ENSG00000155111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323817 ENSG00000155111 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK19 protein_coding protein_coding 5.278974 2.893721 6.767594 0.1474453 0.3116201 1.222871 1.6555204 1.21320381 1.9771909 0.20669624 0.23026685 0.7000657 0.31473750 0.41600000 0.29203333 -0.12396667 3.420763e-01 6.821197e-05 FALSE TRUE
ENST00000368911 ENSG00000155111 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK19 protein_coding protein_coding 5.278974 2.893721 6.767594 0.1474453 0.3116201 1.222871 1.7163164 0.05548114 2.6452411 0.05548114 0.20205767 5.3416197 0.29017500 0.01903333 0.39283333 0.37380000 6.821197e-05 6.821197e-05 FALSE TRUE
ENST00000413605 ENSG00000155111 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK19 protein_coding protein_coding 5.278974 2.893721 6.767594 0.1474453 0.3116201 1.222871 0.1751776 0.47424246 0.1196339 0.25079852 0.06075188 -1.9012871 0.04353333 0.16876667 0.01746667 -0.15130000 5.288130e-01 6.821197e-05 FALSE TRUE
ENST00000468997 ENSG00000155111 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK19 protein_coding processed_transcript 5.278974 2.893721 6.767594 0.1474453 0.3116201 1.222871 0.4281076 0.65531272 0.2803560 0.17311996 0.19416280 -1.1962098 0.09883333 0.23340000 0.03920000 -0.19420000 1.190705e-01 6.821197e-05   FALSE
ENST00000497709 ENSG00000155111 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK19 protein_coding processed_transcript 5.278974 2.893721 6.767594 0.1474453 0.3116201 1.222871 0.5941914 0.41283167 0.5243773 0.26438677 0.32798071 0.3377753 0.14625417 0.13430000 0.08113333 -0.05316667 9.184206e-01 6.821197e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155111 E001 386.3017281 0.0009763045 1.912582e-19 1.148805e-17 6 110609978 110614282 4305 - 2.503 2.646 0.477
ENSG00000155111 E002 25.4089412 0.0008669286 1.100379e-06 9.054180e-06 6 110614283 110614475 193 - 1.471 1.055 -1.464
ENSG00000155111 E003 29.5104420 0.0007195429 3.446745e-04 1.558749e-03 6 110614476 110614666 191 - 1.512 1.253 -0.899
ENSG00000155111 E004 27.8675022 0.0007669328 1.793808e-02 4.700297e-02 6 110621104 110621370 267 - 1.468 1.303 -0.573
ENSG00000155111 E005 14.9629847 0.0012503567 3.594508e-02 8.347788e-02 6 110622088 110622166 79 - 1.214 1.011 -0.728
ENSG00000155111 E006 18.1240413 0.0018913635 3.534266e-03 1.182460e-02 6 110622815 110622912 98 - 1.306 1.034 -0.971
ENSG00000155111 E007 19.6337570 0.0060330151 2.781455e-03 9.618998e-03 6 110623290 110623362 73 - 1.342 1.056 -1.018
ENSG00000155111 E008 22.4574386 0.0152521871 5.945263e-03 1.846453e-02 6 110626776 110626845 70 - 1.397 1.116 -0.989
ENSG00000155111 E009 27.6666172 0.0094462897 5.882801e-04 2.490685e-03 6 110627002 110627145 144 - 1.491 1.182 -1.077
ENSG00000155111 E010 20.7150641 0.0009470298 6.893625e-04 2.860220e-03 6 110632030 110632161 132 - 1.372 1.075 -1.049
ENSG00000155111 E011 14.9425777 0.0125911245 6.653467e-05 3.633657e-04 6 110638649 110638706 58 - 1.267 0.771 -1.833
ENSG00000155111 E012 22.5409344 0.0546680471 1.242469e-02 3.455668e-02 6 110667434 110667574 141 - 1.415 1.074 -1.203
ENSG00000155111 E013 18.5106028 0.0049647357 3.903648e-02 8.926293e-02 6 110670431 110670541 111 - 1.302 1.114 -0.666
ENSG00000155111 E014 17.2180984 0.0010820730 2.740581e-03 9.494108e-03 6 110746126 110746201 76 - 1.294 1.011 -1.010
ENSG00000155111 E015 5.0125961 0.0040028295 2.484204e-01 3.840583e-01 6 110773876 110773937 62 - 0.796 0.630 -0.683
ENSG00000155111 E016 0.4375944 0.0262123244 3.856284e-01 5.298070e-01 6 110779470 110779547 78 - 0.199 0.001 -8.970
ENSG00000155111 E017 30.9944929 0.0008019408 2.520563e-21 1.875542e-19 6 110813159 110814124 966 - 1.193 1.792 2.065
ENSG00000155111 E018 22.3390472 0.0009193263 9.421246e-01 9.676742e-01 6 110815009 110815469 461 - 1.331 1.337 0.021
ENSG00000155111 E019 0.8136755 0.0145522959 5.287596e-01 6.616465e-01 6 110815571 110815637 67 - 0.200 0.320 0.902
ENSG00000155111 E020 3.3517295 0.0698170387 6.700129e-01 7.766122e-01 6 110815808 110815958 151 - 0.592 0.678 0.371