ENSG00000155256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337540 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding protein_coding 28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 1.582291 1.563691 1.916998 0.3541955 0.4186738 0.2922022 0.0586125 0.0358000 0.11876667 0.08296667 0.008187998 4.450458e-09 FALSE TRUE
ENST00000359980 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding protein_coding 28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 3.860275 6.777488 2.915127 1.4715878 0.2887231 -1.2143784 0.1318708 0.1569667 0.18143333 0.02446667 0.797612404 4.450458e-09 FALSE TRUE
ENST00000477521 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding processed_transcript 28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 4.613675 9.297589 0.588115 1.8511854 0.4648228 -3.9599126 0.1294042 0.2155667 0.03360000 -0.18196667 0.092594100 4.450458e-09   FALSE
MSTRG.4459.10 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding   28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 4.085755 6.147828 3.307125 1.0435395 0.2834392 -0.8924880 0.1583917 0.1434333 0.20843333 0.06500000 0.380726790 4.450458e-09 FALSE TRUE
MSTRG.4459.14 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding   28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 3.648777 5.589199 1.446634 0.6697507 0.7308728 -1.9425817 0.1371833 0.1290000 0.08703333 -0.04196667 0.751968118 4.450458e-09 FALSE TRUE
MSTRG.4459.8 ENSG00000155256 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE27 protein_coding   28.52464 43.22734 16.06165 1.388858 0.949732 -1.42776 5.382055 7.133986 3.359150 0.6465326 0.7994579 -1.0843446 0.1978458 0.1645667 0.21363333 0.04906667 0.783469291 4.450458e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155256 E001 1.0747755 0.0169608463 1.610229e-02 0.0429634005 10 97737121 97737122 2 + 0.552 0.150 -2.640
ENSG00000155256 E002 1.5530662 0.0392794326 1.418248e-01 0.2505404017 10 97737123 97737127 5 + 0.553 0.306 -1.325
ENSG00000155256 E003 2.0775423 0.0187221518 4.800923e-02 0.1056503857 10 97737128 97737129 2 + 0.662 0.349 -1.542
ENSG00000155256 E004 2.3805731 0.1041054423 3.483467e-02 0.0813325680 10 97737130 97737131 2 + 0.751 0.348 -1.917
ENSG00000155256 E005 4.0382149 0.0044420888 1.390949e-04 0.0006995873 10 97737132 97737137 6 + 0.965 0.456 -2.146
ENSG00000155256 E006 9.4987898 0.0020200223 5.291876e-05 0.0002963961 10 97737138 97737139 2 + 1.215 0.818 -1.468
ENSG00000155256 E007 54.1931433 0.0040856370 1.071210e-01 0.2012888884 10 97737140 97737182 43 + 1.719 1.660 -0.199
ENSG00000155256 E008 142.4057239 0.0020479493 1.950022e-03 0.0070718539 10 97737183 97737321 139 + 2.147 2.068 -0.265
ENSG00000155256 E009 12.4498098 0.0013863084 2.339658e-01 0.3671007382 10 97737322 97737325 4 + 1.125 1.038 -0.316
ENSG00000155256 E010 194.4419237 0.0017826858 1.630359e-02 0.0433972103 10 97738477 97738649 173 + 2.255 2.213 -0.138
ENSG00000155256 E011 86.2768109 0.0046819298 3.358179e-01 0.4796382110 10 97738650 97738674 25 + 1.884 1.872 -0.038
ENSG00000155256 E012 1.9134260 0.1547831993 6.580977e-01 0.7672961425 10 97738675 97738845 171 + 0.307 0.433 0.737
ENSG00000155256 E013 121.0941704 0.0061166910 4.625905e-01 0.6024485281 10 97743094 97743164 71 + 2.016 2.021 0.016
ENSG00000155256 E014 221.7097738 0.0030211560 2.272173e-01 0.3590830440 10 97744729 97744915 187 + 2.283 2.280 -0.010
ENSG00000155256 E015 133.2919133 0.0076130098 6.228539e-01 0.7395755163 10 97748269 97748364 96 + 2.012 2.077 0.221
ENSG00000155256 E016 181.4505812 0.0047777127 9.191810e-01 0.9529432513 10 97749474 97749586 113 + 2.170 2.204 0.113
ENSG00000155256 E017 3.3590898 0.0047233029 1.807448e-04 0.0008811519 10 97750033 97750330 298 + 0.913 0.388 -2.316
ENSG00000155256 E018 218.5547297 0.0002037525 3.789321e-03 0.0125524667 10 97750331 97750470 140 + 2.304 2.265 -0.129
ENSG00000155256 E019 27.5242431 0.0089566958 1.071716e-01 0.2013620255 10 97751376 97751390 15 + 1.466 1.370 -0.332
ENSG00000155256 E020 167.5628885 0.0047451455 1.741474e-01 0.2935570657 10 97751391 97751462 72 + 2.179 2.159 -0.066
ENSG00000155256 E021 0.5944058 0.2975428553 7.951118e-01 0.8691199923 10 97752857 97752877 21 + 0.180 0.155 -0.266
ENSG00000155256 E022 218.8440330 0.0050127489 9.126861e-01 0.9486601498 10 97753038 97753182 145 + 2.250 2.286 0.120
ENSG00000155256 E023 13.9878446 0.0012843370 2.246242e-01 0.3559844693 10 97757203 97757264 62 + 0.988 1.152 0.596
ENSG00000155256 E024 131.9540446 0.0002762626 4.903531e-01 0.6276932934 10 97757265 97757311 47 + 2.045 2.059 0.046
ENSG00000155256 E025 162.3452246 0.0002237342 3.764670e-01 0.5207932391 10 97757642 97757723 82 + 2.140 2.151 0.035
ENSG00000155256 E026 7.3661606 0.0026665700 7.821803e-01 0.8601563474 10 97757868 97758171 304 + 0.823 0.892 0.267
ENSG00000155256 E027 1436.9361899 0.0041808418 1.289994e-04 0.0006545049 10 97759236 97760907 1672 + 2.998 3.123 0.415