ENSG00000155621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334731 ENSG00000155621 HEK293_OSMI2_2hA HEK293_TMG_2hB C9orf85 protein_coding protein_coding 8.941157 5.80318 10.91064 0.322318 0.8436189 0.9096579 4.7159514 2.5952352 6.3366173 0.18388905 0.20415441 1.2845742 0.49113750 0.44820000 0.58513333 0.1369333 7.794962e-02 1.629373e-05 FALSE TRUE
ENST00000377031 ENSG00000155621 HEK293_OSMI2_2hA HEK293_TMG_2hB C9orf85 protein_coding protein_coding 8.941157 5.80318 10.91064 0.322318 0.8436189 0.9096579 1.1889970 1.1166700 0.8637108 0.15448487 0.07934491 -0.3668373 0.14942917 0.19280000 0.07946667 -0.1133333 1.555692e-03 1.629373e-05 FALSE TRUE
ENST00000479413 ENSG00000155621 HEK293_OSMI2_2hA HEK293_TMG_2hB C9orf85 protein_coding nonsense_mediated_decay 8.941157 5.80318 10.91064 0.322318 0.8436189 0.9096579 0.9572992 0.2359608 1.2875911 0.09557619 0.31340778 2.3993354 0.10809583 0.04026667 0.11546667 0.0752000 9.789442e-02 1.629373e-05   FALSE
MSTRG.32861.3 ENSG00000155621 HEK293_OSMI2_2hA HEK293_TMG_2hB C9orf85 protein_coding   8.941157 5.80318 10.91064 0.322318 0.8436189 0.9096579 1.0327433 1.2513913 0.7823264 0.17594317 0.07969065 -0.6708491 0.14385000 0.21496667 0.07190000 -0.1430667 1.629373e-05 1.629373e-05   FALSE
MSTRG.32861.7 ENSG00000155621 HEK293_OSMI2_2hA HEK293_TMG_2hB C9orf85 protein_coding   8.941157 5.80318 10.91064 0.322318 0.8436189 0.9096579 0.4774615 0.1461072 0.8957162 0.07928208 0.14400299 2.5365223 0.04536667 0.02536667 0.08126667 0.0559000 1.760147e-01 1.629373e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155621 E001 2.190551 0.0071905096 1.318341e-01 2.366748e-01 9 71911510 71911544 35 + 0.581 0.351 -1.176
ENSG00000155621 E002 4.923069 0.0037006582 8.710731e-02 1.707579e-01 9 71911545 71911634 90 + 0.837 0.635 -0.824
ENSG00000155621 E003 2.850635 0.0053145938 2.602456e-01 3.977248e-01 9 71911635 71911638 4 + 0.636 0.488 -0.680
ENSG00000155621 E004 2.523758 0.0063447165 1.934618e-01 3.181241e-01 9 71911639 71911640 2 + 0.609 0.425 -0.886
ENSG00000155621 E005 4.446639 0.0111012628 9.246417e-02 1.789683e-01 9 71911641 71911650 10 + 0.804 0.592 -0.885
ENSG00000155621 E006 10.309338 0.0017592462 1.643115e-01 2.807870e-01 9 71911651 71911660 10 + 1.088 0.987 -0.368
ENSG00000155621 E007 55.422589 0.0004371442 1.463103e-01 2.566584e-01 9 71911661 71911801 141 + 1.755 1.736 -0.065
ENSG00000155621 E008 39.102146 0.0005756979 2.750974e-01 4.143488e-01 9 71911802 71911836 35 + 1.606 1.593 -0.045
ENSG00000155621 E009 2.250828 0.0068619369 4.879615e-01 6.255936e-01 9 71918425 71918555 131 + 0.445 0.591 0.698
ENSG00000155621 E010 7.128937 0.0023127049 2.408998e-03 8.488906e-03 9 71941805 71941934 130 + 1.019 0.675 -1.341
ENSG00000155621 E011 52.085162 0.0005344505 2.666246e-03 9.271348e-03 9 71947006 71947112 107 + 1.757 1.661 -0.328
ENSG00000155621 E012 53.382969 0.0012114627 4.536169e-03 1.464317e-02 9 71971505 71971618 114 + 1.765 1.673 -0.313
ENSG00000155621 E013 94.115936 0.0006778728 1.580630e-06 1.256854e-05 9 71972692 71973457 766 + 2.020 1.900 -0.404
ENSG00000155621 E014 26.809743 0.0008090143 9.930321e-12 2.069831e-10 9 71982657 71983016 360 + 1.163 1.660 1.725
ENSG00000155621 E015 86.726671 0.0144082107 1.453182e-09 2.089254e-08 9 71983017 71986054 3038 + 1.721 2.128 1.369