ENSG00000155744

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418596 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding protein_coding 3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 1.600791620 0.19443442 3.2358113 0.11804045 0.19786162 3.9888691 0.487333333 0.29086667 0.44686667 0.15600000 6.711081e-01 7.545499e-09 FALSE TRUE
ENST00000446678 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding protein_coding 3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 0.074023400 0.13575110 0.1572941 0.13575110 0.09262567 0.1988799 0.058662500 0.12236667 0.02153333 -0.10083333 8.620971e-01 7.545499e-09   FALSE
ENST00000485636 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding retained_intron 3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 0.004371911 0.03497529 0.0000000 0.03497529 0.00000000 -2.1691325 0.006720833 0.05376667 0.00000000 -0.05376667 3.138754e-01 7.545499e-09   FALSE
ENST00000681958 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding protein_coding 3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 0.590679806 0.20331631 0.9485665 0.14178941 0.22921789 2.1678843 0.151720833 0.21160000 0.12886667 -0.08273333 8.237769e-01 7.545499e-09 FALSE TRUE
MSTRG.19748.4 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding   3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 0.918231064 0.00000000 2.1260565 0.00000000 0.07936633 7.7388060 0.146895833 0.00000000 0.29233333 0.29233333 7.545499e-09 7.545499e-09 FALSE TRUE
MSTRG.19748.5 ENSG00000155744 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126B protein_coding   3.679135 0.8121456 7.280324 0.1487989 0.311645 3.148517 0.151426003 0.13247086 0.4919667 0.04924920 0.27941579 1.8169247 0.058933333 0.18780000 0.06830000 -0.11950000 6.162263e-01 7.545499e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155744 E001 269.2969691 0.0012469704 4.060475e-06 2.948654e-05 2 200973718 200978492 4775 - 2.202 2.347 0.484
ENSG00000155744 E002 98.1357535 0.0003089906 1.004696e-03 3.974844e-03 2 200978493 200980454 1962 - 1.803 1.611 -0.650
ENSG00000155744 E003 108.3955071 0.0003426672 7.836462e-05 4.202673e-04 2 200980455 200981620 1166 - 1.848 1.622 -0.765
ENSG00000155744 E004 40.3434070 0.0046682788 2.542452e-01 3.908942e-01 2 200981621 200981871 251 - 1.419 1.321 -0.341
ENSG00000155744 E005 6.5637909 0.0311928852 3.597859e-01 5.041111e-01 2 200987365 200987532 168 - 0.684 0.860 0.705
ENSG00000155744 E006 35.1276035 0.0006754222 9.520774e-03 2.758978e-02 2 200988262 200988421 160 - 1.373 1.098 -0.972
ENSG00000155744 E007 22.7579348 0.0053837649 3.842977e-02 8.815757e-02 2 200992281 200992368 88 - 1.197 0.921 -1.006
ENSG00000155744 E008 24.6740485 0.0008025631 8.014204e-02 1.597638e-01 2 200992887 200993003 117 - 1.224 1.019 -0.739
ENSG00000155744 E009 0.7394768 0.0184369552 2.296367e-05 1.403762e-04 2 200996050 200997444 1395 - 0.000 0.716 15.817
ENSG00000155744 E010 23.4314356 0.0008808362 2.217678e-01 3.524985e-01 2 200997445 200997540 96 - 1.197 1.060 -0.492
ENSG00000155744 E011 23.8476645 0.0291372345 2.763409e-02 6.728091e-02 2 201008973 201009088 116 - 1.221 0.861 -1.318
ENSG00000155744 E012 1.0865305 0.3668498410 5.586817e-01 6.868915e-01 2 201009089 201009452 364 - 0.207 0.312 0.785
ENSG00000155744 E013 19.4692011 0.0009722622 2.084073e-01 3.365625e-01 2 201011392 201011472 81 - 1.128 0.972 -0.567
ENSG00000155744 E014 15.6287815 0.0012925653 8.519537e-01 9.082249e-01 2 201016991 201017061 71 - 1.029 1.018 -0.040
ENSG00000155744 E015 15.2705681 0.0019049039 9.252697e-01 9.569566e-01 2 201017062 201017126 65 - 1.017 1.018 0.006
ENSG00000155744 E016 13.4518194 0.0057599514 4.090219e-01 5.526250e-01 2 201017127 201017170 44 - 0.977 0.862 -0.433
ENSG00000155744 E017 0.7511326 0.4469810658 1.413375e-01 2.498667e-01 2 201021448 201021875 428 - 0.116 0.479 2.722
ENSG00000155744 E018 3.0613695 0.0053636698 1.462832e-04 7.310955e-04 2 201022059 201022114 56 - 0.324 0.973 2.917
ENSG00000155744 E019 0.0000000       2 201022481 201022545 65 -      
ENSG00000155744 E020 0.1817044 0.0510390269 2.703658e-02   2 201022546 201022830 285 - 0.000 0.312 13.200
ENSG00000155744 E021 18.6314170 0.0082153171 1.857478e-02 4.839487e-02 2 201022831 201022932 102 - 1.057 1.340 1.006
ENSG00000155744 E022 0.1472490 0.0453143298 5.721333e-01   2 201023616 201023958 343 - 0.042 0.000 -9.747
ENSG00000155744 E023 17.3381786 0.0010701115 2.407772e-02 5.997174e-02 2 201023959 201024039 81 - 1.033 1.298 0.945
ENSG00000155744 E024 15.3997273 0.0011934087 3.002107e-02 7.199902e-02 2 201045496 201045593 98 - 0.982 1.250 0.966
ENSG00000155744 E025 0.2987644 0.0276820787 1.000000e+00   2 201052173 201052269 97 - 0.080 0.000 -10.945
ENSG00000155744 E026 0.3289534 0.0348704264 9.619522e-02   2 201061307 201061424 118 - 0.042 0.312 3.377
ENSG00000155744 E027 4.1705804 0.0183397854 7.799841e-01 8.585537e-01 2 201071454 201071488 35 - 0.547 0.617 0.315
ENSG00000155744 E028 4.3157531 0.0116189348 8.228909e-01 8.883367e-01 2 201071489 201071609 121 - 0.559 0.617 0.259
ENSG00000155744 E029 7.2754306 0.0148811460 1.786344e-03 6.555584e-03 2 201071610 201071671 62 - 0.657 1.132 1.827