ENSG00000155980

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455537 ENSG00000155980 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5A protein_coding protein_coding 5.62954 5.69555 4.332954 0.460619 0.29897 -0.3936894 2.6768380 2.250468 2.2939592 0.27514922 0.2596903 0.02749375 0.48549583 0.4029000 0.5280333 0.12513333 4.284645e-01 7.727521e-10 FALSE TRUE
ENST00000674858 ENSG00000155980 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5A protein_coding protein_coding 5.62954 5.69555 4.332954 0.460619 0.29897 -0.3936894 0.3626882 0.000000 0.5727459 0.00000000 0.2941636 5.86479511 0.06333750 0.0000000 0.1235000 0.12350000 1.379679e-01 7.727521e-10   FALSE
ENST00000674980 ENSG00000155980 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5A protein_coding protein_coding 5.62954 5.69555 4.332954 0.460619 0.29897 -0.3936894 0.4539499 1.698850 0.0000000 0.46693143 0.0000000 -7.41688223 0.07290833 0.2936333 0.0000000 -0.29363333 7.727521e-10 7.727521e-10 FALSE FALSE
ENST00000676437 ENSG00000155980 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5A protein_coding protein_coding 5.62954 5.69555 4.332954 0.460619 0.29897 -0.3936894 1.2095674 1.193898 0.6643781 0.09398551 0.1372560 -0.83608347 0.20690417 0.2097333 0.1595667 -0.05016667 6.154161e-01 7.727521e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155980 E001 0.1482932 0.0412478532 5.458148e-01   12 57546026 57546312 287 + 0.000 0.117 9.285
ENSG00000155980 E002 0.1472490 0.0426678294 4.358877e-01   12 57550027 57550043 17 + 0.127 0.000 -13.154
ENSG00000155980 E003 3.6752571 0.0575880595 1.495477e-01 2.610487e-01 12 57550044 57550065 22 + 0.785 0.544 -1.027
ENSG00000155980 E004 7.2330918 0.0026941626 3.190551e-03 1.082780e-02 12 57550066 57550104 39 + 1.062 0.729 -1.274
ENSG00000155980 E005 22.8553486 0.0010379701 9.219628e-05 4.852831e-04 12 57550105 57550400 296 + 1.509 1.250 -0.898
ENSG00000155980 E006 0.1451727 0.0426366204 4.361286e-01   12 57550401 57550791 391 + 0.127 0.000 -13.154
ENSG00000155980 E007 0.0000000       12 57561518 57561554 37 +      
ENSG00000155980 E008 10.8185883 0.0083326855 1.123366e-02 3.172414e-02 12 57563439 57563526 88 + 1.203 0.957 -0.894
ENSG00000155980 E009 12.5588704 0.0018403524 1.890244e-02 4.911952e-02 12 57563620 57563693 74 + 1.239 1.040 -0.714
ENSG00000155980 E010 18.2311312 0.0101925233 7.681470e-03 2.298013e-02 12 57564108 57564212 105 + 1.401 1.182 -0.766
ENSG00000155980 E011 14.4915190 0.0012612601 4.179718e-04 1.843363e-03 12 57564460 57564508 49 + 1.331 1.040 -1.035
ENSG00000155980 E012 18.9021374 0.0010201594 5.064421e-03 1.610635e-02 12 57564918 57564973 56 + 1.401 1.202 -0.693
ENSG00000155980 E013 20.2816463 0.0009435082 1.514765e-01 2.636819e-01 12 57567126 57567213 88 + 1.370 1.280 -0.314
ENSG00000155980 E014 26.2624611 0.0008420340 4.612763e-02 1.022745e-01 12 57567494 57567618 125 + 1.490 1.375 -0.397
ENSG00000155980 E015 24.0674452 0.0008194586 7.612059e-02 1.533020e-01 12 57568963 57569067 105 + 1.456 1.352 -0.359
