ENSG00000155827

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374819 ENSG00000155827 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF20 protein_coding protein_coding 20.46384 12.14923 27.64557 1.384779 0.7456962 1.185519 1.064115 0.00000 2.353799 0.000000 1.5722121 7.884964 0.0358000 0.0000 0.08223333 0.08223333 0.28724824 0.02163827 FALSE  
ENST00000389120 ENSG00000155827 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF20 protein_coding protein_coding 20.46384 12.14923 27.64557 1.384779 0.7456962 1.185519 19.086960 12.10185 24.922450 1.361367 0.7528023 1.041605 0.9484292 0.9965 0.90426667 -0.09223333 0.02163827 0.02163827 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155827 E001 18.6420151 0.0010114926 8.077796e-02 1.607557e-01 9 101533853 101533887 35 + 1.314 1.210 -0.368
ENSG00000155827 E002 29.0796162 0.0006913202 3.089297e-02 7.370962e-02 9 101533888 101533904 17 + 1.499 1.394 -0.363
ENSG00000155827 E003 42.8316676 0.0045077594 4.215911e-05 2.417055e-04 9 101533905 101533914 10 + 1.697 1.462 -0.802
ENSG00000155827 E004 0.1515154 0.0435604861 1.000000e+00   9 101533915 101533957 43 + 0.087 0.000 -9.167
ENSG00000155827 E005 0.1515154 0.0435604861 1.000000e+00   9 101533958 101533968 11 + 0.087 0.000 -9.167
ENSG00000155827 E006 0.0000000       9 101533969 101533978 10 +      
ENSG00000155827 E007 1.3641904 0.0111585271 1.155240e-01 2.136000e-01 9 101533979 101534300 322 + 0.445 0.169 -1.908
ENSG00000155827 E008 105.4889871 0.0005060202 1.175568e-08 1.431080e-07 9 101535398 101535552 155 + 2.067 1.892 -0.588
ENSG00000155827 E009 0.0000000       9 101540177 101540202 26 +      
ENSG00000155827 E010 146.6594195 0.0004074360 1.615644e-14 5.170253e-13 9 101540203 101540370 168 + 2.218 2.009 -0.700
ENSG00000155827 E011 124.7318534 0.0004459163 8.919278e-13 2.208509e-11 9 101540490 101540637 148 + 2.149 1.937 -0.709
ENSG00000155827 E012 137.7169453 0.0057751540 9.898961e-06 6.586802e-05 9 101540793 101540975 183 + 2.182 2.000 -0.608
ENSG00000155827 E013 109.6479745 0.0072866304 1.531077e-03 5.736904e-03 9 101544767 101544885 119 + 2.072 1.932 -0.470
ENSG00000155827 E014 141.8814917 0.0100076451 2.625890e-02 6.446963e-02 9 101546820 101546966 147 + 2.169 2.074 -0.317
ENSG00000155827 E015 117.5160459 0.0005437635 2.747554e-04 1.276995e-03 9 101547137 101547214 78 + 2.087 1.999 -0.293
ENSG00000155827 E016 121.4549696 0.0002827977 6.931823e-02 1.422288e-01 9 101547399 101547518 120 + 2.079 2.061 -0.060
ENSG00000155827 E017 133.5830814 0.0002628526 4.516700e-02 1.004999e-01 9 101550606 101550785 180 + 2.122 2.102 -0.069
ENSG00000155827 E018 133.3784015 0.0007901989 1.629386e-01 2.789786e-01 9 101551684 101551819 136 + 2.116 2.111 -0.015
ENSG00000155827 E019 133.0092482 0.0010850915 1.439011e-02 3.911001e-02 9 101552141 101552262 122 + 2.127 2.083 -0.148
ENSG00000155827 E020 296.9192042 0.0002031855 1.059731e-03 4.165464e-03 9 101552383 101552753 371 + 2.469 2.442 -0.090
ENSG00000155827 E021 153.8887233 0.0003534439 4.061039e-01 5.497568e-01 9 101553988 101554105 118 + 2.149 2.217 0.227
ENSG00000155827 E022 180.0333283 0.0001942515 7.217775e-02 1.469644e-01 9 101554694 101554843 150 + 2.210 2.302 0.307
ENSG00000155827 E023 204.8537032 0.0002097112 3.794721e-01 5.237418e-01 9 101557384 101557596 213 + 2.277 2.343 0.221
ENSG00000155827 E024 0.9555373 0.0134367801 1.457282e-02 3.952833e-02 9 101560681 101560800 120 + 0.087 0.528 3.411
ENSG00000155827 E025 148.2521197 0.0002580292 4.670208e-02 1.033015e-01 9 101560801 101560926 126 + 2.122 2.224 0.344
ENSG00000155827 E026 155.0306045 0.0002178938 3.846599e-02 8.822249e-02 9 101561090 101561230 141 + 2.140 2.244 0.346
ENSG00000155827 E027 0.1515154 0.0435604861 1.000000e+00   9 101561231 101561452 222 + 0.087 0.000 -9.167
ENSG00000155827 E028 146.8072041 0.0002613512 1.508599e-06 1.205702e-05 9 101561910 101562011 102 + 2.081 2.266 0.620
ENSG00000155827 E029 588.6553822 0.0078234268 1.069074e-12 2.609288e-11 9 101562246 101563344 1099 + 2.611 2.931 1.066