ENSG00000155508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285896 ENSG00000155508 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT8 protein_coding protein_coding 28.1184 18.83211 36.58838 2.214097 0.5891914 0.9578196 17.9214856 11.6886967 24.273052 1.4323276 1.3274179 1.0536020 0.63966667 0.62043333 0.6626 0.04216667 6.239531e-01 2.72103e-16 FALSE  
ENST00000403027 ENSG00000155508 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT8 protein_coding protein_coding 28.1184 18.83211 36.58838 2.214097 0.5891914 0.9578196 1.8469593 0.9770518 1.089780 0.5624202 0.5456760 0.1560177 0.06646250 0.04733333 0.0295 -0.01783333 9.464510e-01 2.72103e-16 FALSE  
ENST00000520671 ENSG00000155508 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT8 protein_coding protein_coding 28.1184 18.83211 36.58838 2.214097 0.5891914 0.9578196 0.7254601 1.4508052 0.000000 0.7841741 0.0000000 -7.1906200 0.02938333 0.07140000 0.0000 -0.07140000 8.247481e-02 2.72103e-16 FALSE  
MSTRG.27218.9 ENSG00000155508 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT8 protein_coding   28.1184 18.83211 36.58838 2.214097 0.5891914 0.9578196 1.0024441 0.0000000 2.867413 0.0000000 0.4159565 8.1686287 0.03026250 0.00000000 0.0786 0.07860000 2.721030e-16 2.72103e-16 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155508 E001 3.1676406 0.0051389459 0.0016620488 0.0061601550 5 154824029 154824092 64 + 0.342 0.856 2.366
ENSG00000155508 E002 0.3289534 0.0269772277 0.7065545457   5 154857553 154857893 341 + 0.093 0.159 0.882
ENSG00000155508 E003 1.1112941 0.0693183829 0.8004259947 0.8727836459 5 154858219 154858240 22 + 0.292 0.366 0.462
ENSG00000155508 E004 1.6616927 0.1066687930 0.4575491793 0.5978764217 5 154858241 154858248 8 + 0.342 0.507 0.887
ENSG00000155508 E005 2.1400852 0.0085557195 0.5323555223 0.6647364973 5 154858249 154858251 3 + 0.428 0.562 0.660
ENSG00000155508 E006 2.6570726 0.0213697113 0.3310727749 0.4746700671 5 154858252 154858256 5 + 0.465 0.657 0.884
ENSG00000155508 E007 4.6519745 0.0723210032 0.9089484494 0.9461612173 5 154858257 154858261 5 + 0.725 0.768 0.173
ENSG00000155508 E008 8.5271344 0.0076580915 0.8244195143 0.8893939520 5 154858262 154858350 89 + 0.961 0.973 0.044
ENSG00000155508 E009 13.1608059 0.0014399283 0.0872770733 0.1710040305 5 154858351 154858481 131 + 1.187 1.064 -0.440
ENSG00000155508 E010 7.2258452 0.0026707676 0.3215898973 0.4648469917 5 154858482 154858514 33 + 0.938 0.856 -0.311
ENSG00000155508 E011 6.1885319 0.0027765930 0.8350136039 0.8967552000 5 154858515 154858516 2 + 0.845 0.856 0.045
ENSG00000155508 E012 6.4872963 0.0026448565 0.6566586688 0.7661685102 5 154858517 154858525 9 + 0.873 0.856 -0.066
ENSG00000155508 E013 1.2491936 0.0121323081 0.4578669536 0.5981885065 5 154858526 154858536 11 + 0.387 0.275 -0.703
ENSG00000155508 E014 1.0277484 0.0141804264 0.1790596254 0.2999585185 5 154858537 154858538 2 + 0.387 0.159 -1.704
ENSG00000155508 E015 1.1729211 0.0148963556 0.1192610771 0.2188904492 5 154858539 154858543 5 + 0.428 0.159 -1.926
ENSG00000155508 E016 4.8576534 0.0032464750 0.8983884783 0.9392044878 5 154858544 154858624 81 + 0.745 0.799 0.218
