ENSG00000155903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000286364 ENSG00000155903 HEK293_OSMI2_2hA HEK293_TMG_2hB RASA2 protein_coding protein_coding 2.820749 0.6055875 4.95383 0.07673308 0.1518089 3.011418 1.607416 0.07000773 3.219649 0.07000773 0.2150374 5.335094 0.5891750 0.09343333 0.6485000 0.5550667 0.003917287 0.003917287 FALSE TRUE
MSTRG.23817.1 ENSG00000155903 HEK293_OSMI2_2hA HEK293_TMG_2hB RASA2 protein_coding   2.820749 0.6055875 4.95383 0.07673308 0.1518089 3.011418 1.066981 0.53557982 1.667232 0.02716628 0.1320058 1.620220 0.3759583 0.90656667 0.3387333 -0.5678333 0.004747572 0.003917287 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155903 E001 0.2987644 0.0274378968 1.000000e+00   3 141487022 141487026 5 + 0.088 0.000 -7.718
ENSG00000155903 E002 1.7820913 0.0080893325 1.832408e-01 0.3052689228 3 141487027 141487046 20 + 0.369 0.000 -11.893
ENSG00000155903 E003 8.7447309 0.0020162012 3.792655e-03 0.0125613124 3 141487047 141487182 136 + 0.873 0.290 -2.770
ENSG00000155903 E004 7.4986552 0.0022024259 1.817113e-01 0.3033865473 3 141487183 141487216 34 + 0.796 0.585 -0.881
ENSG00000155903 E005 14.7508355 0.0115433789 3.417014e-02 0.0800850042 3 141512163 141512280 118 + 1.060 0.759 -1.144
ENSG00000155903 E006 16.2298959 0.0072309610 1.372195e-02 0.0375901067 3 141516328 141516431 104 + 1.100 0.759 -1.290
ENSG00000155903 E007 19.0058920 0.0010484012 2.859797e-01 0.4263531239 3 141529708 141529802 95 + 1.144 1.058 -0.311
ENSG00000155903 E008 15.2367585 0.0293423968 7.055333e-01 0.8038754092 3 141540533 141540609 77 + 1.034 1.123 0.325
ENSG00000155903 E009 16.8520090 0.0233810026 4.491400e-01 0.5903370220 3 141553857 141553940 84 + 1.093 1.020 -0.264
ENSG00000155903 E010 16.2791255 0.0041008684 3.503156e-03 0.0117341902 3 141555840 141555912 73 + 1.104 0.681 -1.626
ENSG00000155903 E011 20.0261678 0.0009971747 6.218454e-02 0.1303215125 3 141558886 141558962 77 + 1.171 0.980 -0.696
ENSG00000155903 E012 19.7788106 0.0012269194 1.364059e-01 0.2430466011 3 141559894 141559995 102 + 1.162 1.021 -0.509
ENSG00000155903 E013 24.3749299 0.0049255640 5.352694e-01 0.6671495778 3 141570912 141571068 157 + 1.235 1.209 -0.093
ENSG00000155903 E014 23.4295462 0.0019410180 4.592443e-01 0.5994712061 3 141571406 141571554 149 + 1.221 1.183 -0.135
ENSG00000155903 E015 21.4388794 0.0009453853 7.072042e-01 0.8051786865 3 141572609 141572723 115 + 1.181 1.183 0.006
ENSG00000155903 E016 16.0388004 0.0010853644 4.592252e-01 0.5994587193 3 141573147 141573221 75 + 1.073 1.021 -0.190
ENSG00000155903 E017 19.9264092 0.0009920384 7.022452e-01 0.8010973736 3 141573944 141574067 124 + 1.155 1.155 0.000
ENSG00000155903 E018 18.9767723 0.0010324133 6.334222e-01 0.7481385453 3 141577000 141577106 107 + 1.137 1.125 -0.045
ENSG00000155903 E019 0.1515154 0.0438924349 7.196245e-01   3 141578524 141578712 189 + 0.046 0.000 -8.627
ENSG00000155903 E020 0.1515154 0.0438924349 7.196245e-01   3 141578713 141578736 24 + 0.046 0.000 -8.627
ENSG00000155903 E021 0.0000000       3 141578737 141578754 18 +      
ENSG00000155903 E022 0.0000000       3 141578755 141578820 66 +      
ENSG00000155903 E023 0.2924217 0.0274086342 1.000000e+00   3 141579437 141579489 53 + 0.087 0.000 -9.638
ENSG00000155903 E024 19.3359913 0.0010074715 2.599391e-01 0.3974261970 3 141580368 141580451 84 + 1.151 1.058 -0.335
ENSG00000155903 E025 14.9374074 0.0014395549 4.072800e-01 0.5508648042 3 141581100 141581177 78 + 1.047 0.979 -0.250
ENSG00000155903 E026 14.8823612 0.0011852297 4.092120e-01 0.5528221640 3 141586025 141586098 74 + 1.016 1.155 0.503
ENSG00000155903 E027 12.3083617 0.0033650541 3.086426e-02 0.0736527109 3 141586646 141586698 53 + 0.911 1.209 1.088
ENSG00000155903 E028 14.9010345 0.0120714337 6.616415e-02 0.1369841657 3 141586699 141586752 54 + 0.997 1.256 0.933
ENSG00000155903 E029 5.3339842 0.0542956765 3.362409e-03 0.0113288457 3 141586753 141586755 3 + 0.552 1.087 2.129
ENSG00000155903 E030 0.2924217 0.0274086342 1.000000e+00   3 141590130 141590141 12 + 0.087 0.000 -9.638
ENSG00000155903 E031 14.5153470 0.0527340475 9.654511e-02 0.1851795131 3 141607678 141607760 83 + 1.052 0.760 -1.109
ENSG00000155903 E032 22.7032282 0.0209365398 3.770901e-01 0.5214229497 3 141608489 141608697 209 + 1.212 1.127 -0.302
ENSG00000155903 E033 15.6294058 0.0011317825 5.493446e-01 0.6790797268 3 141609420 141609523 104 + 1.056 1.021 -0.129
ENSG00000155903 E034 21.9145970 0.0008678100 5.506118e-02 0.1181026028 3 141609877 141610066 190 + 1.209 1.021 -0.677
ENSG00000155903 E035 202.8853094 0.0084438462 2.079149e-05 0.0001284573 3 141612283 141615344 3062 + 2.098 2.313 0.719