ENSG00000155438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285814 ENSG00000155438 HEK293_OSMI2_2hA HEK293_TMG_2hB NIFK protein_coding protein_coding 71.06453 32.13531 130.5129 3.220517 5.83264 2.021623 38.305007 20.820576 68.180340 1.747491 2.234057 1.710865 0.53795833 0.65083333 0.52370000 -0.12713333 1.615486e-02 8.115882e-19 FALSE TRUE
ENST00000447132 ENSG00000155438 HEK293_OSMI2_2hA HEK293_TMG_2hB NIFK protein_coding protein_coding 71.06453 32.13531 130.5129 3.220517 5.83264 2.021623 14.919625 5.519607 26.834650 1.136746 2.668339 2.279386 0.19268333 0.18233333 0.20463333 0.02230000 8.327407e-01 8.115882e-19 FALSE FALSE
ENST00000451734 ENSG00000155438 HEK293_OSMI2_2hA HEK293_TMG_2hB NIFK protein_coding protein_coding 71.06453 32.13531 130.5129 3.220517 5.83264 2.021623 2.240803 0.000000 7.049018 0.000000 1.267721 9.463324 0.02352917 0.00000000 0.05343333 0.05343333 8.115882e-19 8.115882e-19 FALSE FALSE
ENST00000481978 ENSG00000155438 HEK293_OSMI2_2hA HEK293_TMG_2hB NIFK protein_coding retained_intron 71.06453 32.13531 130.5129 3.220517 5.83264 2.021623 4.616936 1.138300 5.999342 1.138300 3.055396 2.387707 0.08213333 0.02993333 0.04420000 0.01426667 6.266442e-01 8.115882e-19 FALSE TRUE
ENST00000498570 ENSG00000155438 HEK293_OSMI2_2hA HEK293_TMG_2hB NIFK protein_coding retained_intron 71.06453 32.13531 130.5129 3.220517 5.83264 2.021623 7.735757 3.313528 15.386452 1.657023 2.395270 2.211811 0.11593333 0.09616667 0.11930000 0.02313333 8.364281e-01 8.115882e-19 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155438 E001 307.102635 0.0017614799 1.668125e-02 4.423713e-02 2 121726945 121727346 402 - 2.428 2.498 0.236
ENSG00000155438 E002 437.381126 0.0001922628 3.502237e-05 2.047487e-04 2 121727347 121727675 329 - 2.579 2.655 0.255
ENSG00000155438 E003 146.825187 0.0005136323 2.599176e-08 2.963624e-07 2 121727676 121727730 55 - 2.072 2.249 0.594
ENSG00000155438 E004 291.733606 0.0002161561 9.774253e-04 3.882568e-03 2 121727731 121727796 66 - 2.405 2.479 0.249
ENSG00000155438 E005 511.209224 0.0001313047 4.074256e-01 5.509988e-01 2 121727797 121727912 116 - 2.666 2.680 0.046
ENSG00000155438 E006 443.625181 0.0001294471 1.718820e-01 2.906563e-01 2 121728288 121728356 69 - 2.601 2.626 0.082
ENSG00000155438 E007 371.433199 0.0001395118 3.997872e-01 5.435174e-01 2 121728477 121728506 30 - 2.536 2.518 -0.060
ENSG00000155438 E008 350.593847 0.0001437375 4.242567e-01 5.672295e-01 2 121728507 121728536 30 - 2.511 2.493 -0.059
ENSG00000155438 E009 7.977891 0.0020641536 7.708518e-03 2.304709e-02 2 121728537 121728599 63 - 0.798 1.107 1.158
ENSG00000155438 E010 16.691120 0.0010507991 6.450642e-01 7.572623e-01 2 121730383 121730892 510 - 1.196 1.237 0.145
ENSG00000155438 E011 743.799686 0.0004491893 6.684423e-02 1.381280e-01 2 121730893 121731104 212 - 2.840 2.808 -0.108
ENSG00000155438 E012 1.106009 0.0189167964 7.919117e-02 1.582195e-01 2 121731105 121731189 85 - 0.195 0.511 1.985
ENSG00000155438 E013 483.662362 0.0006231011 1.423119e-02 3.875346e-02 2 121732096 121732204 109 - 2.658 2.604 -0.180
ENSG00000155438 E014 300.864337 0.0001989689 3.116729e-03 1.060977e-02 2 121735613 121735654 42 - 2.458 2.387 -0.236
ENSG00000155438 E015 427.392121 0.0001938395 2.314600e-02 5.805100e-02 2 121735655 121735750 96 - 2.603 2.557 -0.153
ENSG00000155438 E016 3.415810 0.0247673725 8.261987e-01 8.906236e-01 2 121735751 121735805 55 - 0.604 0.640 0.154
ENSG00000155438 E017 8.990195 0.0027095871 1.353961e-01 2.416679e-01 2 121736533 121736745 213 - 1.011 0.820 -0.721
ENSG00000155438 E018 365.879507 0.0008172918 1.226923e-04 6.261431e-04 2 121736746 121736911 166 - 2.549 2.450 -0.327