ENSG00000155085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285397 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding protein_coding 1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.92574702 0.53187248 1.38729388 0.090249496 0.15104556 1.366610 0.53756667 0.60953333 0.5374333 -0.072100000 0.7358134990 0.0002584707 FALSE TRUE
ENST00000355283 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding protein_coding 1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.07646522 0.02804143 0.09267951 0.006257316 0.04638802 1.432505 0.05275000 0.03216667 0.0368000 0.004633333 0.9128879816 0.0002584707 FALSE TRUE
ENST00000466992 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding retained_intron 1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.04601585 0.15007123 0.00000000 0.050637888 0.00000000 -4.000642 0.04625417 0.17736667 0.0000000 -0.177366667 0.0002584707 0.0002584707 FALSE TRUE
ENST00000490722 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding protein_coding 1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.01781608 0.05226417 0.00000000 0.026264682 0.00000000 -2.638402 0.02272917 0.05926667 0.0000000 -0.059266667 0.0539324072 0.0002584707 FALSE TRUE
ENST00000532976 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding protein_coding 1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.34022901 0.04646278 0.54781698 0.046462776 0.15482969 3.304420 0.17740417 0.05900000 0.2095333 0.150533333 0.2921351984 0.0002584707 FALSE TRUE
MSTRG.28783.6 ENSG00000155085 HEK293_OSMI2_2hA HEK293_TMG_2hB AK9 protein_coding   1.758692 0.8648725 2.604365 0.1051235 0.1677043 1.579316 0.10114132 0.04654661 0.15792252 0.026106024 0.05773134 1.570283 0.05957083 0.05046667 0.0630000 0.012533333 1.0000000000 0.0002584707 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155085 E001 0.0000000       6 109492855 109492858 4 -      
ENSG00000155085 E002 0.2903454 0.262917195 1.000000e+00   6 109492859 109493273 415 - 0.129 0.000 -10.497
ENSG00000155085 E003 1.0287911 0.013178524 1.285655e-01 2.321624e-01 6 109493274 109493571 298 - 0.182 0.452 1.813
ENSG00000155085 E004 0.2987644 0.028216387 1.000000e+00   6 109493981 109494095 115 - 0.130 0.000 -12.639
ENSG00000155085 E005 0.1515154 0.045123379 1.000000e+00   6 109495338 109495440 103 - 0.070 0.000 -11.835
ENSG00000155085 E006 0.5244761 0.316365858 6.470223e-01 7.587821e-01 6 109497465 109497563 99 - 0.130 0.210 0.835
ENSG00000155085 E007 0.8211642 0.191794211 1.000000e+00 1.000000e+00 6 109497796 109497965 170 - 0.230 0.209 -0.174
ENSG00000155085 E008 0.5985731 0.035944222 8.753804e-01 9.239720e-01 6 109499044 109499198 155 - 0.182 0.206 0.222
ENSG00000155085 E009 0.2955422 0.029502324 3.474252e-01   6 109499199 109499240 42 - 0.070 0.206 1.808
ENSG00000155085 E010 1.1982920 0.202452958 5.894613e-01 7.125280e-01 6 109506327 109506547 221 - 0.347 0.205 -1.019
ENSG00000155085 E011 1.0542652 0.604810870 4.011068e-01 5.447866e-01 6 109506654 109506800 147 - 0.348 0.000 -13.670
ENSG00000155085 E012 0.6060617 1.026327844 9.781113e-01 9.904482e-01 6 109509179 109509380 202 - 0.232 0.000 -12.984
ENSG00000155085 E013 0.7533107 0.401531967 4.054711e-01 5.491630e-01 6 109514224 109514437 214 - 0.273 0.000 -13.408
ENSG00000155085 E014 0.2998086 0.029695114 3.484983e-01   6 109515857 109516075 219 - 0.070 0.206 1.808
ENSG00000155085 E015 0.5922303 0.018217461 8.700006e-01 9.203655e-01 6 109516430 109516642 213 - 0.182 0.207 0.224
ENSG00000155085 E016 0.0000000       6 109527628 109527628 1 -      
ENSG00000155085 E017 0.7310603 0.046509635 9.828231e-01 9.933179e-01 6 109527629 109528751 1123 - 0.229 0.206 -0.192
ENSG00000155085 E018 0.4375944 0.023473678 5.421124e-01 6.729366e-01 6 109528752 109529010 259 - 0.182 0.000 -13.067
ENSG00000155085 E019 0.4439371 0.021783556 5.388450e-01 6.702157e-01 6 109529011 109529073 63 - 0.182 0.000 -13.068
ENSG00000155085 E020 0.7363589 0.015468986 2.534073e-01 3.899255e-01 6 109533251 109533470 220 - 0.272 0.000 -13.566
