ENSG00000154845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400555 ENSG00000154845 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R1 protein_coding protein_coding 14.03603 8.98722 20.20031 1.111168 0.5736937 1.167541 5.340819 5.098334 6.632118 0.9642400 0.6609626 0.3787906 0.4054792 0.5580333 0.3275333 -0.2305000 0.007837545 0.0006423848 FALSE TRUE
ENST00000400556 ENSG00000154845 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R1 protein_coding protein_coding 14.03603 8.98722 20.20031 1.111168 0.5736937 1.167541 4.820003 2.483181 7.932271 0.3141244 0.1010528 1.6715641 0.3284958 0.2818000 0.3935667 0.1117667 0.146020467 0.0006423848 FALSE TRUE
MSTRG.15493.3 ENSG00000154845 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP4R1 protein_coding   14.03603 8.98722 20.20031 1.111168 0.5736937 1.167541 2.128383 1.047829 2.673897 0.0605039 0.1643651 1.3432226 0.1495833 0.1190667 0.1329667 0.0139000 0.768000468 0.0006423848 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154845 E001 0.1472490 0.0433479049 1.000000e+00   18 9546791 9546793 3 - 0.089 0.000 -9.201
ENSG00000154845 E002 21.5234760 0.0009160468 8.608734e-13 2.137202e-11 18 9546794 9546909 116 - 1.058 1.609 1.926
ENSG00000154845 E003 431.7057844 0.0041594814 2.280290e-18 1.201653e-16 18 9546910 9547712 803 - 2.490 2.786 0.984
ENSG00000154845 E004 118.5957216 0.0003479254 4.340368e-03 1.409612e-02 18 9547713 9547803 91 - 2.024 2.139 0.383
ENSG00000154845 E005 122.9619213 0.0014088387 9.068076e-03 2.644947e-02 18 9547804 9547952 149 - 2.040 2.155 0.386
ENSG00000154845 E006 59.9640120 0.0086802957 3.248934e-01 4.683071e-01 18 9549197 9549237 41 - 1.743 1.830 0.292
ENSG00000154845 E007 87.1343703 0.0004668686 9.102696e-03 2.654065e-02 18 9549238 9549338 101 - 1.889 2.009 0.405
ENSG00000154845 E008 0.5954526 0.0184156706 1.498552e-01 2.614891e-01 18 9549834 9550051 218 - 0.280 0.000 -12.452
ENSG00000154845 E009 112.2619660 0.0002954565 4.107625e-03 1.344467e-02 18 9550052 9550186 135 - 2.000 2.116 0.391
ENSG00000154845 E010 1.1532381 0.0290792131 6.199261e-01 7.372127e-01 18 9550187 9550277 91 - 0.281 0.381 0.627
ENSG00000154845 E011 60.1788266 0.0004286291 1.539322e-01 2.670219e-01 18 9550278 9550315 38 - 1.746 1.831 0.287
ENSG00000154845 E012 70.4935231 0.0003903761 4.112084e-02 9.310983e-02 18 9550316 9550368 53 - 1.803 1.910 0.358
ENSG00000154845 E013 46.8679209 0.0005026851 1.058383e-01 1.993573e-01 18 9550369 9550398 30 - 1.631 1.734 0.350
ENSG00000154845 E014 4.0609429 0.0239430438 6.527851e-01 7.634449e-01 18 9550399 9551939 1541 - 0.666 0.752 0.358
ENSG00000154845 E015 76.0384127 0.0003856617 1.830728e-03 6.697542e-03 18 9553322 9553422 101 - 1.817 1.964 0.493
ENSG00000154845 E016 0.0000000       18 9556981 9557220 240 -      
ENSG00000154845 E017 86.4415521 0.0003176001 1.122874e-01 2.088857e-01 18 9557221 9557325 105 - 1.900 1.981 0.271
ENSG00000154845 E018 87.5980308 0.0003191307 6.829116e-01 7.862386e-01 18 9557326 9557382 57 - 1.924 1.959 0.118
ENSG00000154845 E019 118.0541856 0.0002632898 3.400793e-01 4.840314e-01 18 9559419 9559541 123 - 2.046 2.097 0.171
ENSG00000154845 E020 88.5398549 0.0002871009 7.527098e-01 8.388289e-01 18 9559542 9559604 63 - 1.930 1.962 0.105
ENSG00000154845 E021 53.3293263 0.0004052355 8.273995e-01 8.914762e-01 18 9561980 9561982 3 - 1.722 1.730 0.028
ENSG00000154845 E022 99.1641235 0.0002651518 4.357806e-01 5.779572e-01 18 9561983 9562075 93 - 1.972 2.020 0.159
ENSG00000154845 E023 5.9149228 0.0027213927 2.355954e-01 3.690861e-01 18 9562922 9562922 1 - 0.761 0.928 0.649
ENSG00000154845 E024 13.1384643 0.0013600549 6.427387e-01 7.554580e-01 18 9562923 9563010 88 - 1.115 1.176 0.220
ENSG00000154845 E025 8.1241012 0.0020604090 3.004727e-01 4.421632e-01 18 9563011 9563046 36 - 0.983 0.877 -0.399
ENSG00000154845 E026 0.4439371 0.0215569426 2.587350e-01 3.960410e-01 18 9563047 9563146 100 - 0.225 0.000 -12.043
ENSG00000154845 E027 113.4240863 0.0003067662 8.354986e-01 8.971264e-01 18 9563378 9563550 173 - 2.044 2.057 0.041
