ENSG00000155975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324849 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding protein_coding 10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 1.0227581 0.3029454 2.037067 0.07030384 0.2011994 2.7095754 0.09840417 0.05536667 0.13740000 0.08203333 0.0758955991 0.0002262312 FALSE TRUE
ENST00000519381 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding nonsense_mediated_decay 10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 0.5939077 0.0000000 1.287273 0.00000000 0.7711425 7.0193381 0.04422917 0.00000000 0.08356667 0.08356667 0.3014800380 0.0002262312   FALSE
ENST00000521829 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding protein_coding 10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 0.9399203 1.5357418 1.041240 0.34818203 0.3197463 -0.5562074 0.10351667 0.24770000 0.06853333 -0.17916667 0.0002262312 0.0002262312 FALSE TRUE
ENST00000521976 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding protein_coding 10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 1.0645530 0.8319310 1.331666 0.11570651 0.1720540 0.6722519 0.12204583 0.13866667 0.08973333 -0.04893333 0.2510869681 0.0002262312 FALSE TRUE
MSTRG.31209.11 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding   10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 1.9411706 0.1840475 3.217649 0.18404753 0.6044728 4.0560019 0.14848750 0.02290000 0.21506667 0.19216667 0.0393592803 0.0002262312 FALSE TRUE
MSTRG.31209.7 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding   10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 2.4192487 1.6364636 3.361513 0.04318508 0.4880536 1.0340256 0.24015833 0.28083333 0.22813333 -0.05270000 0.7395986039 0.0002262312 FALSE TRUE
MSTRG.31209.9 ENSG00000155975 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS37A protein_coding   10.38225 6.08339 14.93314 0.9846032 0.5777871 1.294166 1.0462933 0.6436130 1.129376 0.26688015 0.5705225 0.8017359 0.09264583 0.09836667 0.07406667 -0.02430000 0.8288072935 0.0002262312 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155975 E001 0.9222159 0.3122273461 5.782461e-01 7.033920e-01 8 17246931 17246933 3 + 0.326 0.169 -1.239
ENSG00000155975 E002 1.0673886 0.0863901689 3.303739e-01 4.739603e-01 8 17246934 17246937 4 + 0.370 0.168 -1.505
ENSG00000155975 E003 3.8363390 0.0040338427 3.783526e-01 5.226307e-01 8 17246938 17246953 16 + 0.721 0.584 -0.585
ENSG00000155975 E004 4.5759321 0.0034511973 2.947076e-01 4.358259e-01 8 17246954 17246957 4 + 0.789 0.634 -0.639
ENSG00000155975 E005 5.6110554 0.0028412485 7.469993e-02 1.510575e-01 8 17246958 17246965 8 + 0.888 0.634 -1.022
ENSG00000155975 E006 11.2793656 0.0016092566 1.688142e-01 2.866401e-01 8 17246966 17246982 17 + 1.124 0.978 -0.534
ENSG00000155975 E007 11.2449102 0.0016017325 1.009894e-01 1.919756e-01 8 17246983 17246983 1 + 1.132 0.956 -0.642
ENSG00000155975 E008 21.3346773 0.0009330355 3.605491e-01 5.048706e-01 8 17246984 17247009 26 + 1.361 1.289 -0.252
ENSG00000155975 E009 38.5531817 0.0005837727 1.710282e-01 2.895202e-01 8 17247010 17247093 84 + 1.614 1.533 -0.277
ENSG00000155975 E010 29.8294488 0.0007818986 3.009158e-01 4.426915e-01 8 17247094 17247122 29 + 1.501 1.431 -0.239
ENSG00000155975 E011 51.5671739 0.0015878544 3.449944e-01 4.890687e-01 8 17247123 17247243 121 + 1.726 1.675 -0.173
ENSG00000155975 E012 43.4846496 0.0015419437 6.086273e-01 7.283025e-01 8 17247244 17247369 126 + 1.646 1.615 -0.106
ENSG00000155975 E013 1.1821688 0.8829634503 6.575253e-01 7.668632e-01 8 17247655 17248007 353 + 0.277 0.435 0.945
