ENSG00000156030

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394071 ENSG00000156030 HEK293_OSMI2_2hA HEK293_TMG_2hB MIDEAS protein_coding protein_coding 6.702701 6.31645 6.547286 0.390559 0.3238911 0.0517027 0.6499512 0.34317162 0.8750134 0.17289866 0.1029163 1.3253298 0.09892083 0.057433333 0.13576667 0.07833333 4.519290e-01 9.392251e-14 FALSE TRUE
ENST00000423556 ENSG00000156030 HEK293_OSMI2_2hA HEK293_TMG_2hB MIDEAS protein_coding protein_coding 6.702701 6.31645 6.547286 0.390559 0.3238911 0.0517027 3.9439628 3.06016544 4.4551944 0.64592072 0.2488847 0.5404066 0.58760000 0.475200000 0.68063333 0.20543333 1.181442e-01 9.392251e-14 FALSE TRUE
ENST00000476562 ENSG00000156030 HEK293_OSMI2_2hA HEK293_TMG_2hB MIDEAS protein_coding retained_intron 6.702701 6.31645 6.547286 0.390559 0.3238911 0.0517027 1.1256779 2.51727060 0.0000000 0.34105935 0.0000000 -7.9814363 0.16730833 0.408366667 0.00000000 -0.40836667 9.392251e-14 9.392251e-14 FALSE TRUE
ENST00000478847 ENSG00000156030 HEK293_OSMI2_2hA HEK293_TMG_2hB MIDEAS protein_coding retained_intron 6.702701 6.31645 6.547286 0.390559 0.3238911 0.0517027 0.2338878 0.05802506 0.4748611 0.05802506 0.1079852 2.8334334 0.03399583 0.008466667 0.07236667 0.06390000 4.536167e-02 9.392251e-14   FALSE
ENST00000483269 ENSG00000156030 HEK293_OSMI2_2hA HEK293_TMG_2hB MIDEAS protein_coding retained_intron 6.702701 6.31645 6.547286 0.390559 0.3238911 0.0517027 0.2767023 0.00000000 0.4426886 0.00000000 0.2014330 5.5004471 0.04111667 0.000000000 0.06493333 0.06493333 6.790583e-04 9.392251e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000156030 E001 1.399472 0.0096225466 1.732307e-03 6.384770e-03 14 73715122 73715123 2 - 0.000 0.603 12.342
ENSG00000156030 E002 1.769210 0.0087749391 4.039593e-04 1.789814e-03 14 73715124 73715130 7 - 0.000 0.678 15.068
ENSG00000156030 E003 689.256180 0.0093630239 4.152423e-15 1.445542e-13 14 73715131 73718370 3240 - 2.625 2.993 1.225
ENSG00000156030 E004 53.887276 0.0004911541 4.885000e-01 6.260519e-01 14 73718371 73718742 372 - 1.652 1.809 0.532
ENSG00000156030 E005 23.323151 0.0008184896 1.123238e-02 3.172290e-02 14 73718743 73718846 104 - 1.410 1.352 -0.203
ENSG00000156030 E006 38.633505 0.0028620804 1.866360e-02 4.859286e-02 14 73718847 73719008 162 - 1.600 1.580 -0.065
ENSG00000156030 E007 1.591877 0.0084602132 5.340110e-01 6.661275e-01 14 73719009 73719304 296 - 0.429 0.399 -0.162
ENSG00000156030 E008 33.596358 0.0007579730 5.629313e-02 1.202291e-01 14 73719305 73719369 65 - 1.526 1.534 0.026
ENSG00000156030 E009 20.281117 0.0009281177 1.912523e-01 3.153092e-01 14 73719370 73719381 12 - 1.315 1.337 0.076
ENSG00000156030 E010 36.220142 0.0006263214 1.815385e-02 4.746202e-02 14 73719382 73719501 120 - 1.574 1.562 -0.044
ENSG00000156030 E011 56.968083 0.0004260603 6.695207e-02 1.383071e-01 14 73721297 73721509 213 - 1.742 1.782 0.135