ENSG00000154845 E028 0.0000000       18 9563551 9563866 316 -      
ENSG00000154845 E029 220.0195774 0.0026190463 2.554369e-02 6.300412e-02 18 9570157 9570683 527 - 2.354 2.291 -0.211
ENSG00000154845 E030 88.0931885 0.0119648280 2.283995e-02 5.741043e-02 18 9577064 9577191 128 - 1.984 1.841 -0.481
ENSG00000154845 E031 92.6918076 0.0180548606 6.043820e-02 1.273619e-01 18 9583117 9583275 159 - 2.001 1.873 -0.430
ENSG00000154845 E032 58.9032943 0.0004338287 1.731383e-03 6.381800e-03 18 9584515 9584580 66 - 1.810 1.674 -0.459
ENSG00000154845 E033 51.9382012 0.0004560482 1.627733e-04 8.038502e-04 18 9584721 9584775 55 - 1.770 1.589 -0.613
ENSG00000154845 E034 51.8915583 0.0037052126 6.380137e-03 1.961058e-02 18 9584776 9584828 53 - 1.760 1.614 -0.495
ENSG00000154845 E035 0.0000000       18 9588079 9588084 6 -      
ENSG00000154845 E036 0.1451727 0.0436112468 1.000000e+00   18 9588085 9588088 4 - 0.089 0.000 -10.480
ENSG00000154845 E037 38.6643803 0.0075041173 2.990409e-02 7.177186e-02 18 9588089 9588090 2 - 1.633 1.489 -0.494
ENSG00000154845 E038 42.3748909 0.0040061304 6.159773e-03 1.903205e-02 18 9588091 9588108 18 - 1.677 1.515 -0.553
ENSG00000154845 E039 36.5287785 0.0006743145 5.217586e-04 2.241143e-03 18 9588109 9588113 5 - 1.626 1.426 -0.685
ENSG00000154845 E040 46.9426340 0.0005084606 1.767939e-04 8.645001e-04 18 9588114 9588137 24 - 1.729 1.539 -0.647
ENSG00000154845 E041 41.8111159 0.0005364512 1.789201e-03 6.565025e-03 18 9588138 9588151 14 - 1.673 1.509 -0.558
ENSG00000154845 E042 43.3753015 0.0014322994 2.714009e-05 1.631428e-04 18 9588152 9588171 20 - 1.707 1.469 -0.810
ENSG00000154845 E043 43.8019604 0.0009310234 1.625283e-02 4.328095e-02 18 9588172 9588208 37 - 1.677 1.557 -0.409
ENSG00000154845 E044 41.0652568 0.0005567200 3.162724e-04 1.445739e-03 18 9588209 9588235 27 - 1.673 1.476 -0.670
ENSG00000154845 E045 41.3858958 0.0005208427 2.938032e-05 1.751972e-04 18 9588711 9588728 18 - 1.687 1.455 -0.790
ENSG00000154845 E046 67.4896176 0.0004051560 3.731426e-07 3.385374e-06 18 9588729 9588826 98 - 1.892 1.670 -0.749
ENSG00000154845 E047 50.6885554 0.0031532565 3.016161e-05 1.793930e-04 18 9588827 9588853 27 - 1.771 1.533 -0.809
ENSG00000154845 E048 71.4272485 0.0005884982 1.827784e-07 1.764784e-06 18 9593768 9593874 107 - 1.916 1.691 -0.760
ENSG00000154845 E049 1.2147514 0.0106196684 1.753446e-01 2.951182e-01 18 9594179 9594234 56 - 0.413 0.166 -1.765
ENSG00000154845 E050 1.2481495 0.0117909789 1.770739e-01 2.974342e-01 18 9594703 9594824 122 - 0.413 0.167 -1.764
ENSG00000154845 E051 2.0723229 0.0109652285 1.554171e-03 5.811026e-03 18 9594825 9595017 193 - 0.621 0.000 -14.228
ENSG00000154845 E052 60.0670976 0.0098176064 2.683513e-05 1.614992e-04 18 9595018 9595102 85 - 1.856 1.568 -0.977
ENSG00000154845 E053 20.4092015 0.0009427147 1.183008e-05 7.729360e-05 18 9595103 9595153 51 - 1.418 1.052 -1.293
ENSG00000154845 E054 0.0000000       18 9599633 9599741 109 -      
ENSG00000154845 E055 0.7469680 0.0178257460 9.018819e-02 1.754089e-01 18 9612457 9612690 234 - 0.329 0.000 -12.771
ENSG00000154845 E056 0.1472490 0.0433479049 1.000000e+00   18 9613527 9613589 63 - 0.089 0.000 -10.480
ENSG00000154845 E057 0.5106578 0.2523158259 3.075888e-01 4.498084e-01 18 9613796 9614225 430 - 0.089 0.288 2.050
ENSG00000154845 E058 36.3363547 0.0319623766 5.112409e-03 1.623635e-02 18 9614226 9614270 45 - 1.644 1.346 -1.023
ENSG00000154845 E059 1.0759214 0.0120660505 2.515224e-01 3.877733e-01 18 9614271 9614295 25 - 0.373 0.166 -1.543
ENSG00000154845 E060 26.2394810 0.0140769049 2.791962e-03 9.649345e-03 18 9614478 9614626 149 - 1.503 1.228 -0.954
ENSG00000154845 E061 2.1306245 0.0299652710 1.202190e-01 2.203135e-01 18 9614796 9615018 223 - 0.571 0.287 -1.542
ENSG00000154845 E062 1.3318114 0.0096070495 1.346227e-02 3.699321e-02 18 9615019 9615183 165 - 0.483 0.000 -13.602
ENSG00000154845 E063 0.1451727 0.0436112468 1.000000e+00   18 9615184 9615240 57 - 0.089 0.000 -10.480