ENSG00000155975 E014 0.0000000       8 17248310 17248417 108 +      
ENSG00000155975 E015 0.4386386 0.1093970184 1.000000e+00 1.000000e+00 8 17265771 17265815 45 + 0.161 0.167 0.071
ENSG00000155975 E016 30.6248383 0.0006688971 8.080640e-01 8.780412e-01 8 17265907 17265981 75 + 1.492 1.475 -0.058
ENSG00000155975 E017 46.6776149 0.0004673270 8.672643e-01 9.186355e-01 8 17268258 17268372 115 + 1.667 1.657 -0.033
ENSG00000155975 E018 49.9431603 0.0005020780 3.498498e-01 4.940367e-01 8 17268856 17268956 101 + 1.711 1.662 -0.166
ENSG00000155975 E019 0.0000000       8 17271993 17272063 71 +      
ENSG00000155975 E020 42.6694451 0.0015693632 1.068793e-01 2.009388e-01 8 17274733 17274775 43 + 1.661 1.567 -0.320
ENSG00000155975 E021 102.2675924 0.0004949921 6.522691e-01 7.629877e-01 8 17274776 17274958 183 + 2.009 1.992 -0.054
ENSG00000155975 E022 64.7910316 0.0004690009 7.784746e-01 8.574649e-01 8 17276397 17276435 39 + 1.800 1.812 0.041
ENSG00000155975 E023 57.1806362 0.0010200072 7.148193e-01 8.109101e-01 8 17276436 17276467 32 + 1.742 1.758 0.054
ENSG00000155975 E024 0.4741261 0.0215214883 1.000000e+00 1.000000e+00 8 17279722 17280027 306 + 0.161 0.168 0.079
ENSG00000155975 E025 81.3791646 0.0016272252 5.313275e-01 6.637985e-01 8 17280028 17280155 128 + 1.895 1.922 0.090
ENSG00000155975 E026 53.8814883 0.0025328940 4.069587e-01 5.505993e-01 8 17280239 17280297 59 + 1.713 1.756 0.147
ENSG00000155975 E027 1.3545237 0.1232194659 5.158852e-01 6.504988e-01 8 17280298 17280374 77 + 0.326 0.456 0.735
ENSG00000155975 E028 38.0009847 0.0006367814 1.918881e-01 3.161345e-01 8 17280375 17280392 18 + 1.550 1.624 0.254
ENSG00000155975 E029 59.2478569 0.0005237920 7.846415e-02 1.570186e-01 8 17280393 17280443 51 + 1.740 1.821 0.272
ENSG00000155975 E030 82.6323948 0.0003494222 2.386697e-02 5.953292e-02 8 17284473 17284616 144 + 1.876 1.963 0.292
ENSG00000155975 E031 65.4649967 0.0003798642 1.437164e-02 3.907270e-02 8 17286347 17286427 81 + 1.768 1.874 0.357
ENSG00000155975 E032 5.9795395 0.0038961675 1.198930e-02 3.350648e-02 8 17286428 17286611 184 + 0.682 0.999 1.239
ENSG00000155975 E033 3.3117822 0.0308971565 5.621421e-03 1.760849e-02 8 17293719 17293774 56 + 0.410 0.853 1.968
ENSG00000155975 E034 90.5318951 0.0003094698 9.887012e-08 1.004863e-06 8 17294987 17295963 977 + 1.871 2.064 0.649
ENSG00000155975 E035 23.0963344 0.0063261685 1.466705e-06 1.175343e-05 8 17295964 17296412 449 + 1.482 1.020 -1.633
ENSG00000155975 E036 6.5118306 0.0026297421 1.909857e-03 6.946525e-03 8 17296413 17296460 48 + 0.978 0.527 -1.848
ENSG00000155975 E037 7.6265624 0.0145513339 7.113851e-04 2.939504e-03 8 17296461 17296567 107 + 1.045 0.527 -2.090
ENSG00000155975 E038 41.6152509 0.0011740773 5.168439e-07 4.558829e-06 8 17296568 17298024 1457 + 1.703 1.383 -1.095
ENSG00000155975 E039 3.5147710 0.0338041175 9.886301e-01 9.969500e-01 8 17298067 17298106 40 + 0.640 0.635 -0.020
ENSG00000155975 E040 2.9883204 0.0158549408 3.139678e-01 4.566275e-01 8 17298107 17298158 52 + 0.639 0.462 -0.826
ENSG00000155975 E041 0.2966881 0.0270359831 5.125164e-01   8 17299819 17299854 36 + 0.161 0.000 -9.420
ENSG00000155975 E042 4.7597233 0.0034542813 5.983376e-01 7.199592e-01 8 17299855 17300282 428 + 0.721 0.792 0.289
ENSG00000155975 E043 1.2931122 0.0100343058 3.008201e-01 4.425850e-01 8 17302214 17302427 214 + 0.278 0.461 1.078
ENSG00000155975 E044 0.5901540 0.0195775844 7.765881e-01 8.561194e-01 8 17325054 17325086 33 + 0.223 0.168 -0.508
ENSG00000155975 E045 3.4236480 0.0500938045 7.078607e-01 8.056502e-01 8 17330270 17330453 184 + 0.617 0.678 0.263