ENSG00000155380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369626 ENSG00000155380 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A1 protein_coding protein_coding 126.1767 48.52653 200.1136 8.850441 4.602468 2.043749 77.446001 6.254369 132.62390 0.9456208 5.181155 4.404137 0.4617667 0.1396333 0.6622667 0.5226333 5.084352e-11 2.400364e-75 FALSE TRUE
ENST00000679803 ENSG00000155380 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A1 protein_coding protein_coding 126.1767 48.52653 200.1136 8.850441 4.602468 2.043749 7.184027 17.613624 0.00000 4.5154558 0.000000 -10.783295 0.1538500 0.3534000 0.0000000 -0.3534000 2.400364e-75 2.400364e-75 FALSE TRUE
MSTRG.1834.8 ENSG00000155380 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A1 protein_coding   126.1767 48.52653 200.1136 8.850441 4.602468 2.043749 39.700315 24.182294 63.49069 4.5098999 1.099686 1.392225 0.3695125 0.4975000 0.3178000 -0.1797000 2.855622e-12 2.400364e-75 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155380 E001 0.8502072 0.0153787590 5.942338e-02 1.256511e-01 1 112901677 112901733 57 - 0.113 0.497 2.849
ENSG00000155380 E002 1.3318089 0.0111871219 2.845531e-01 4.247982e-01 1 112911847 112911851 5 - 0.241 0.497 1.528
ENSG00000155380 E003 4.2199076 0.0048925562 1.407112e-01 2.489918e-01 1 112911852 112911855 4 - 0.565 0.870 1.263
ENSG00000155380 E004 86.9915615 0.0003966408 2.332221e-28 3.406571e-26 1 112911856 112912187 332 - 1.685 2.224 1.814
ENSG00000155380 E005 6440.6532242 0.0015857070 4.837996e-36 1.262457e-33 1 112912188 112914165 1978 - 3.661 3.877 0.716
ENSG00000155380 E006 19.9769229 0.0138068872 2.136860e-01 3.428745e-01 1 112916206 112917177 972 - 1.183 1.400 0.759
ENSG00000155380 E007 3699.5137332 0.0003780828 7.340383e-46 3.565676e-43 1 112917178 112918017 840 - 3.483 3.438 -0.148
ENSG00000155380 E008 534.8745017 0.0001255109 8.129618e-19 4.540483e-17 1 112918018 112918044 27 - 2.651 2.575 -0.252
ENSG00000155380 E009 887.9174175 0.0001407873 4.152756e-29 6.469795e-27 1 112921990 112922133 144 - 2.870 2.793 -0.256
ENSG00000155380 E010 4.4630116 0.0035692518 3.972757e-01 5.410339e-01 1 112922134 112922392 259 - 0.615 0.826 0.871
ENSG00000155380 E011 0.8115105 0.0159716693 5.216893e-03 1.652082e-02 1 112924769 112924808 40 - 0.060 0.585 4.261
ENSG00000155380 E012 2.1110567 0.0068282646 9.607919e-01 9.793136e-01 1 112929048 112929091 44 - 0.421 0.497 0.388
ENSG00000155380 E013 1016.6220118 0.0037039794 1.436871e-07 1.416216e-06 1 112929092 112929352 261 - 2.928 2.845 -0.278
ENSG00000155380 E014 0.0000000       1 112929881 112930034 154 -      
ENSG00000155380 E015 0.4502799 0.0306489561 6.184134e-01 7.360561e-01 1 112935824 112935996 173 - 0.160 0.001 -8.348
ENSG00000155380 E016 2.3283372 0.0061743060 4.577841e-01 5.980968e-01 1 112936077 112936119 43 - 0.467 0.385 -0.436
ENSG00000155380 E017 1.9134326 0.0082399001 1.993889e-01 3.254775e-01 1 112939119 112939270 152 - 0.444 0.234 -1.322
ENSG00000155380 E018 2.4443651 0.0081435571 3.903927e-01 5.343607e-01 1 112939351 112939421 71 - 0.488 0.385 -0.544
ENSG00000155380 E019 3.8406966 0.0041035544 1.256982e-02 3.489668e-02 1 112939422 112939491 70 - 0.673 0.234 -2.381
ENSG00000155380 E020 2.6688197 0.0056837204 6.971176e-02 1.428893e-01 1 112955276 112955378 103 - 0.547 0.234 -1.824
ENSG00000155380 E021 3.8639000 0.0266373986 7.136607e-01 8.100899e-01 1 112955379 112956034 656 - 0.583 0.722 0.596
ENSG00000155380 E022 454.0876195 0.0033661572 1.320147e-09 1.913234e-08 1 112956035 112956253 219 - 2.587 2.459 -0.426
ENSG00000155380 E023 0.0000000       1 112956839 112957013 175 -      
ENSG00000155380 E024 0.0000000       1 112957538 112957593 56 -