1.144172 0.4786685 0.7950819 0.7122703 1.1753182 0.3984406 0.5913135 0.3984406 -1.537076 0.1155125 0.25580000 0.042933333 -0.2128667 4.400222e-01 2.205663e-06 FALSE TRUE
ENST00000460212 ENSG00000156239 HEK293_OSMI2_2hA HEK293_TMG_2hB N6AMT1 protein_coding nonsense_mediated_decay 8.124279 5.729156 9.948446 1.144172 0.4786685 0.7950819 1.2364169 2.5053644 0.0649961 0.1638055 0.0649961 -5.067808 0.2139667 0.46403333 0.005966667 -0.4580667 2.205663e-06 2.205663e-06 TRUE TRUE
MSTRG.21187.5 ENSG00000156239 HEK293_OSMI2_2hA HEK293_TMG_2hB N6AMT1 protein_coding   8.124279 5.729156 9.948446 1.144172 0.4786685 0.7950819 1.7490957 0.1794927 3.3606264 0.1794927 0.3463932 4.152802 0.1793417 0.02243333 0.339200000 0.3167667 7.265957e-03 2.205663e-06 TRUE TRUE
MSTRG.21187.6 ENSG00000156239 HEK293_OSMI2_2hA HEK293_TMG_2hB N6AMT1 protein_coding   8.124279 5.729156 9.948446 1.144172 0.4786685 0.7950819 1.4524995 0.9378227 2.8149203 0.6761694 0.5970029 1.575521 0.1523708 0.13636667 0.279733333 0.1433667 5.543343e-01 2.205663e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156239 E001 0.4741261 0.0224775769 7.259224e-01 8.190787e-01 21 28772067 28772138 72 - 0.199 0.135 -0.676
ENSG00000156239 E002 0.3268771 0.0290106014 8.635755e-01   21 28821905 28821973 69 - 0.111 0.135 0.324
ENSG00000156239 E003 9.9831472 0.0018047548 1.017836e-01 1.932182e-01 21 28872191 28872282 92 - 0.961 1.126 0.602
ENSG00000156239 E004 17.3807549 0.0033092219 4.897004e-05 2.765854e-04 21 28872283 28872322 40 - 1.071 1.410 1.199
ENSG00000156239 E005 21.1105375 0.0012740228 9.045236e-06 6.073986e-05 21 28872323 28872394 72 - 1.158 1.489 1.156
ENSG00000156239 E006 50.2812841 0.0056998919 6.378465e-08 6.728554e-07 21 28872395 28872612 218 - 1.533 1.846 1.059
ENSG00000156239 E007 39.1615038 0.0007360317 9.314652e-04 3.724730e-03 21 28872613 28872739 127 - 1.515 1.693 0.609
ENSG00000156239 E008 274.1447347 0.0012753681 8.329437e-03 2.461604e-02 21 28872740 28876311 3572 - 2.474 2.412 -0.207
ENSG00000156239 E009 63.7094860 0.0005255228 1.544268e-01 2.676544e-01 21 28876312 28876491 180 - 1.847 1.783 -0.215
ENSG00000156239 E010 70.7872891 0.0004308223 1.307402e-01 2.351850e-01 21 28878192 28878333 142 - 1.896 1.834 -0.208
ENSG00000156239 E011 36.2430452 0.0038362431 1.329062e-01 2.381549e-01 21 28879870 28879953 84 - 1.627 1.534 -0.315
ENSG00000156239 E012 60.3812250 0.0064544867 3.291100e-01 4.726158e-01 21 28882160 28882250 91 - 1.823 1.769 -0.182
ENSG00000156239 E013 59.9424958 0.0020510512 2.806517e-01 4.205127e-01 21 28882985 28883071 87 - 1.819 1.765 -0.180
ENSG00000156239 E014 47.4162134 0.0101273043 1.124136e-01 2.090549e-01 21 28885212 28885371 160 - 1.741 1.636 -0.356