ENSG00000155189

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285518 ENSG00000155189 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT5 protein_coding protein_coding 9.062154 3.024107 15.07413 0.1720026 0.3530628 2.313688 8.3504244 2.3032674 14.400466 0.26747591 0.2160103 2.63911300 0.8721500 0.75703333 0.95590000 0.19886667 0.01043793 0.01043793 FALSE TRUE
ENST00000523586 ENSG00000155189 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT5 protein_coding nonsense_mediated_decay 9.062154 3.024107 15.07413 0.1720026 0.3530628 2.313688 0.3275509 0.4282681 0.225244 0.09278719 0.1630664 -0.89765564 0.0705625 0.14393333 0.01446667 -0.12946667 0.02425559 0.01043793   FALSE
MSTRG.31067.2 ENSG00000155189 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT5 protein_coding   9.062154 3.024107 15.07413 0.1720026 0.3530628 2.313688 0.2047336 0.2925714 0.303599 0.16835557 0.2499380 0.05164536 0.0272000 0.09903333 0.02006667 -0.07896667 0.54968659 0.01043793 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155189 E001 10.687364 0.0121517215 3.874033e-01 5.315323e-01 8 6708642 6708645 4 + 0.955 1.068 0.418
ENSG00000155189 E002 18.774798 0.0152835451 9.871638e-01 9.960333e-01 8 6708646 6708665 20 + 1.204 1.205 0.003
ENSG00000155189 E003 28.136796 0.0099018079 9.039203e-01 9.428700e-01 8 6708666 6708692 27 + 1.372 1.365 -0.027
ENSG00000155189 E004 57.529074 0.0035433842 1.284167e-01 2.319502e-01 8 6708693 6708859 167 + 1.691 1.597 -0.321
ENSG00000155189 E005 34.310296 0.0081523558 6.986267e-01 7.985440e-01 8 6708860 6708887 28 + 1.463 1.436 -0.091
ENSG00000155189 E006 6.402405 0.0052508761 4.824589e-13 1.245407e-11 8 6708888 6709162 275 + 0.395 1.307 3.698
ENSG00000155189 E007 4.223022 0.1097600104 2.212719e-05 1.357930e-04 8 6709481 6709542 62 + 0.310 1.124 3.560
ENSG00000155189 E008 35.615153 0.0006081236 3.223483e-01 4.656622e-01 8 6724870 6724939 70 + 1.481 1.414 -0.229
ENSG00000155189 E009 75.650600 0.0006611798 8.484685e-02 1.671614e-01 8 6730711 6730826 116 + 1.803 1.719 -0.283
ENSG00000155189 E010 90.144980 0.0003331803 4.799428e-01 6.182848e-01 8 6732561 6732650 90 + 1.870 1.846 -0.082
ENSG00000155189 E011 0.000000       8 6738376 6738550 175 +      
ENSG00000155189 E012 72.840130 0.0003893468 3.284441e-01 4.719458e-01 8 6741661 6741751 91 + 1.761 1.819 0.194
ENSG00000155189 E013 0.000000       8 6745755 6746241 487 +      
ENSG00000155189 E014 48.843170 0.0004547224 2.301391e-01 3.626291e-01 8 6747670 6747683 14 + 1.588 1.669 0.275
ENSG00000155189 E015 110.762439 0.0006036048 8.076150e-01 8.777681e-01 8 6747684 6747828 145 + 1.953 1.951 -0.006
ENSG00000155189 E016 108.332924 0.0003367694 1.316735e-01 2.364739e-01 8 6755051 6755174 124 + 1.956 1.900 -0.189
ENSG00000155189 E017 858.935831 0.0049380340 9.591046e-01 9.783675e-01 8 6757163 6761503 4341 + 2.838 2.844 0.019