ENSG00000155980 E016 12.6817755 0.0013865004 2.560540e-01 3.930023e-01 12 57569256 57569290 35 + 1.184 1.097 -0.311
ENSG00000155980 E017 22.0587954 0.0019255428 8.769924e-01 9.250138e-01 12 57569291 57569404 114 + 1.357 1.364 0.022
ENSG00000155980 E018 14.7099479 0.0187963153 3.756120e-01 5.200304e-01 12 57569535 57569579 45 + 1.238 1.158 -0.286
ENSG00000155980 E019 18.9706402 0.0010119893 5.858814e-02 1.242080e-01 12 57569580 57569683 104 + 1.364 1.235 -0.449
ENSG00000155980 E020 21.8891169 0.0009742279 6.709957e-03 2.046958e-02 12 57569987 57570162 176 + 1.445 1.266 -0.624
ENSG00000155980 E021 15.3343414 0.0021154952 4.103759e-01 5.539701e-01 12 57571321 57571389 69 + 1.239 1.185 -0.189
ENSG00000155980 E022 0.0000000       12 57571589 57571609 21 +      
ENSG00000155980 E023 0.0000000       12 57571769 57572060 292 +      
ENSG00000155980 E024 16.0583790 0.0013930883 2.994965e-01 4.410110e-01 12 57572061 57572140 80 + 1.264 1.194 -0.245
ENSG00000155980 E025 23.9789452 0.0009368609 7.126623e-01 8.093291e-01 12 57572141 57572267 127 + 1.395 1.387 -0.028
ENSG00000155980 E026 0.9117205 0.0510257533 7.657482e-02 1.540122e-01 12 57572268 57572449 182 + 0.431 0.118 -2.447
ENSG00000155980 E027 1.4780283 0.0093257246 4.109008e-03 1.344803e-02 12 57572450 57572579 130 + 0.609 0.118 -3.298
ENSG00000155980 E028 16.1256016 0.0014324082 6.409577e-01 7.540696e-01 12 57572580 57572624 45 + 1.194 1.251 0.201
ENSG00000155980 E029 22.0404364 0.0010551496 3.181995e-01 4.611567e-01 12 57572625 57572726 102 + 1.383 1.327 -0.192
ENSG00000155980 E030 22.3007601 0.0009897869 6.335484e-02 1.322854e-01 12 57575084 57575272 189 + 1.423 1.308 -0.402
ENSG00000155980 E031 0.0000000       12 57575273 57575319 47 +      
ENSG00000155980 E032 21.0771351 0.0213701498 3.696800e-01 5.140771e-01 12 57575640 57575757 118 + 1.383 1.306 -0.266
ENSG00000155980 E033 0.1451727 0.0426366204 4.361286e-01   12 57575758 57576086 329 + 0.127 0.000 -13.154
ENSG00000155980 E034 16.7198225 0.0272678096 2.650300e-01 4.030435e-01 12 57576087 57576151 65 + 1.302 1.188 -0.403
ENSG00000155980 E035 1.1113958 0.0117847683 3.349142e-02 7.875538e-02 12 57576152 57576268 117 + 0.483 0.118 -2.711
ENSG00000155980 E036 25.4702767 0.0008161605 3.756006e-02 8.651341e-02 12 57576269 57576378 110 + 1.481 1.358 -0.424
ENSG00000155980 E037 1.0330470 0.0119082454 2.264956e-03 8.045473e-03 12 57576379 57576760 382 + 0.529 0.000 -15.934
ENSG00000155980 E038 17.2953056 0.0011158827 1.789786e-01 2.998650e-01 12 57576761 57576792 32 + 1.309 1.219 -0.317
ENSG00000155980 E039 26.3602179 0.0007554858 3.755551e-02 8.650713e-02 12 57576793 57576862 70 + 1.500 1.381 -0.410
ENSG00000155980 E040 24.3096660 0.0028216659 2.775387e-01 4.171172e-01 12 57577713 57577773 61 + 1.434 1.375 -0.205
ENSG00000155980 E041 1.3381542 0.0096765512 4.536074e-04 1.981063e-03 12 57577774 57578008 235 + 0.609 0.000 -16.251
ENSG00000155980 E042 23.2512466 0.0088781778 7.857311e-01 8.627437e-01 12 57578009 57578080 72 + 1.382 1.381 -0.005
