ENSG00000156232

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286760 ENSG00000156232 HEK293_OSMI2_2hA HEK293_TMG_2hB WHAMM protein_coding protein_coding 5.578337 6.299841 4.740057 0.06320993 0.2648549 -0.4096589 1.3065583 0.9813869 1.7252576 0.5146506 0.1417978 0.8076297 0.2467292 0.15456667 0.36866667 0.2141000 0.51842314 0.01088107 FALSE TRUE
ENST00000560964 ENSG00000156232 HEK293_OSMI2_2hA HEK293_TMG_2hB WHAMM protein_coding retained_intron 5.578337 6.299841 4.740057 0.06320993 0.2648549 -0.4096589 0.7298745 0.1772847 1.3511282 0.1283610 0.3713052 2.8614976 0.1298167 0.02843333 0.27790000 0.2494667 0.01088107 0.01088107 FALSE TRUE
MSTRG.11397.1 ENSG00000156232 HEK293_OSMI2_2hA HEK293_TMG_2hB WHAMM protein_coding   5.578337 6.299841 4.740057 0.06320993 0.2648549 -0.4096589 0.6075142 0.6379029 0.4891781 0.3437253 0.2482214 -0.3762229 0.1236667 0.10110000 0.09780000 -0.0033000 1.00000000 0.01088107 FALSE TRUE
MSTRG.11397.2 ENSG00000156232 HEK293_OSMI2_2hA HEK293_TMG_2hB WHAMM protein_coding   5.578337 6.299841 4.740057 0.06320993 0.2648549 -0.4096589 2.3299197 3.9560699 0.2322415 0.6707856 0.2322415 -4.0331923 0.3957083 0.62853333 0.05483333 -0.5737000 0.01787053 0.01088107 FALSE TRUE
MSTRG.11397.3 ENSG00000156232 HEK293_OSMI2_2hA HEK293_TMG_2hB WHAMM protein_coding   5.578337 6.299841 4.740057 0.06320993 0.2648549 -0.4096589 0.6044707 0.5471967 0.9422514 0.1986770 0.0329870 0.7731559 0.1040875 0.08740000 0.20080000 0.1134000 0.13845595 0.01088107 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156232 E001 0.5503986 0.0206542680 8.859576e-01 9.310435e-01 15 82801850 82801877 28 + 0.146 0.185 0.412
ENSG00000156232 E002 0.4031496 0.0252544729 3.702176e-01 5.146524e-01 15 82801878 82801931 54 + 0.001 0.185 8.747
ENSG00000156232 E003 1.5102910 0.0092485281 6.832453e-01 7.865038e-01 15 82809489 82809627 139 + 0.415 0.367 -0.268
ENSG00000156232 E004 38.9546730 0.0049256342 3.351734e-10 5.408193e-09 15 82809628 82810335 708 + 1.773 1.416 -1.219
ENSG00000156232 E005 41.6898324 0.0060438701 5.528545e-08 5.900322e-07 15 82813103 82813276 174 + 1.779 1.474 -1.040
ENSG00000156232 E006 55.5985018 0.0079042714 2.611542e-03 9.099496e-03 15 82816692 82816842 151 + 1.817 1.672 -0.490
ENSG00000156232 E007 53.7181737 0.0066647945 5.777957e-02 1.228200e-01 15 82817920 82818089 170 + 1.761 1.687 -0.253
ENSG00000156232 E008 50.9616018 0.0005218344 9.271043e-01 9.581322e-01 15 82819323 82819488 166 + 1.671 1.706 0.119
ENSG00000156232 E009 14.0788731 0.0042075838 1.173920e-04 6.018990e-04 15 82821711 82821839 129 + 1.330 1.013 -1.131
ENSG00000156232 E010 78.9682780 0.0008456952 2.022741e-02 5.196175e-02 15 82823100 82823287 188 + 1.914 1.860 -0.183
ENSG00000156232 E011 1.6326496 0.0102005499 4.178357e-02 9.433308e-02 15 82826388 82826409 22 + 0.579 0.254 -1.812
ENSG00000156232 E012 59.6773518 0.0004605642 7.904673e-02 1.579859e-01 15 82826410 82826496 87 + 1.787 1.747 -0.135
ENSG00000156232 E013 61.5687185 0.0080939584 5.822087e-01 7.066093e-01 15 82826751 82826846 96 + 1.773 1.782 0.031
ENSG00000156232 E014 95.6405009 0.0035175983 1.201559e-01 2.202171e-01 15 82830599 82831079 481 + 1.895 2.006 0.375
ENSG00000156232 E015 373.7920860 0.0039099107 1.307671e-13 3.657136e-12 15 82833229 82836178 2950 + 2.396 2.623 0.757