ENSG00000155463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442110 ENSG00000155463 HEK293_OSMI2_2hA HEK293_TMG_2hB OXA1L protein_coding nonsense_mediated_decay 97.62546 128.7087 81.13591 6.061583 0.3475159 -0.6656318 18.099672 20.857286 15.332414 4.42121553 0.6392780 -0.4437175 0.18650000 0.16076667 0.1890333 0.02826667 7.342657e-01 2.381976e-47 FALSE FALSE
ENST00000473744 ENSG00000155463 HEK293_OSMI2_2hA HEK293_TMG_2hB OXA1L protein_coding retained_intron 97.62546 128.7087 81.13591 6.061583 0.3475159 -0.6656318 7.267945 6.070876 8.278171 0.71165939 0.7026362 0.4467745 0.07902917 0.04693333 0.1020333 0.05510000 6.709571e-05 2.381976e-47 FALSE TRUE
ENST00000483939 ENSG00000155463 HEK293_OSMI2_2hA HEK293_TMG_2hB OXA1L protein_coding retained_intron 97.62546 128.7087 81.13591 6.061583 0.3475159 -0.6656318 4.567910 1.770108 6.783457 0.08183169 0.1682835 1.9321810 0.05180417 0.01373333 0.0836000 0.06986667 2.381976e-47 2.381976e-47 FALSE TRUE
ENST00000612549 ENSG00000155463 HEK293_OSMI2_2hA HEK293_TMG_2hB OXA1L protein_coding protein_coding 97.62546 128.7087 81.13591 6.061583 0.3475159 -0.6656318 56.030278 93.110889 35.670338 4.75955059 0.7933594 -1.3839756 0.55482083 0.72450000 0.4396333 -0.28486667 1.271694e-06 2.381976e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155463 E001 0.7393776 0.4656570730 6.429232e-01 7.555964e-01 14 22766522 22766674 153 + 0.300 0.206 -0.715
ENSG00000155463 E002 7.6317094 0.0021301726 1.380091e-03 5.241241e-03 14 22766675 22766687 13 + 1.127 0.771 -1.339
ENSG00000155463 E003 9.3571160 0.0018076221 1.397626e-03 5.299019e-03 14 22766688 22766689 2 + 1.187 0.857 -1.218
ENSG00000155463 E004 12.7818943 0.0013458312 1.233660e-04 6.292593e-04 14 22766690 22766691 2 + 1.319 0.969 -1.254
ENSG00000155463 E005 43.5317535 0.0010331811 1.767588e-04 8.643666e-04 14 22766692 22766701 10 + 1.737 1.535 -0.688
ENSG00000155463 E006 44.4529372 0.0010370716 6.993752e-05 3.797489e-04 14 22766702 22766702 1 + 1.753 1.540 -0.722
ENSG00000155463 E007 127.8323448 0.0002594191 2.706594e-05 1.627437e-04 14 22766703 22766708 6 + 2.152 2.021 -0.440
ENSG00000155463 E008 281.2679045 0.0001529978 1.353221e-01 2.415676e-01 14 22766709 22766718 10 + 2.417 2.390 -0.088
ENSG00000155463 E009 456.1791249 0.0022031082 4.033649e-01 5.471359e-01 14 22766719 22766764 46 + 2.618 2.599 -0.063
ENSG00000155463 E010 20.5279633 0.0440734126 6.155243e-06 4.294208e-05 14 22766765 22766914 150 + 1.605 1.045 -1.958
ENSG00000155463 E011 10.5130252 0.0312703701 1.386885e-05 8.914944e-05 14 22766915 22766924 10 + 1.329 0.777 -2.029
ENSG00000155463 E012 16.3973840 0.0109371896 1.720846e-11 3.446185e-10 14 22766925 22767051 127 + 1.547 0.908 -2.273
ENSG00000155463 E013 541.4458211 0.0025575767 6.679779e-01 7.750934e-01 14 22767248 22767281 34 + 2.685 2.677 -0.025
ENSG00000155463 E014 557.6257214 0.0021341452 1.739284e-01 2.932896e-01 14 22767282 22767317 36 + 2.715 2.684 -0.105
ENSG00000155463 E015 813.8554515 0.0008550736 4.964533e-02 1.085344e-01 14 22767318 22767409 92 + 2.879 2.848 -0.103
ENSG00000155463 E016 19.3238368 0.0011031937 5.389810e-27 6.955609e-25 14 22767410 22767708 299 + 1.687 0.844 -2.995
ENSG00000155463 E017 1277.7517469 0.0014732835 1.339055e-01 2.395783e-01 14 22767958 22768171 214 + 3.070 3.045 -0.084
ENSG00000155463 E018 66.0981663 0.0003774920 1.710549e-87 3.641106e-84 14 22768172 22768929 758 + 2.216 1.336 -2.979
ENSG00000155463 E019 443.3658152 0.0002961127 6.446748e-01 7.569272e-01 14 22769791 22769796 6 + 2.594 2.593 -0.004
ENSG00000155463 E020 1088.5647256 0.0003625115 2.122477e-01 3.411793e-01 14 22769797 22769934 138 + 2.991 2.980 -0.037
ENSG00000155463 E021 1047.2023430 0.0001024575 4.868084e-01 6.245303e-01 14 22770193 22770278 86 + 2.954 2.972 0.058
ENSG00000155463 E022 92.8723888 0.0010703808 8.048570e-33 1.659170e-30 14 22770279 22770460 182 + 2.205 1.743 -1.551
ENSG00000155463 E023 898.0400143 0.0000854687 7.223499e-01 8.164756e-01 14 22770461 22770499 39 + 2.891 2.904 0.045
ENSG00000155463 E024 1057.5846067 0.0001036094 2.111993e-01 3.399228e-01 14 22770500 22770553 54 + 2.954 2.979 0.082
ENSG00000155463 E025 1197.0648043 0.0004225122 1.342203e-01 2.400260e-01 14 22770554 22770625 72 + 3.003 3.033 0.101
ENSG00000155463 E026 658.0282417 0.0006912930 8.544838e-01 9.099767e-01 14 22770805 22770808 4 + 2.757 2.770 0.041
ENSG00000155463 E027 1374.5663151 0.0003476023 1.893091e-01 3.128584e-01 14 22770809 22770909 101 + 3.066 3.092 0.086
ENSG00000155463 E028 1643.3368133 0.0004165563 1.026919e-03 4.051536e-03 14 22771018 22771180 163 + 3.124 3.176 0.170
ENSG00000155463 E029 1128.8457180 0.0015656200 7.877663e-05 4.222140e-04 14 22771268 22771348 81 + 2.927 3.021 0.312
ENSG00000155463 E030 1689.3205699 0.0012115836 5.705938e-06 4.008651e-05 14 22771434 22773042 1609 + 3.105 3.195 0.300