ENSG00000155287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370495 ENSG00000155287 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A28 protein_coding protein_coding 31.8407 48.21097 21.20132 1.244134 2.029005 -1.184826 25.611145 43.750466 15.052579 1.7983034 0.2396723 -1.5386593 0.78231250 0.9068333 0.72090000 -0.18593333 8.121155e-03 2.576347e-05 FALSE TRUE
ENST00000479722 ENSG00000155287 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A28 protein_coding retained_intron 31.8407 48.21097 21.20132 1.244134 2.029005 -1.184826 2.962765 2.006165 2.769166 0.1623915 0.4579316 0.4630385 0.10390000 0.0417000 0.13100000 0.08930000 2.576347e-05 2.576347e-05 FALSE TRUE
ENST00000496035 ENSG00000155287 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A28 protein_coding processed_transcript 31.8407 48.21097 21.20132 1.244134 2.029005 -1.184826 1.523428 0.360474 1.828937 0.3604740 1.8289367 2.3114277 0.05509167 0.0077000 0.07313333 0.06543333 9.445057e-01 2.576347e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155287 E001 498.282209 0.0005414671 1.301889e-06 1.055005e-05 10 99610522 99610932 411 - 2.550 2.644 0.313
ENSG00000155287 E002 228.511790 0.0002047788 2.929006e-02 7.056455e-02 10 99610933 99610985 53 - 2.240 2.299 0.197
ENSG00000155287 E003 700.374260 0.0002484046 3.219918e-01 4.652646e-01 10 99610986 99611366 381 - 2.759 2.774 0.048
ENSG00000155287 E004 224.885968 0.0002142222 8.335746e-01 8.957459e-01 10 99612543 99612599 57 - 2.282 2.276 -0.018
ENSG00000155287 E005 36.422567 0.0068912297 1.184527e-08 1.440618e-07 10 99612600 99612617 18 - 1.766 1.366 -1.366
ENSG00000155287 E006 69.383531 0.0004268422 7.438484e-29 1.131886e-26 10 99613469 99613695 227 - 2.085 1.612 -1.593
ENSG00000155287 E007 334.202328 0.0011908373 7.944777e-01 8.686976e-01 10 99613696 99613924 229 - 2.453 2.447 -0.020
ENSG00000155287 E008 160.377150 0.0004916605 6.722613e-01 7.782856e-01 10 99620045 99620439 395 - 2.143 2.129 -0.044
ENSG00000155287 E009 1.140439 0.2311327116 2.529664e-01 3.894117e-01 10 99620533 99620609 77 - 0.500 0.202 -1.870