ENSG00000155254

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285605 ENSG00000155254 HEK293_OSMI2_2hA HEK293_TMG_2hB MARVELD1 protein_coding protein_coding 46.36348 80.5693 27.29529 4.256958 0.7203257 -1.561229 23.229979 30.74557 18.026260 3.648806 0.3877942 -0.7699476 0.5522833 0.3801333 0.6606 0.28046667 2.928230e-07 2.92823e-07 TRUE TRUE
ENST00000434038 ENSG00000155254 HEK293_OSMI2_2hA HEK293_TMG_2hB MARVELD1 protein_coding processed_transcript 46.36348 80.5693 27.29529 4.256958 0.7203257 -1.561229 15.456309 33.23704 5.891844 1.831283 0.4452234 -2.4939882 0.2950792 0.4140000 0.2167 -0.19730000 8.693730e-05 2.92823e-07   FALSE
MSTRG.4454.1 ENSG00000155254 HEK293_OSMI2_2hA HEK293_TMG_2hB MARVELD1 protein_coding   46.36348 80.5693 27.29529 4.256958 0.7203257 -1.561229 7.101698 15.99903 3.247912 1.213971 0.6546600 -2.2968664 0.1410542 0.1983667 0.1180 -0.08036667 4.979522e-02 2.92823e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155254 E001 0.0000000       10 97713001 97713076 76 +      
ENSG00000155254 E002 0.0000000       10 97713077 97713172 96 +      
ENSG00000155254 E003 0.0000000       10 97713173 97713285 113 +      
ENSG00000155254 E004 0.3268771 0.0274424043 4.820803e-01   10 97713517 97713561 45 + 0.180 0.081 -1.321
ENSG00000155254 E005 338.1685769 0.0112800975 5.361779e-05 2.998326e-04 10 97713730 97714693 964 + 2.592 2.414 -0.594
ENSG00000155254 E006 361.0011814 0.0014312821 1.011928e-05 6.716657e-05 10 97714694 97715070 377 + 2.560 2.469 -0.305
ENSG00000155254 E007 467.3453110 0.0001357967 9.980661e-06 6.635106e-05 10 97715071 97715320 250 + 2.645 2.587 -0.194
ENSG00000155254 E008 287.5268031 0.0003432579 5.049497e-02 1.100452e-01 10 97715321 97715405 85 + 2.411 2.385 -0.088
ENSG00000155254 E009 624.2760126 0.0002548683 1.391469e-01 2.468902e-01 10 97715406 97715728 323 + 2.729 2.727 -0.009
ENSG00000155254 E010 439.8825178 0.0001265944 8.077444e-01 8.778380e-01 10 97715729 97715859 131 + 2.564 2.580 0.054
ENSG00000155254 E011 480.0166839 0.0001826743 1.507709e-01 2.627306e-01 10 97715860 97715985 126 + 2.577 2.625 0.159
ENSG00000155254 E012 1709.2238775 0.0027389658 6.040713e-09 7.770199e-08 10 97717194 97718150 957 + 3.062 3.200 0.457