ENSG00000154920

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338165 ENSG00000154920 HEK293_OSMI2_2hA HEK293_TMG_2hB EME1 protein_coding protein_coding 16.80255 13.43908 16.50679 0.7539105 0.6235172 0.2964262 8.793818 7.0178807 9.121601 0.5559730 0.24449336 0.3777781 0.53256667 0.52086667 0.55310000 0.03223333 0.64612291 0.01991783 FALSE  
ENST00000507616 ENSG00000154920 HEK293_OSMI2_2hA HEK293_TMG_2hB EME1 protein_coding retained_intron 16.80255 13.43908 16.50679 0.7539105 0.6235172 0.2964262 1.697552 0.9367490 1.463496 0.1056961 0.22135443 0.6381889 0.09732083 0.07016667 0.08856667 0.01840000 0.66091247 0.01991783    
ENST00000510007 ENSG00000154920 HEK293_OSMI2_2hA HEK293_TMG_2hB EME1 protein_coding retained_intron 16.80255 13.43908 16.50679 0.7539105 0.6235172 0.2964262 1.443486 0.6580561 1.525432 0.2936688 0.04848595 1.2006035 0.08259167 0.05010000 0.09290000 0.04280000 0.37801938 0.01991783 TRUE  
ENST00000510246 ENSG00000154920 HEK293_OSMI2_2hA HEK293_TMG_2hB EME1 protein_coding protein_coding 16.80255 13.43908 16.50679 0.7539105 0.6235172 0.2964262 1.540975 2.7203938 1.787731 0.2424500 0.25757848 -0.6029316 0.09807500 0.20266667 0.10843333 -0.09423333 0.01991783 0.01991783 FALSE  
ENST00000514211 ENSG00000154920 HEK293_OSMI2_2hA HEK293_TMG_2hB EME1 protein_coding retained_intron 16.80255 13.43908 16.50679 0.7539105 0.6235172 0.2964262 2.317904 1.2785294 2.109600 0.1351253 0.47506445 0.7180664 0.13293750 0.09496667 0.12733333 0.03236667 0.67540306 0.01991783 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154920 E001 1.123049 0.1562015140 3.896721e-01 0.5337368757 17 50373220 50373228 9 + 0.416 0.221 -1.271
ENSG00000154920 E002 2.851554 0.0093626836 2.339312e-02 0.0585630065 17 50373229 50373241 13 + 0.738 0.367 -1.754
ENSG00000154920 E003 5.687123 0.0030017672 1.274888e-01 0.2306574783 17 50373242 50373253 12 + 0.922 0.725 -0.771
ENSG00000154920 E004 28.720310 0.0214018105 2.903801e-01 0.4311729708 17 50373254 50373277 24 + 1.522 1.412 -0.378
ENSG00000154920 E005 124.919015 0.0003577711 9.883992e-05 0.0005164215 17 50375185 50375512 328 + 2.162 2.037 -0.416
ENSG00000154920 E006 98.428803 0.0002988848 1.119018e-01 0.2083690490 17 50375513 50375687 175 + 2.030 1.972 -0.194
ENSG00000154920 E007 72.439921 0.0003376155 5.548594e-01 0.6837821137 17 50375688 50375796 109 + 1.883 1.857 -0.089
ENSG00000154920 E008 109.212572 0.0012340232 9.797518e-01 0.9914007211 17 50375797 50375983 187 + 2.048 2.043 -0.016
ENSG00000154920 E009 57.657249 0.0035373225 8.406950e-02 0.1659188225 17 50376066 50376108 43 + 1.819 1.723 -0.324
ENSG00000154920 E010 75.421232 0.0004161714 8.132632e-01 0.8815894757 17 50376109 50376193 85 + 1.894 1.882 -0.041
ENSG00000154920 E011 32.576978 0.0008727279 2.218642e-01 0.3526280998 17 50378595 50378599 5 + 1.573 1.498 -0.259
ENSG00000154920 E012 56.909302 0.0004718831 5.759343e-01 0.7014537607 17 50378600 50378681 82 + 1.784 1.756 -0.095
ENSG00000154920 E013 93.514402 0.0011551768 1.346017e-01 0.2405558451 17 50378774 50378882 109 + 1.952 2.007 0.186
ENSG00000154920 E014 56.165061 0.0005118839 1.058454e-02 0.0301739510 17 50378883 50378895 13 + 1.698 1.814 0.393
ENSG00000154920 E015 17.430909 0.0019466902 2.732947e-02 0.0666652006 17 50378896 50379067 172 + 1.357 1.173 -0.644
ENSG00000154920 E016 12.880419 0.0013430157 7.989652e-01 0.8717276490 17 50379068 50379106 39 + 1.159 1.133 -0.092
ENSG00000154920 E017 93.157581 0.0004105432 1.128963e-02 0.0318508659 17 50379107 50379224 118 + 1.930 2.018 0.297
ENSG00000154920 E018 89.866751 0.0012434466 2.398552e-02 0.0597782591 17 50379452 50379567 116 + 1.915 1.999 0.284
ENSG00000154920 E019 19.828221 0.0526211622 2.473240e-01 0.3827943688 17 50379568 50379758 191 + 1.391 1.235 -0.546
ENSG00000154920 E020 39.089025 0.0455224551 4.799154e-02 0.1056209826 17 50379759 50380311 553 + 1.706 1.479 -0.774
ENSG00000154920 E021 121.763992 0.0002929172 3.741005e-01 0.5185222158 17 50380312 50380501 190 + 2.078 2.102 0.083
ENSG00000154920 E022 230.783988 0.0011748010 1.300690e-04 0.0006591373 17 50380763 50381483 721 + 2.315 2.409 0.312