ENSG00000155980 E043 23.0096499 0.0163916427 6.093368e-01 7.288520e-01 12 57578238 57578330 93 + 1.337 1.408 0.244
ENSG00000155980 E044 12.9174595 0.0014742102 5.698384e-02 1.214305e-01 12 57578331 57578342 12 + 1.022 1.219 0.708
ENSG00000155980 E045 0.5963950 0.3646858062 5.740117e-01 6.998905e-01 12 57578343 57579185 843 + 0.127 0.277 1.386
ENSG00000155980 E046 0.0000000       12 57579186 57579206 21 +      
ENSG00000155980 E047 0.2965864 0.2091861777 2.909097e-01   12 57579207 57579885 679 + 0.000 0.207 12.436
ENSG00000155980 E048 17.9435671 0.0010257775 5.236775e-01 6.573058e-01 12 57580956 57581013 58 + 1.239 1.307 0.241
ENSG00000155980 E049 11.5507828 0.0015811102 6.864081e-01 7.889264e-01 12 57581014 57581014 1 + 1.062 1.119 0.203
ENSG00000155980 E050 29.6075771 0.0023602767 5.723955e-01 6.985133e-01 12 57581015 57581172 158 + 1.495 1.476 -0.065
ENSG00000155980 E051 0.0000000       12 57581382 57581414 33 +      
ENSG00000155980 E052 23.5148260 0.0061860319 8.281848e-01 8.920337e-01 12 57581415 57581568 154 + 1.370 1.407 0.126
ENSG00000155980 E053 1.0611596 0.0478948009 4.093314e-02 9.276020e-02 12 57581569 57581677 109 + 0.483 0.118 -2.711
ENSG00000155980 E054 1.0267042 0.0160805390 2.365358e-03 8.353869e-03 12 57581678 57581869 192 + 0.529 0.000 -15.906
ENSG00000155980 E055 16.0927091 0.0275558019 7.648964e-01 8.478372e-01 12 57581870 57581935 66 + 1.203 1.260 0.201
ENSG00000155980 E056 12.0756754 0.0101778818 5.591397e-01 6.872853e-01 12 57581936 57581952 17 + 1.075 1.156 0.291
ENSG00000155980 E057 2.0368579 0.0077909199 2.907054e-01 4.315183e-01 12 57581953 57582601 649 + 0.571 0.407 -0.807
ENSG00000155980 E058 11.2179769 0.0130437596 1.319449e-01 2.368270e-01 12 57582602 57582613 12 + 0.978 1.165 0.679
ENSG00000155980 E059 11.9241454 0.0015450770 2.373848e-01 3.711451e-01 12 57582614 57582629 16 + 1.036 1.167 0.473
ENSG00000155980 E060 6.9923473 0.0028113431 4.232743e-01 5.663597e-01 12 57582630 57582776 147 + 0.831 0.944 0.429
ENSG00000155980 E061 7.4781162 0.0022462367 8.802002e-01 9.271583e-01 12 57582777 57582854 78 + 0.929 0.928 -0.002
ENSG00000155980 E062 3.7578869 0.0056438488 5.342749e-02 1.152496e-01 12 57582855 57582861 7 + 0.809 0.543 -1.128
ENSG00000155980 E063 9.7227809 0.0017445278 3.116344e-02 7.421521e-02 12 57582862 57583100 239 + 1.133 0.928 -0.752
ENSG00000155980 E064 20.6589133 0.0011151128 2.903562e-01 4.311544e-01 12 57583101 57583215 115 + 1.272 1.370 0.342
ENSG00000155980 E065 13.6685525 0.0012852420 1.074927e-01 2.018412e-01 12 57583216 57583475 260 + 1.062 1.227 0.590
ENSG00000155980 E066 34.0735361 0.0006651757 7.537554e-01 8.395830e-01 12 57583476 57584217 742 + 1.540 1.539 -0.002
ENSG00000155980 E067 98.0002558 0.0114720310 8.150333e-02 1.619034e-01 12 57584218 57585129 912 + 1.915 2.037 0.408
ENSG00000155980 E068 78.9066249 0.0064214403 3.783909e-08 4.177692e-07 12 57585130 57585605 476 + 1.687 2.007 1.080
ENSG00000155980 E069 126.2268392 0.0041841465 1.065611e-17 5.217801e-16 12 57585606 57586633 1028 + 1.837 2.228 1.311