ENSG00000155313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285679 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding protein_coding 11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 0.5093636 0.00000000 1.9686083 0.00000000 0.2300386 7.6283422 0.04255417 0.00000000 0.11770000 0.1177000000 5.881301e-07 4.185683e-09 FALSE TRUE
ENST00000449491 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding protein_coding 11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 0.7384641 0.06361129 0.4222583 0.06361129 0.4222583 2.5538948 0.06674583 0.02440000 0.02423333 -0.0001666667 8.443484e-01 4.185683e-09 FALSE FALSE
ENST00000453553 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding protein_coding 11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 2.9222422 0.28933359 4.8026806 0.28933359 0.5203669 4.0070146 0.20914167 0.07060000 0.28126667 0.2106666667 1.431814e-01 4.185683e-09 FALSE FALSE
ENST00000547201 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding processed_transcript 11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 1.4572937 0.00000000 2.8489090 0.00000000 0.6156490 8.1593209 0.07514167 0.00000000 0.16350000 0.1635000000 4.185683e-09 4.185683e-09 FALSE TRUE
MSTRG.21140.6 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding   11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 1.2983814 0.87805693 1.4543593 0.54678781 0.4131606 0.7215455 0.12780833 0.24956667 0.08473333 -0.1648333333 7.808709e-01 4.185683e-09 FALSE TRUE
MSTRG.21140.7 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding   11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 2.3281785 0.20389616 2.5453178 0.13493088 0.4261590 3.5785203 0.20820000 0.05686667 0.14663333 0.0897666667 3.006648e-01 4.185683e-09 FALSE TRUE
MSTRG.21140.9 ENSG00000155313 HEK293_OSMI2_2hA HEK293_TMG_2hB USP25 protein_coding   11.43992 3.101073 17.11945 0.4982926 1.082198 2.460995 1.0131538 1.46581220 0.4484416 0.49354908 0.1001256 -1.6866992 0.17852500 0.53830000 0.02703333 -0.5112666667 3.467922e-03 4.185683e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155313 E001 7.7731921 0.0024537326 2.114705e-02 5.390898e-02 21 15729982 15730024 43 + 0.942 0.617 -1.303
ENSG00000155313 E002 16.6264502 0.0029979790 3.035522e-07 2.806043e-06 21 15730025 15730330 306 + 1.276 0.617 -2.507
ENSG00000155313 E003 11.0112005 0.0274760555 1.996651e-03 7.215664e-03 21 15730331 15730438 108 + 1.095 0.618 -1.863
ENSG00000155313 E004 0.6611159 0.0226295954 8.962844e-01 9.377137e-01 21 15730514 15730580 67 + 0.178 0.212 0.316
ENSG00000155313 E005 0.9879930 0.0140684339 5.347361e-01 6.667423e-01 21 15730581 15730623 43 + 0.224 0.354 0.900
ENSG00000155313 E006 1.7370373 0.0081748349 7.448718e-01 8.330503e-01 21 15730624 15730688 65 + 0.401 0.354 -0.271
ENSG00000155313 E007 25.1436531 0.0018725420 6.694657e-08 7.033170e-07 21 15762891 15762968 78 + 1.436 0.898 -1.927
ENSG00000155313 E008 18.7671311 0.0009635100 1.532766e-06 1.222901e-05 21 15765997 15766001 5 + 1.316 0.780 -1.972
ENSG00000155313 E009 46.7391171 0.0005035303 7.772000e-09 9.776774e-08 21 15766002 15766141 140 + 1.681 1.298 -1.319
ENSG00000155313 E010 1.3662668 0.0096913715 3.940496e-01 5.379476e-01 21 15773256 15773317 62 + 0.371 0.212 -1.102
ENSG00000155313 E011 47.3463868 0.0004707849 4.276552e-07 3.834446e-06 21 15777904 15778027 124 + 1.680 1.362 -1.091