ENSG00000155508 E017 4.7124807 0.0035325275 0.7889245434 0.8648899607 5 154858625 154858626 2 + 0.726 0.799 0.296
ENSG00000155508 E018 7.0471607 0.0023169812 0.3724971325 0.5169564929 5 154858627 154858634 8 + 0.926 0.856 -0.265
ENSG00000155508 E019 6.7483963 0.0024212030 0.5007645388 0.6369909729 5 154858635 154858638 4 + 0.900 0.856 -0.169
ENSG00000155508 E020 17.1869266 0.0010389148 0.2144656023 0.3438284572 5 154858639 154858651 13 + 1.278 1.216 -0.218
ENSG00000155508 E021 15.4112678 0.0011597191 0.2282439992 0.3603285022 5 154858652 154858653 2 + 1.232 1.167 -0.230
ENSG00000155508 E022 25.2283239 0.0007932722 0.0782862360 0.1567222064 5 154858654 154858661 8 + 1.445 1.363 -0.282
ENSG00000155508 E023 45.4343040 0.0005697879 0.0021451283 0.0076756656 5 154858662 154858688 27 + 1.704 1.581 -0.420
ENSG00000155508 E024 83.8949397 0.0014058517 0.0078681924 0.0234494955 5 154858689 154858768 80 + 1.948 1.876 -0.243
ENSG00000155508 E025 24.1558171 0.0021855754 0.0100041956 0.0287730647 5 154858769 154858797 29 + 1.445 1.291 -0.534
ENSG00000155508 E026 19.5831244 0.0043896765 0.0022079034 0.0078667071 5 154858798 154858801 4 + 1.381 1.154 -0.797
ENSG00000155508 E027 15.2466230 0.0316904942 0.0210189560 0.0536293354 5 154858802 154858816 15 + 1.285 1.030 -0.911
ENSG00000155508 E028 2.7483144 0.0194799018 0.0021672926 0.0077419594 5 154858817 154858833 17 + 0.706 0.159 -3.204
ENSG00000155508 E029 7.1801205 0.0024086998 0.0001213386 0.0006200197 5 154859353 154859404 52 + 1.044 0.562 -1.926
ENSG00000155508 E030 8.1422135 0.0022418240 0.0217306503 0.0551178389 5 154859405 154859496 92 + 1.035 0.799 -0.892
ENSG00000155508 E031 3.0312849 0.0050049156 0.0056027893 0.0175605342 5 154859667 154859694 28 + 0.726 0.275 -2.288
ENSG00000155508 E032 4.0767993 0.0125057624 0.2694961768 0.4080045567 5 154859695 154859837 143 + 0.745 0.612 -0.560
ENSG00000155508 E033 1.6347405 0.0087469643 0.1642901970 0.2807530665 5 154859838 154859873 36 + 0.499 0.275 -1.290
ENSG00000155508 E034 51.5381551 0.0004394689 0.0088736974 0.0259644666 5 154863207 154863211 5 + 1.747 1.659 -0.300
ENSG00000155508 E035 184.3649895 0.0002707390 0.1012804246 0.1924224538 5 154863212 154863395 184 + 2.263 2.264 0.004
ENSG00000155508 E036 237.7937119 0.0016282316 0.3311516596 0.4747400528 5 154865192 154865385 194 + 2.367 2.380 0.043
ENSG00000155508 E037 3.3745050 0.1105642473 0.6133226924 0.7320313321 5 154867692 154867792 101 + 0.661 0.568 -0.411
ENSG00000155508 E038 1.5272454 0.0542489283 0.2656515451 0.4037135755 5 154870444 154870660 217 + 0.465 0.274 -1.124
ENSG00000155508 E039 216.7396471 0.0024661999 0.2029530996 0.3299113276 5 154870661 154870822 162 + 2.332 2.329 -0.012
ENSG00000155508 E040 218.5997692 0.0012384739 0.8215855918 0.8874737750 5 154871730 154871874 145 + 2.322 2.357 0.118
ENSG00000155508 E041 192.1129949 0.0018567092 0.4931269184 0.6301740697 5 154872541 154872651 111 + 2.253 2.317 0.212
ENSG00000155508 E042 997.7716140 0.0045130279 0.0005804712 0.0024617432 5 154875290 154876792 1503 + 2.942 3.057 0.383