ENSG00000155545

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336942 ENSG00000155545 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER3 protein_coding protein_coding 9.282735 1.07575 18.7783 0.1698816 0.9070203 4.113071 0.9678744 0.0000000 3.803312 0.0000000 0.8030599 8.574901 0.05290833 0.0000 0.20170000 0.20170000 4.468975e-05 4.468975e-05 FALSE FALSE
ENST00000381199 ENSG00000155545 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER3 protein_coding protein_coding 9.282735 1.07575 18.7783 0.1698816 0.9070203 4.113071 4.5531496 0.8599257 7.700342 0.2647378 0.9566717 3.147831 0.59361667 0.7809 0.40800000 -0.37290000 1.703506e-01 4.468975e-05 FALSE TRUE
ENST00000381213 ENSG00000155545 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER3 protein_coding protein_coding 9.282735 1.07575 18.7783 0.1698816 0.9070203 4.113071 1.9203228 0.1733101 3.753666 0.1733101 0.4594062 4.359781 0.22712917 0.1691 0.20320000 0.03410000 5.268663e-01 4.468975e-05 FALSE TRUE
MSTRG.26226.6 ENSG00000155545 HEK293_OSMI2_2hA HEK293_TMG_2hB MIER3 protein_coding   9.282735 1.07575 18.7783 0.1698816 0.9070203 4.113071 1.0645011 0.0000000 1.561109 0.0000000 0.4399003 7.295640 0.06288750 0.0000 0.08266667 0.08266667 1.269275e-02 4.468975e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155545 E001 0.0000000       5 56919602 56919602 1 -      
ENSG00000155545 E002 0.2934659 0.0284628146 5.706117e-02   5 56919603 56919603 1 - 0.027 0.421 4.665
ENSG00000155545 E003 457.1063582 0.0357438454 6.487808e-09 8.287343e-08 5 56919604 56922583 2980 - 2.230 2.810 1.933
ENSG00000155545 E004 207.4704195 0.0014138491 7.931824e-05 4.246722e-04 5 56922584 56923585 1002 - 1.940 1.968 0.093
ENSG00000155545 E005 67.4830331 0.0003816179 2.206533e-01 3.512015e-01 5 56923691 56923833 143 - 1.456 1.588 0.453
ENSG00000155545 E006 54.5276136 0.0004662287 3.200252e-01 4.631224e-01 5 56923915 56924042 128 - 1.366 1.507 0.489
ENSG00000155545 E007 48.0731036 0.0113102835 5.338035e-02 1.151702e-01 5 56928767 56928858 92 - 1.322 1.317 -0.018
ENSG00000155545 E008 23.0559843 0.0054659893 3.053319e-02 7.301535e-02 5 56928859 56928861 3 - 1.031 0.879 -0.570
ENSG00000155545 E009 51.9134771 0.0023301893 2.738925e-03 9.489588e-03 5 56930664 56930745 82 - 1.358 1.241 -0.410
ENSG00000155545 E010 70.9457172 0.0030355084 1.236944e-04 6.307476e-04 5 56933247 56933398 152 - 1.491 1.316 -0.604
ENSG00000155545 E011 50.5254340 0.0042162451 1.124007e-02 3.173875e-02 5 56935428 56935500 73 - 1.345 1.280 -0.226
ENSG00000155545 E012 36.9762090 0.0075385262 2.123831e-01 3.413362e-01 5 56935666 56935670 5 - 1.211 1.280 0.244
ENSG00000155545 E013 59.6603249 0.0004410372 9.107666e-02 1.768247e-01 5 56935671 56935743 73 - 1.408 1.485 0.263
ENSG00000155545 E014 35.9325372 0.0005459587 2.036862e-01 3.308135e-01 5 56935744 56935751 8 - 1.200 1.280 0.281
ENSG00000155545 E015 0.0000000       5 56936894 56936936 43 -      
ENSG00000155545 E016 76.2646351 0.0003565424 1.258374e-03 4.837662e-03 5 56937578 56937698 121 - 1.518 1.461 -0.197
ENSG00000155545 E017 2.8199563 0.0897172449 9.071058e-01 9.450210e-01 5 56938296 56938338 43 - 0.334 0.422 0.503
ENSG00000155545 E018 0.2944980 0.4810330328 6.704802e-01   5 56938814 56938882 69 - 0.053 0.000 -6.880
ENSG00000155545 E019 82.2590865 0.0035761067 1.182527e-04 6.058363e-04 5 56938883 56939017 135 - 1.552 1.409 -0.491
ENSG00000155545 E020 0.5891098 0.0183067588 1.000000e+00 1.000000e+00 5 56940999 56941133 135 - 0.100 0.001 -7.454
ENSG00000155545 E021 63.5739051 0.0007285870 5.376542e-04 2.300916e-03 5 56946926 56947030 105 - 1.444 1.316 -0.445
ENSG00000155545 E022 35.4707761 0.0006239166 3.520467e-04 1.588340e-03 5 56947031 56947031 1 - 1.209 0.879 -1.210
ENSG00000155545 E023 39.0201969 0.0005620044 9.405400e-05 4.940182e-04 5 56947032 56947071 40 - 1.249 0.879 -1.350
ENSG00000155545 E024 0.1515154 0.0436793866 4.215490e-01   5 56947072 56947086 15 - 0.027 0.001 -5.565
ENSG00000155545 E025 1.1824861 0.0112209317 1.000000e+00 1.000000e+00 5 56950571 56950627 57 - 0.181 0.001 -8.405
ENSG00000155545 E026 27.2760545 0.0007466784 2.695377e-04 1.255701e-03 5 56950628 56950652 25 - 1.106 0.631 -1.841
ENSG00000155545 E027 13.6599806 0.0012938036 1.027670e-02 2.944836e-02 5 56952094 56952110 17 - 0.837 0.422 -1.841
ENSG00000155545 E028 5.0651267 0.0032554926 3.582349e-01 5.026033e-01 5 56952111 56952203 93 - 0.496 0.422 -0.377
ENSG00000155545 E029 1.4758382 0.0090136724 6.703374e-01 7.768131e-01 5 56952349 56952625 277 - 0.199 0.421 1.496
ENSG00000155545 E030 0.0000000       5 56959386 56959520 135 -      
ENSG00000155545 E031 0.0000000       5 56971633 56971675 43 -