ENSG00000155016

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332884 ENSG00000155016 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2U1 protein_coding protein_coding 2.76521 2.268758 3.344906 0.295098 0.03401153 0.5580244 2.2366708 1.4419738 2.8815302 0.0638749 0.01870919 0.99381778 0.79900000 0.6517667 0.86156667 0.20980000 0.01042858 0.01042858 FALSE TRUE
MSTRG.25285.4 ENSG00000155016 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2U1 protein_coding   2.76521 2.268758 3.344906 0.295098 0.03401153 0.5580244 0.1434411 0.1796364 0.1782920 0.1164880 0.04961274 -0.01026424 0.05135833 0.0737000 0.05313333 -0.02056667 0.96517753 0.01042858 FALSE TRUE
MSTRG.25285.5 ENSG00000155016 HEK293_OSMI2_2hA HEK293_TMG_2hB CYP2U1 protein_coding   2.76521 2.268758 3.344906 0.295098 0.03401153 0.5580244 0.2983386 0.5105056 0.2337893 0.2554943 0.05978910 -1.09427916 0.11285000 0.2054333 0.07003333 -0.13540000 0.69716592 0.01042858 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000155016 E001 2.9603189 0.0388131315 0.483195039 0.62124093 4 107931549 107931584 36 + 0.634 0.521 -0.511
ENSG00000155016 E002 2.9603189 0.0388131315 0.483195039 0.62124093 4 107931585 107931595 11 + 0.634 0.521 -0.511
ENSG00000155016 E003 8.6735733 0.0837460796 0.471236959 0.61038059 4 107931596 107931788 193 + 0.912 1.038 0.466
ENSG00000155016 E004 10.0264706 0.0682607360 0.197451075 0.32303568 4 107931789 107931894 106 + 0.939 1.129 0.698
ENSG00000155016 E005 27.3276868 0.0030691807 0.014423077 0.03918443 4 107931895 107932133 239 + 1.357 1.542 0.636
ENSG00000155016 E006 2.3950408 0.2602338421 0.348991138 0.49321123 4 107935595 107936516 922 + 0.376 0.631 1.247
ENSG00000155016 E007 0.3697384 0.0274424043 0.133559213 0.23908525 4 107936517 107936575 59 + 0.000 0.248 10.240
ENSG00000155016 E008 0.0000000       4 107936576 107936607 32 +      
ENSG00000155016 E009 0.1472490 0.0432242712 0.651939580   4 107938038 107938176 139 + 0.106 0.000 -9.341
ENSG00000155016 E010 28.8666100 0.0177209488 0.531864337 0.66426327 4 107944970 107945215 246 + 1.492 1.451 -0.140
ENSG00000155016 E011 38.0917551 0.0006446044 0.003660385 0.01218371 4 107945216 107945605 390 + 1.654 1.517 -0.467
ENSG00000155016 E012 32.0085018 0.0007144416 0.101005473 0.19199695 4 107947376 107947537 162 + 1.559 1.485 -0.254
ENSG00000155016 E013 29.9852615 0.0074373610 0.141902385 0.25064081 4 107949350 107949517 168 + 1.536 1.459 -0.264
ENSG00000155016 E014 230.5523853 0.0068735741 0.326176288 0.46961751 4 107950245 107953461 3217 + 2.347 2.390 0.142