ENSG00000155313 E012 56.9194914 0.0058117410 1.549128e-05 9.855187e-05 21 15791502 15791664 163 + 1.753 1.467 -0.976
ENSG00000155313 E013 0.2966881 0.0290785164 9.030831e-01   21 15799534 15799756 223 + 0.126 0.000 -9.505
ENSG00000155313 E014 33.1451067 0.0172102895 6.380359e-02 1.330274e-01 21 15799757 15799843 87 + 1.499 1.342 -0.543
ENSG00000155313 E015 54.3583711 0.0023926033 5.499304e-04 2.346509e-03 21 15805121 15805258 138 + 1.715 1.520 -0.665
ENSG00000155313 E016 0.4513240 0.1923104431 6.562829e-01 7.659376e-01 21 15805259 15805655 397 + 0.126 0.210 0.879
ENSG00000155313 E017 47.4324109 0.0005417073 1.089279e-02 3.090805e-02 21 15808809 15808885 77 + 1.645 1.511 -0.457
ENSG00000155313 E018 45.7115550 0.0010267545 5.749873e-02 1.223351e-01 21 15811137 15811210 74 + 1.623 1.528 -0.325
ENSG00000155313 E019 50.6000767 0.0005953970 1.972920e-01 3.228531e-01 21 15818698 15818846 149 + 1.658 1.608 -0.168
ENSG00000155313 E020 50.6625850 0.0004926732 6.871766e-02 1.412398e-01 21 15824039 15824166 128 + 1.663 1.581 -0.279
ENSG00000155313 E021 41.2165350 0.0007855436 3.764177e-05 2.184110e-04 21 15824966 15825009 44 + 1.609 1.337 -0.933
ENSG00000155313 E022 35.7740351 0.0007727260 5.328434e-05 2.981616e-04 21 15825010 15825061 52 + 1.555 1.269 -0.988
ENSG00000155313 E023 63.2608019 0.0067066202 3.035197e-02 7.266086e-02 21 15826204 15826365 162 + 1.763 1.651 -0.381
ENSG00000155313 E024 89.9507760 0.0003960769 1.460527e-02 3.960500e-02 21 15826977 15827203 227 + 1.909 1.826 -0.278
ENSG00000155313 E025 51.2421401 0.0005429858 1.282051e-01 2.316508e-01 21 15830531 15830601 71 + 1.664 1.602 -0.213
ENSG00000155313 E026 95.9509829 0.0003445248 2.258714e-01 3.574317e-01 21 15831401 15831629 229 + 1.925 1.901 -0.081
ENSG00000155313 E027 79.2188002 0.0016853701 2.748440e-01 4.140659e-01 21 15833348 15833548 201 + 1.818 1.897 0.268
ENSG00000155313 E028 61.1077608 0.0015769865 8.780755e-02 1.717985e-01 21 15842398 15842517 120 + 1.698 1.813 0.391
ENSG00000155313 E029 35.7656250 0.0005995584 1.689123e-03 6.248199e-03 21 15842518 15842540 23 + 1.436 1.659 0.762
ENSG00000155313 E030 0.2944980 0.3698467413 1.000000e+00   21 15847663 15847776 114 + 0.126 0.000 -9.504
ENSG00000155313 E031 4.8964413 0.0038455418 6.360405e-01 7.501647e-01 21 15849777 15849872 96 + 0.731 0.678 -0.217
ENSG00000155313 E032 82.5069715 0.0003510903 2.289770e-03 8.118640e-03 21 15864268 15864446 179 + 1.811 1.967 0.526
ENSG00000155313 E033 66.0985937 0.0004242986 1.567509e-03 5.853963e-03 21 15866266 15866344 79 + 1.707 1.883 0.597
ENSG00000155313 E034 62.5059775 0.0009988804 2.517686e-03 8.816251e-03 21 15870068 15870147 80 + 1.684 1.862 0.598
ENSG00000155313 E035 55.0148652 0.0026526444 6.946102e-04 2.879345e-03 21 15874403 15874526 124 + 1.621 1.834 0.722
ENSG00000155313 E036 3.8539442 0.0192706883 8.135237e-01 8.817719e-01 21 15875996 15877795 1800 + 0.640 0.617 -0.099
ENSG00000155313 E037 87.8598435 0.0002992338 1.611662e-08 1.911744e-07 21 15877796 15877991 196 + 1.805 2.057 0.847
ENSG00000155313 E038 193.5732163 0.0086558384 5.550061e-12 1.204263e-10 21 15878303 15880184 1882 + 2.108 2.461 1.177
ENSG00000155313 E039 1.6232115 0.0174715277 2.147580e-01 3.441493e-01 21 15890634 15890684 51 + 0.304 0.546 1.314
ENSG00000155313 E040 2.2905553 0.0070907419 2.499012e-02 6.185398e-02 21 15894299 15894354 56 + 0.338 0.732 1.898