ENSG00000156030 E012 1.330765 0.0104331701 1.549148e-01 2.683062e-01 14 73721510 73721624 115 - 0.429 0.244 -1.159
ENSG00000156030 E013 1.767216 0.0098813825 1.053922e-04 5.468851e-04 14 73722366 73722697 332 - 0.641 0.000 -15.394
ENSG00000156030 E014 55.033131 0.0004228726 1.758241e-04 8.604175e-04 14 73722698 73722847 150 - 1.770 1.718 -0.175
ENSG00000156030 E015 5.287497 0.0039312430 9.338437e-03 2.712945e-02 14 73723162 73725271 2110 - 0.889 0.643 -0.990
ENSG00000156030 E016 40.755989 0.0032475333 2.518296e-05 1.525691e-04 14 73725272 73725360 89 - 1.680 1.552 -0.439
ENSG00000156030 E017 31.975702 0.0007743206 1.687760e-03 6.243966e-03 14 73726033 73726108 76 - 1.548 1.478 -0.240
ENSG00000156030 E018 31.672847 0.0206699293 1.095310e-01 2.048786e-01 14 73726604 73726707 104 - 1.519 1.506 -0.047
ENSG00000156030 E019 33.408912 0.0114431795 5.840527e-02 1.238965e-01 14 73726830 73726972 143 - 1.541 1.522 -0.064
ENSG00000156030 E020 2.699017 0.0061314944 9.955621e-01 1.000000e+00 14 73726973 73727457 485 - 0.512 0.604 0.425
ENSG00000156030 E021 27.493734 0.0007050051 5.943058e-02 1.256621e-01 14 73727458 73727524 67 - 1.451 1.449 -0.006
ENSG00000156030 E022 6.714870 0.0054361468 7.282772e-02 1.480459e-01 14 73727525 73729176 1652 - 0.934 0.823 -0.424
ENSG00000156030 E023 66.038436 0.0003650755 2.603431e-08 2.967855e-07 14 73729640 73729985 346 - 1.873 1.757 -0.390
ENSG00000156030 E024 1.284681 0.0099405494 1.546830e-01 2.679931e-01 14 73730070 73730179 110 - 0.429 0.244 -1.160
ENSG00000156030 E025 61.012418 0.0004596521 7.726624e-09 9.724213e-08 14 73736998 73737297 300 - 1.846 1.709 -0.463
ENSG00000156030 E026 87.200086 0.0005147630 1.063104e-06 8.772239e-06 14 73738560 73739312 753 - 1.967 1.906 -0.203
ENSG00000156030 E027 20.136187 0.0011838386 6.700240e-02 1.383869e-01 14 73739313 73739354 42 - 1.333 1.314 -0.066
ENSG00000156030 E028 24.290572 0.0152584384 4.982490e-02 1.088467e-01 14 73739355 73739438 84 - 1.429 1.373 -0.194
ENSG00000156030 E029 46.438282 0.0556035982 9.646421e-02 1.850506e-01 14 73739439 73739811 373 - 1.694 1.648 -0.155
ENSG00000156030 E030 36.661319 0.0019178687 2.003613e-02 5.156405e-02 14 73739812 73740030 219 - 1.574 1.558 -0.056
ENSG00000156030 E031 37.895300 0.0007489311 1.056446e-03 4.154706e-03 14 73740031 73740255 225 - 1.612 1.548 -0.217
ENSG00000156030 E032 0.000000       14 73754903 73755016 114 -      
ENSG00000156030 E033 20.062953 0.0325821050 1.899073e-03 6.911680e-03 14 73759763 73760133 371 - 1.415 1.180 -0.820
ENSG00000156030 E034 5.764263 0.1077301569 1.975443e-01 3.231459e-01 14 73760134 73760303 170 - 0.872 0.754 -0.462
ENSG00000156030 E035 6.590637 0.0024811440 9.071082e-02 1.762535e-01 14 73787102 73787258 157 - 0.919 0.823 -0.369
ENSG00000156030 E036 0.000000       14 73789825 73789959 135 -      
ENSG00000156030 E037 0.000000       14 73790112 73790285 174 -