ENSG00000155846

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309241 ENSG00000155846 HEK293_OSMI2_2hA HEK293_TMG_2hB PPARGC1B protein_coding protein_coding 4.422471 3.774702 4.083767 0.07120145 0.1461252 0.1132491 0.7959254 0.3539561 1.3063830 0.35395611 0.02493447 1.8547429 0.1853750 0.09736667 0.3211333 0.22376667 1.483760e-01 2.745837e-09 FALSE TRUE
ENST00000360453 ENSG00000155846 HEK293_OSMI2_2hA HEK293_TMG_2hB PPARGC1B protein_coding protein_coding 4.422471 3.774702 4.083767 0.07120145 0.1461252 0.1132491 1.1081077 0.9661254 1.2682077 0.25907467 0.20495012 0.3889838 0.2563792 0.25383333 0.3078000 0.05396667 7.595172e-01 2.745837e-09 FALSE TRUE
ENST00000394320 ENSG00000155846 HEK293_OSMI2_2hA HEK293_TMG_2hB PPARGC1B protein_coding protein_coding 4.422471 3.774702 4.083767 0.07120145 0.1461252 0.1132491 0.5688813 0.3052123 0.4431161 0.01671801 0.06699727 0.5235569 0.1275583 0.08080000 0.1096333 0.02883333 6.590389e-01 2.745837e-09 FALSE TRUE
ENST00000492495 ENSG00000155846 HEK293_OSMI2_2hA HEK293_TMG_2hB PPARGC1B protein_coding retained_intron 4.422471 3.774702 4.083767 0.07120145 0.1461252 0.1132491 1.5273294 2.0292566 0.7368523 0.17343852 0.01163751 -1.4491485 0.3360167 0.53650000 0.1807333 -0.35576667 2.745837e-09 2.745837e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155846 E001 0.2924217 0.0290785164 2.118527e-01   5 149730229 149730297 69 + 0.198 0.000 -10.869
ENSG00000155846 E002 0.2924217 0.0290785164 2.118527e-01   5 149730298 149730300 3 + 0.198 0.000 -12.820
ENSG00000155846 E003 0.2924217 0.0290785164 2.118527e-01   5 149730301 149730302 2 + 0.198 0.000 -12.820
ENSG00000155846 E004 0.5891098 0.0184357100 4.065376e-02 9.223411e-02 5 149730303 149730309 7 + 0.334 0.000 -13.899
ENSG00000155846 E005 7.7030678 0.0022371423 5.054344e-04 2.180616e-03 5 149730310 149730420 111 + 1.068 0.732 -1.282
ENSG00000155846 E006 0.4375944 0.0264058024 9.109773e-02 1.768583e-01 5 149739993 149740125 133 + 0.271 0.000 -13.412
ENSG00000155846 E007 0.1515154 0.0430796144 5.070802e-01   5 149761432 149761612 181 + 0.110 0.000 -11.705
ENSG00000155846 E008 0.0000000       5 149771940 149772139 200 +      
ENSG00000155846 E009 0.4502799 0.0312389191 9.153791e-02 1.775326e-01 5 149817613 149817746 134 + 0.271 0.000 -13.362
ENSG00000155846 E010 16.5713842 0.0039930527 1.162544e-02 3.263981e-02 5 149820433 149820606 174 + 1.303 1.164 -0.490
ENSG00000155846 E011 18.6895311 0.0202366426 1.771029e-01 2.974644e-01 5 149826673 149826885 213 + 1.315 1.257 -0.202
ENSG00000155846 E012 9.2061547 0.0964470560 3.137096e-01 4.563287e-01 5 149830767 149830883 117 + 1.034 0.957 -0.284
ENSG00000155846 E013 27.4136118 0.0147591519 3.907288e-02 8.933107e-02 5 149832656 149833014 359 + 1.496 1.398 -0.338
ENSG00000155846 E014 40.7949219 0.0047060645 3.139051e-04 1.436434e-03 5 149833015 149833583 569 + 1.682 1.541 -0.482
ENSG00000155846 E015 22.5032437 0.0465783520 2.716198e-01 4.103931e-01 5 149833584 149833778 195 + 1.394 1.334 -0.209
ENSG00000155846 E016 10.4564921 0.0019276932 8.225083e-01 8.880864e-01 5 149834674 149834710 37 + 1.023 1.079 0.206
ENSG00000155846 E017 17.7166644 0.0010957783 1.835966e-01 3.057205e-01 5 149835301 149835365 65 + 1.277 1.252 -0.088
ENSG00000155846 E018 76.5572731 0.0003789288 2.029734e-07 1.942645e-06 5 149836263 149837073 811 + 1.942 1.821 -0.405
ENSG00000155846 E019 19.5124213 0.0241939633 1.091713e-01 2.043188e-01 5 149840041 149840116 76 + 1.344 1.258 -0.302
ENSG00000155846 E020 22.1938791 0.0008501673 3.307325e-01 4.743191e-01 5 149842256 149842377 122 + 1.356 1.368 0.045
ENSG00000155846 E021 0.1472490 0.0428228874 5.077752e-01   5 149845643 149845759 117 + 0.110 0.000 -11.707
ENSG00000155846 E022 25.2653966 0.0007931627 9.623805e-02 1.847290e-01 5 149845760 149845914 155 + 1.315 1.512 0.681
ENSG00000155846 E023 15.3739744 0.0012835108 1.791114e-01 3.000320e-01 5 149845915 149847291 1377 + 1.228 1.195 -0.117
ENSG00000155846 E024 5.2099849 0.0039381541 5.277247e-01 6.607528e-01 5 149847292 149847457 166 + 0.703 0.859 0.623
ENSG00000155846 E025 817.7446638 0.0071575587 4.737553e-06 3.390944e-05 5 149847458 149855022 7565 + 2.833 2.984 0.503