ENSG00000155085 E021 0.8856842 0.061064300 1.960232e-01 3.212485e-01 6 109542047 109542171 125 - 0.310 0.000 -13.715
ENSG00000155085 E022 1.1823723 0.010933427 9.693096e-02 1.858030e-01 6 109545867 109546127 261 - 0.378 0.000 -13.987
ENSG00000155085 E023 0.0000000       6 109549684 109550089 406 -      
ENSG00000155085 E024 0.4418608 0.025327384 5.410517e-01 6.721000e-01 6 109550090 109550302 213 - 0.182 0.000 -13.066
ENSG00000155085 E025 0.0000000       6 109550303 109550537 235 -      
ENSG00000155085 E026 0.4439371 0.021783556 5.388450e-01 6.702157e-01 6 109563597 109563712 116 - 0.182 0.000 -13.068
ENSG00000155085 E027 0.7320925 0.030828265 2.595178e-01 3.969198e-01 6 109564080 109564280 201 - 0.271 0.000 -13.559
ENSG00000155085 E028 0.7665478 0.016593769 9.653149e-01 9.821800e-01 6 109564756 109564845 90 - 0.229 0.207 -0.188
ENSG00000155085 E029 0.6192988 0.019469520 8.646362e-01 9.167533e-01 6 109573442 109573594 153 - 0.182 0.207 0.227
ENSG00000155085 E030 0.0000000       6 109579345 109579549 205 -      
ENSG00000155085 E031 0.2987644 0.028216387 1.000000e+00   6 109579550 109579626 77 - 0.130 0.000 -12.639
ENSG00000155085 E032 0.1515154 0.045123379 1.000000e+00   6 109585123 109585237 115 - 0.070 0.000 -11.835
ENSG00000155085 E033 0.9652040 0.416993501 6.206926e-01 7.377815e-01 6 109585916 109586072 157 - 0.230 0.348 0.813
ENSG00000155085 E034 2.0412115 0.148636847 4.501574e-01 5.913050e-01 6 109610365 109610513 149 - 0.379 0.545 0.849
ENSG00000155085 E035 1.4394162 0.082218079 1.068576e-01 2.009076e-01 6 109612010 109612093 84 - 0.229 0.542 1.836
ENSG00000155085 E036 1.5177822 0.009543315 3.354197e-01 4.792090e-01 6 109614183 109614296 114 - 0.409 0.207 -1.359
ENSG00000155085 E037 1.0414660 0.014492909 1.317214e-01 2.365172e-01 6 109614385 109614480 96 - 0.346 0.000 -13.870
ENSG00000155085 E038 0.7384352 0.016996152 2.535276e-01 3.900509e-01 6 109619092 109619158 67 - 0.272 0.000 -13.565
ENSG00000155085 E039 1.2125613 0.012226039 5.131947e-01 6.480250e-01 6 109619159 109619236 78 - 0.346 0.207 -0.996
ENSG00000155085 E040 33.6223047 0.012149839 4.438329e-07 3.966171e-06 6 109631693 109632922 1230 - 1.366 1.703 1.155
ENSG00000155085 E041 8.3693780 0.002162178 6.108458e-02 1.284611e-01 6 109632923 109633103 181 - 0.850 1.056 0.770
ENSG00000155085 E042 5.4103094 0.012982570 2.905074e-01 4.313282e-01 6 109633184 109633243 60 - 0.793 0.608 -0.770
ENSG00000155085 E043 6.7377526 0.016991903 3.797913e-01 5.240411e-01 6 109633244 109633323 80 - 0.871 0.722 -0.589
ENSG00000155085 E044 4.5245234 0.004037504 7.398411e-01 8.294465e-01 6 109641518 109641537 20 - 0.683 0.722 0.159
ENSG00000155085 E045 7.3538292 0.031044070 7.097260e-01 8.070306e-01 6 109641538 109641616 79 - 0.890 0.812 -0.302
ENSG00000155085 E046 0.1515154 0.045123379 1.000000e+00   6 109644505 109644613 109 - 0.070 0.000 -11.835
ENSG00000155085 E047 6.8118627 0.102924466 4.735916e-01 6.125303e-01 6 109644614 109644669 56 - 0.880 0.720 -0.635
ENSG00000155085 E048 4.6857070 0.003369383 7.733698e-02 1.552172e-01 6 109644670 109644688 19 - 0.768 0.452 -1.411
ENSG00000155085 E049 10.1283943 0.001868627 3.092717e-01 4.515410e-01 6 109656756 109656884 129 - 1.023 0.887 -0.511
ENSG00000155085 E050 13.6045812 0.001887154 5.995840e-01 7.209461e-01 6 109659228 109659413 186 - 1.102 1.140 0.137
ENSG00000155085 E051 8.7614898 0.002114067 1.230863e-01 2.243549e-01 6 109662551 109662663 113 - 0.986 0.769 -0.833
ENSG00000155085 E052 7.9620678 0.002264982 4.361952e-01 5.782978e-01 6 109671919 109672015 97 - 0.928 0.812 -0.445
ENSG00000155085 E053 6.6157101 0.014293869 4.165255e-01 5.598802e-01 6 109672115 109672167 53 - 0.860 0.722 -0.548
ENSG00000155085 E054 8.2150503 0.002882639 2.279810e-01 3.600243e-01 6 109674198 109674261 64 - 0.945 0.769 -0.680
ENSG00000155085 E055 8.6653302 0.002155607 1.584373e-01 2.730393e-01 6 109675629 109675756 128 - 0.970 0.769 -0.773
ENSG00000155085 E056 3.5169480 0.004662808 2.690010e-01 4.074632e-01 6 109690472 109690670 199 - 0.557 0.722 0.712
ENSG00000155085 E057 3.0070599 0.077372946 7.103053e-02 1.450541e-01 6 109691147 109691217 71 - 0.633 0.208 -2.425