ENSG00000154978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285279 ENSG00000154978 HEK293_OSMI2_2hA HEK293_TMG_2hB VOPP1 protein_coding protein_coding 30.22076 45.80854 21.12107 1.960044 0.5561383 -1.116566 27.884080 34.88729 20.66587 4.684099 0.5901883 -0.7551672 0.93543333 0.7577333 0.9783333 0.2206 5.591203e-05 4.669534e-10 FALSE TRUE
ENST00000428648 ENSG00000154978 HEK293_OSMI2_2hA HEK293_TMG_2hB VOPP1 protein_coding protein_coding 30.22076 45.80854 21.12107 1.960044 0.5561383 -1.116566 2.023584 10.38292 0.00000 3.438029 0.0000000 -10.0213858 0.05381667 0.2307000 0.0000000 -0.2307 4.669534e-10 4.669534e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154978 E001 1.2125613 0.0128083021 6.514127e-04 2.720759e-03 7 55436056 55436174 119 - 0.651 0.084 -4.027
ENSG00000154978 E002 1.0445985 0.3499151228 2.245834e-01 3.559377e-01 7 55470613 55470613 1 - 0.476 0.207 -1.707
ENSG00000154978 E003 991.9589409 0.0015194022 2.538406e-07 2.385029e-06 7 55470614 55471936 1323 - 2.865 2.966 0.337
ENSG00000154978 E004 169.8274483 0.0002887684 8.278708e-01 8.918070e-01 7 55471937 55471967 31 - 2.157 2.186 0.096
ENSG00000154978 E005 277.3717651 0.0001946658 9.802271e-01 9.916433e-01 7 55471968 55472202 235 - 2.372 2.395 0.076
ENSG00000154978 E006 144.3908945 0.0008901495 7.828918e-03 2.335141e-02 7 55472203 55472708 506 - 2.018 2.135 0.392
ENSG00000154978 E007 16.4663253 0.0010983822 4.302140e-01 5.728496e-01 7 55472709 55472753 45 - 1.228 1.178 -0.176
ENSG00000154978 E008 15.4805249 0.0012006427 2.588035e-01 3.961250e-01 7 55472754 55472776 23 - 1.228 1.146 -0.290
ENSG00000154978 E009 50.0521104 0.0009254171 3.169894e-02 7.526343e-02 7 55472777 55472884 108 - 1.726 1.633 -0.314
ENSG00000154978 E010 52.3037011 0.0020243802 6.331706e-02 1.322283e-01 7 55472885 55472916 32 - 1.734 1.654 -0.270
ENSG00000154978 E011 110.9725161 0.0002715419 5.819190e-03 1.813586e-02 7 55472917 55473014 98 - 2.050 1.974 -0.256
ENSG00000154978 E012 113.8094021 0.0018013933 1.354366e-01 2.417220e-01 7 55473015 55473045 31 - 2.031 1.991 -0.131
ENSG00000154978 E013 3.2076086 0.1542374435 8.853033e-01 9.306502e-01 7 55492263 55492281 19 - 0.543 0.584 0.187
ENSG00000154978 E014 110.2147446 0.0014142098 2.119333e-02 5.400370e-02 7 55492282 55492343 62 - 2.039 1.969 -0.234
ENSG00000154978 E015 62.1861561 0.0024396713 4.592103e-01 5.994474e-01 7 55492344 55492385 42 - 1.757 1.739 -0.061
ENSG00000154978 E016 64.9187088 0.0016588293 4.095234e-01 5.531364e-01 7 55492386 55492418 33 - 1.713 1.778 0.218
ENSG00000154978 E017 1.1341212 0.0139273287 9.850131e-01 9.946539e-01 7 55492840 55492973 134 - 0.300 0.315 0.100
ENSG00000154978 E018 0.3268771 0.0294621976 5.132518e-01   7 55493088 55493209 122 - 0.175 0.084 -1.219
ENSG00000154978 E019 94.6322000 0.0003396652 7.983898e-02 1.593155e-01 7 55497613 55497690 78 - 1.959 1.912 -0.158
ENSG00000154978 E020 0.0000000       7 55515936 55516077 142 -      
ENSG00000154978 E021 56.0910080 0.0004260878 4.819433e-07 4.275672e-06 7 55521072 55521130 59 - 1.855 1.633 -0.748
ENSG00000154978 E022 0.1482932 0.0414923561 1.000000e+00   7 55521581 55521870 290 - 0.000 0.084 8.482
ENSG00000154978 E023 0.0000000       7 55526735 55527022 288 -      
ENSG00000154978 E024 0.0000000       7 55530829 55530911 83 -      
ENSG00000154978 E025 0.0000000       7 55537501 55537558 58 -      
ENSG00000154978 E026 0.0000000       7 55537559 55537694 136 -      
ENSG00000154978 E027 0.0000000       7 55538613 55538660 48 -      
ENSG00000154978 E028 0.0000000       7 55539489 55539627 139 -      
ENSG00000154978 E029 0.0000000       7 55552653 55552852 200 -      
ENSG00000154978 E030 0.0000000       7 55553811 55553887 77 -      
ENSG00000154978 E031 2.2798575 0.0080102700 5.891996e-01 7.122680e-01 7 55561854 55561979 126 - 0.542 0.465 -0.373
ENSG00000154978 E032 1.8444558 0.0079554568 1.298482e-01 2.339475e-01 7 55561980 55562051 72 - 0.600 0.357 -1.223
ENSG00000154978 E033 0.1482932 0.0414923561 1.000000e+00   7 55571709 55571868 160 - 0.000 0.084 8.482
ENSG00000154978 E034 44.7251264 0.0005170757 2.345967e-13 6.331906e-12 7 55572271 55572502 232 - 1.839 1.474 -1.241
ENSG00000154978 E035 0.0000000       7 55572800 55572988 189 -