ENSG00000156162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414645 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding protein_coding 10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 4.12379736 0.3536779 7.0811892 0.22799086 0.29114311 4.2852943 0.34648333 0.16793333 0.38583333 0.21790000 3.798474e-01 8.714443e-09 FALSE TRUE
ENST00000520774 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding nonsense_mediated_decay 10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 1.32904956 0.0000000 2.0679807 0.00000000 1.20046193 7.6990384 0.06585833 0.00000000 0.10590000 0.10590000 4.735054e-01 8.714443e-09   FALSE
ENST00000521525 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding protein_coding 10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 0.36527838 0.3612306 0.5455793 0.06964378 0.07383152 0.5816770 0.07822500 0.18156667 0.02933333 -0.15223333 8.714443e-09 8.714443e-09   FALSE
ENST00000522669 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding nonsense_mediated_decay 10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 0.09983681 0.4379525 0.0000000 0.25474980 0.00000000 -5.4852740 0.05657083 0.17553333 0.00000000 -0.17553333 4.967077e-03 8.714443e-09 FALSE FALSE
ENST00000523020 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding protein_coding 10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 0.55557531 0.0000000 1.3793374 0.00000000 0.46767665 7.1182532 0.02857083 0.00000000 0.07353333 0.07353333 7.865254e-03 8.714443e-09 FALSE FALSE
MSTRG.31833.1 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding   10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 1.09370751 0.0000000 1.7791303 0.00000000 0.52725067 7.4831146 0.05809167 0.00000000 0.09923333 0.09923333 2.427989e-03 8.714443e-09 FALSE TRUE
MSTRG.31833.10 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding   10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 1.17617753 0.4766235 2.4080299 0.08219827 0.14844254 2.3129541 0.17315833 0.25936667 0.13193333 -0.12743333 2.179120e-01 8.714443e-09 FALSE TRUE
MSTRG.31833.8 ENSG00000156162 HEK293_OSMI2_2hA HEK293_TMG_2hB DPY19L4 protein_coding   10.46733 2.024151 18.4338 0.4599861 1.050815 3.180637 0.11104172 0.1744952 0.2299107 0.17449524 0.22991074 0.3789142 0.03607083 0.08673333 0.01123333 -0.07550000 7.598749e-01 8.714443e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156162 E001 0.4396707 0.0329102879 1.000000e+00 1.000000e+00 8 94719703 94719833 131 + 0.110 0.000 -8.307
ENSG00000156162 E002 0.2924217 0.0275764682 1.000000e+00   8 94719834 94719853 20 + 0.076 0.000 -9.641
ENSG00000156162 E003 0.1472490 0.0459346470 5.715089e-01   8 94719854 94719874 21 + 0.040 0.000 -8.523
ENSG00000156162 E004 0.1472490 0.0459346470 5.715089e-01   8 94719875 94719877 3 + 0.040 0.000 -8.523
ENSG00000156162 E005 0.1472490 0.0459346470 5.715089e-01   8 94719878 94719878 1 + 0.040 0.000 -8.523
ENSG00000156162 E006 0.1472490 0.0459346470 5.715089e-01   8 94719879 94719882 4 + 0.040 0.000 -8.523
ENSG00000156162 E007 0.1472490 0.0459346470 5.715089e-01   8 94719883 94719884 2 + 0.040 0.000 -8.523
ENSG00000156162 E008 1.0351233 0.0120289861 6.990773e-01 7.989075e-01 8 94719885 94719891 7 + 0.223 0.000 -11.460
