ENSG00000155329

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324170 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 6.231356 1.97749258 8.594127 0.29131077 1.1055417 2.114079 0.17708750 0.058766667 0.21113333 0.15236667 2.900733e-07 8.765485e-22 FALSE TRUE
ENST00000504170 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 16.027261 29.57018556 12.133078 3.19228000 0.1164040 -1.284497 0.55794583 0.872433333 0.30006667 -0.57236667 8.765485e-22 8.765485e-22   FALSE
ENST00000509008 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 2.642149 0.52322010 5.419520 0.26470476 0.6390633 3.348022 0.07430000 0.016866667 0.13463333 0.11776667 9.102144e-02 8.765485e-22 FALSE FALSE
ENST00000509437 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 2.829526 1.16651534 7.319236 0.21006311 0.7832276 2.639143 0.07943750 0.035733333 0.18003333 0.14430000 5.013631e-07 8.765485e-22 FALSE TRUE
ENST00000513541 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 1.823871 0.09677195 2.623213 0.09677195 0.8751838 4.624220 0.05164167 0.002466667 0.06316667 0.06070000 5.698501e-03 8.765485e-22 FALSE FALSE
ENST00000513848 ENSG00000155329 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC10 protein_coding protein_coding 31.73625 33.75928 40.58527 2.765082 1.619423 0.2656003 1.400731 0.42509171 2.932747 0.23524947 0.7579171 2.757772 0.03878750 0.013700000 0.07136667 0.05766667 2.049178e-01 8.765485e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155329 E001 1.4768929 0.0092663197 6.493758e-02 1.349313e-01 5 132996985 132996995 11 - 0.234 0.599 2.060
ENSG00000155329 E002 263.1629893 0.0026696554 1.152837e-06 9.448070e-06 5 132996996 132998211 1216 - 2.391 2.309 -0.273
ENSG00000155329 E003 94.1422616 0.0003235351 1.350107e-07 1.337588e-06 5 132998212 132998407 196 - 1.962 1.806 -0.525
ENSG00000155329 E004 40.3058476 0.0005552334 2.073391e-06 1.607323e-05 5 132998408 132998412 5 - 1.617 1.362 -0.878
ENSG00000155329 E005 82.9998786 0.0003624357 1.402787e-08 1.683051e-07 5 132998413 132998527 115 - 1.916 1.722 -0.655
ENSG00000155329 E006 115.0481908 0.0005714147 3.262574e-13 8.620431e-12 5 132998528 132998616 89 - 2.063 1.837 -0.760
ENSG00000155329 E007 123.1241236 0.0002798572 4.390959e-13 1.141559e-11 5 132998617 132998704 88 - 2.089 1.884 -0.689
ENSG00000155329 E008 119.0007055 0.0003103880 6.611891e-11 1.201537e-09 5 132998705 132998832 128 - 2.070 1.890 -0.604
ENSG00000155329 E009 54.2228477 0.0004827465 1.164057e-04 5.974078e-04 5 132998833 132998850 18 - 1.726 1.578 -0.502
ENSG00000155329 E010 56.1761861 0.0004648933 1.278950e-04 6.495795e-04 5 133000132 133000173 42 - 1.740 1.598 -0.483
ENSG00000155329 E011 11.4592162 0.0111476448 5.770218e-03 1.800936e-02 5 133000174 133000201 28 - 1.106 0.803 -1.136
ENSG00000155329 E012 112.5403957 0.0002641726 1.285921e-15 4.799328e-14 5 133006759 133006920 162 - 2.058 1.802 -0.860
ENSG00000155329 E013 0.2966881 0.0274424043 6.885239e-01   5 133011339 133011455 117 - 0.132 0.000 -8.629
ENSG00000155329 E014 98.0987840 0.0106817278 2.005310e-49 1.172531e-46 5 133019038 133019203 166 - 1.440 2.403 3.248
ENSG00000155329 E015 123.5819228 0.0047869119 3.143145e-35 7.804186e-33 5 133022841 133022906 66 - 1.785 2.391 2.030
ENSG00000155329 E016 1.6158246 0.0106828213 7.780869e-01 8.572262e-01 5 133026493 133026496 4 - 0.352 0.445 0.518
ENSG00000155329 E017 137.6889079 0.0022923510 2.810204e-23 2.564473e-21 5 133026497 133026604 108 - 1.931 2.356 1.419