ENSG00000156162 E009 2.6249116 0.0057455811 7.139377e-01 8.102836e-01 8 94719892 94719899 8 + 0.388 0.506 0.615
ENSG00000156162 E010 35.4604929 0.0008090107 1.856033e-01 3.082492e-01 8 94719900 94720014 115 + 1.347 1.270 -0.267
ENSG00000156162 E011 2.0586173 0.0954601805 2.330071e-01 3.659968e-01 8 94720102 94720236 135 + 0.313 0.629 1.627
ENSG00000156162 E012 43.6549364 0.0005584057 6.242876e-02 1.307350e-01 8 94726331 94726395 65 + 1.436 1.319 -0.407
ENSG00000156162 E013 28.7850167 0.0014064088 4.430272e-02 9.893576e-02 8 94726396 94726401 6 + 1.267 1.080 -0.664
ENSG00000156162 E014 36.0540832 0.0006623291 1.036313e-01 1.960265e-01 8 94726402 94726441 40 + 1.354 1.244 -0.385
ENSG00000156162 E015 37.4144475 0.0046178900 5.700909e-01 6.965986e-01 8 94734630 94734754 125 + 1.362 1.362 0.002
ENSG00000156162 E016 40.2876534 0.0086462271 4.053203e-02 9.200091e-02 8 94738369 94738459 91 + 1.408 1.242 -0.579
ENSG00000156162 E017 52.0916450 0.0004563751 3.133389e-02 7.455086e-02 8 94739413 94739519 107 + 1.512 1.383 -0.444
ENSG00000156162 E018 31.8941373 0.0006678419 2.730111e-01 4.119893e-01 8 94739520 94739534 15 + 1.301 1.244 -0.201
ENSG00000156162 E019 25.5472748 0.0017983707 6.161318e-02 1.293359e-01 8 94739645 94739649 5 + 1.219 1.038 -0.648
ENSG00000156162 E020 63.5229455 0.0003780451 8.878800e-02 1.732638e-01 8 94739650 94739790 141 + 1.589 1.518 -0.243
ENSG00000156162 E021 4.8464676 0.0042851709 1.789296e-03 6.565247e-03 8 94744343 94744484 142 + 0.493 1.038 2.231
ENSG00000156162 E022 32.2439371 0.0006839764 4.015152e-15 1.401103e-13 8 94744485 94745084 600 + 1.182 1.813 2.170
ENSG00000156162 E023 45.4950514 0.0006277361 1.555628e-04 7.718735e-04 8 94756036 94756159 124 + 1.466 1.118 -1.219
ENSG00000156162 E024 15.8666516 0.0011096400 8.662765e-03 2.544001e-02 8 94761700 94761701 2 + 1.041 0.634 -1.594
ENSG00000156162 E025 43.8793104 0.0019980951 4.123496e-05 2.369594e-04 8 94761702 94761834 133 + 1.454 1.038 -1.469
ENSG00000156162 E026 36.2847201 0.0010975089 2.537440e-03 8.875745e-03 8 94765183 94765314 132 + 1.371 1.080 -1.027
ENSG00000156162 E027 35.2897374 0.0005717438 1.986342e-01 3.244805e-01 8 94765711 94765809 99 + 1.343 1.271 -0.253
ENSG00000156162 E028 34.6843097 0.0006090211 1.393450e-01 2.471514e-01 8 94766612 94766685 74 + 1.339 1.244 -0.334
ENSG00000156162 E029 55.2214024 0.0007790870 2.153529e-01 3.448365e-01 8 94768395 94768553 159 + 1.530 1.488 -0.142
ENSG00000156162 E030 45.0179154 0.0057177591 8.776654e-02 1.717446e-01 8 94770452 94770571 120 + 1.450 1.340 -0.382
ENSG00000156162 E031 23.3744313 0.0009681505 2.717634e-02 6.635232e-02 8 94777666 94777677 12 + 1.185 0.940 -0.891
ENSG00000156162 E032 47.7265465 0.0004875607 2.028006e-02 5.207117e-02 8 94777678 94777786 109 + 1.476 1.319 -0.543
ENSG00000156162 E033 42.3887803 0.0006017992 2.975580e-02 7.147844e-02 8 94780359 94780415 57 + 1.426 1.271 -0.539
ENSG00000156162 E034 49.4070899 0.0027554526 1.792597e-01 3.001928e-01 8 94781084 94781166 83 + 1.483 1.421 -0.212
ENSG00000156162 E035 51.9114165 0.0006570477 7.656124e-01 8.483235e-01 8 94783670 94783802 133 + 1.496 1.532 0.124
ENSG00000156162 E036 66.6896000 0.0009628115 2.577422e-01 3.949151e-01 8 94787894 94788052 159 + 1.608 1.585 -0.079
ENSG00000156162 E037 461.0756081 0.0040329359 7.024788e-13 1.767834e-11 8 94789746 94793836 4091 + 2.403 2.668 0.882